Polyhydroxylated sterols from Monascus purpureus- fermented rice
Publication date: Available online 21 November 2019Source: SteroidsAuthor(s): Jin-Jie Li, Xiang-Jian Zhong, Xin Wang, Xi-Miao Yang, Jian-Yu Yue, Xuan Zhang, Jia-Chen Liu, Kai-Qi Wang, Xiao-Ya ShangAbstractUsing a cell-based cytotoxicity assay, two new polyhydroxylated sterols, 16(S),22(S)-epoxy-3β,5α,6β,20(R),23(R),25-hexahydroxy-7-ergostene and 3β,7β,8α,25-tetrahydroxy-5,22E-ergostadiene were isolated from the ethyl acetate portion of the ethanolic extract of Monascus purpureus. Their structures were elucidated by spectroscopic analysis and in comparison with those reported in the literature. Both compounds showed c...
Source: Steroids - November 21, 2019 Category: Drugs & Pharmacology Source Type: research
Microbial transformation of oral contraceptive ethisterone by Aspergillus niger and Cunninghamella blakesleeana
Publication date: February 2020Source: Steroids, Volume 154Author(s): Ambreen Aziz, Saira Bano, Atia-tul-Wahab, M. Iqbal ChoudharyAbstractEthisterone (17α-ethynyl-17β-hydroxyandrost-4-en-3-one) (1) is a synthetic steroidal estrogen. It is extensively used as an oral contraceptive. The current study involves the structural transformation of ethisterone (1) by Aspergillus niger, and Cunninghamella blakesleeana. Fermentation of 1 with C. blakesleeana afforded two new polar metabolites, 17α-ethynyl-6β,15β,17β-trihydroxyandrost-4-en-3-one, and 17α-ethynyl-7β,15β,17β-trihydroxyandrost-4-en-3-one, while transformation o...
Source: Steroids - November 20, 2019 Category: Drugs & Pharmacology Source Type: research
In memoriam: Virendra Bhushan Mahesh, Ph.D., D.Phil. April 25, 1932 – July 16, 2019
Publication date: Available online 13 November 2019Source: SteroidsAuthor(s): J. Charles Eldridge, Darrell W. Brann, Rajagopala Sridaran (Source: Steroids)
Source: Steroids - November 14, 2019 Category: Drugs & Pharmacology Source Type: research
Synthesis and biological evaluation of calcioic acid
Publication date: Available online 6 November 2019Source: SteroidsAuthor(s): Olivia B. Yu, Tania R. Mutchie, Elliot S. Di Milo, Leggy A. ArnoldAbstractHerein, we describe the synthesis of calcioic acid following a recently developed synthetic strategy for calcitroic acid. Several improvements to reaction conditions were made, which resulted in higher yields. The improved workup and isolation procedures are described. Furthermore, we investigated the interaction between the vitamin D receptor (VDR) and calcioic acid. Calcioic acid was able to bind VDR with a binding constant of 71 µM. In cells, calcioic acid reduced the tr...
Source: Steroids - November 7, 2019 Category: Drugs & Pharmacology Source Type: research
Ectopic pituitary adenoma of the TSH-secreting sphenoidal sinus with excellent response to somatostatin analogs. Theory of the embryogenesis and literature review from a clinical case
We report the case of a 52-year-old woman who was referred for primary hypothyroidism, who showed clinical signs of hyperthyroidism and had been under treatment with levothyroxine. Her exams revealed high levels of thyroid stimulating hormone (TSH), at odds with free thyroxin (FT4) and raised triiodothyronine (T3), which remained elevated after medication suspension, suggesting possible central hyperthyroidism. Sellar MRI showed normal pituitary gland, with a mass in the sphenoid sinus of 24 mm. A possible ectopic TSH secreting pituitary tumor of sphenoid sinus was hypothesized. After a single dose of a sustained-release p...
Source: Steroids - November 7, 2019 Category: Drugs & Pharmacology Source Type: research
Synthesis of Novel Hybrid Hetero-Steroids: Molecular docking Study Augmented Anti-Proliferative Properties Against Cancerous cells
In this study, a novel class of hetero-steroids were synthesized, analytical and spectral data proved the validity of the novel synthesized steroid derivatives. The cytotoxicity of the synthesized compounds 2, 5, 6, 7, 10, 11, 12, 14, 15, 17 were evaluated using human hepatocellular carcinoma cell lines (HepG2 and Huh-7) and non-small cell lung cancer (A549) cell lines. The synthesized compounds reported a remarkable gradual decrease in the cell viability of the three tested cancer cell lines. It was observed that compounds 2 and 12 had the lowest IC50s and the highest cytotoxic effects against all tested cell lines. As at...
Source: Steroids - October 31, 2019 Category: Drugs & Pharmacology Source Type: research
LncRNA-MALAT1 promotes osteogenic differentiation through regulating ATF4 by sponging miR-214 : implication of steroid-induced avascular necrosis of the femoral head
ConclusionMALAT1 was down-regulated, while miR-214 was elevated in SANFH tissues. MALAT1 promoted osteogenesis differentiation by sponging miR-214 to upregulate ATF4. (Source: Steroids)
Source: Steroids - October 31, 2019 Category: Drugs & Pharmacology Source Type: research
Estimation of the inhibiting impact of abiraterone D4A metabolite on human steroid 21-monooxygenase (CYP21A2)
Publication date: Available online 31 October 2019Source: SteroidsAuthor(s): Rami Masamrekh, Tatiana Filippova, Yaraslau Haurychenka, Kirill Shcherbakov, Alexander Veselovsky, Natallia Strushkevich, Tatsiana Shkel, Andrei Gilep, Sergey Usanov, Victoria Shumyantseva, Alexey KuzikovAbstractAbiraterone D4A metabolite, the product of 3β-hydroxysteroid dehydrogenase activity toward abiraterone, may serve as a potential antitumor agent for the treatment of prostate cancer. The main adverse effect of abiraterone is the disruption of corticosteroid biosynthesis, and the more pharmacologically active abiraterone D4A metabolite may...
Source: Steroids - October 31, 2019 Category: Drugs & Pharmacology Source Type: research
New Steroidal Oxazolines, Benzoxazoles and Benzimidazoles Related to Abiraterone and Galeterone
Publication date: Available online 31 October 2019Source: SteroidsAuthor(s): Alexandra S. Latysheva, Vladimir A. Zolottsev, Alexander V. Veselovsky, Kirill A. Scherbakov, Galina E. Morozevich, Vadim S. Pokrovsky, Roman A. Novikov, Vladimir P. Timofeev, Yaroslav V. Tkachev, Alexander Y. MisharinAbstractSeven new oxazoline, benzoxazole and benzimidazole derivatives were synthesized from 3β-acetoxyandrosta-5,16-dien-17-carboxylic, 3β-acetoxyandrost-5-en-17β-carboxylic and 3β-acetoxypregn-5-en-21-oic acids. Docking to active site of human 17α-hydroxylase/17,20-lyase revealed that all oxazolines, as well as benzoxazoles an...
Source: Steroids - October 31, 2019 Category: Drugs & Pharmacology Source Type: research
Antimicrobial properties of amine- and guanidine-functionalized derivatives of betulinic, ursolic and oleanolic acids: Synthesis and structure/activity evaluation
Publication date: Available online 31 October 2019Source: SteroidsAuthor(s): Anna Yu. Spivak, Rezeda R. Khalitova, Darya A. Nedopekina, Rinat R. GubaidullinAbstractA series of 34 new amine- and guanidine-functionalized derivatives of betulinic, ursolic, and oleanolic acids were synthesized and tested for their antimicrobial activity against the growth of four bacterial strains (Escherichia coli, Acinetobacter baumannii, Pseudomonas aeruginosa, and Staphylococcus aureus (MRSA)) and two fungal strains (Candida albicans and Cryptococcus neoforman). The obtained compounds were also tested for the cytotoxic effect against HEK29...
Source: Steroids - October 31, 2019 Category: Drugs & Pharmacology Source Type: research
Serum 25(OH)D concentration and its association with inflammation and oxidative stress in the middle-aged Indian healthy and diabetic subjects
ConclusionThis study suggest that vitamin D may have significant implications in the prevention of inflammation and oxidative stress. (Source: Steroids)
Source: Steroids - October 30, 2019 Category: Drugs & Pharmacology Source Type: research
Sarsasapogenin: A steroidal saponin from Asparagus racemosus as multi target directed ligand in Alzheimer’s Disease
Publication date: Available online 28 October 2019Source: SteroidsAuthor(s): Priya Kashyap, Kalaivani Muthusamy, Manisha Niranjan, Shweta Trikha, Suresh KumarAbstractAlzheimer’s Disease (AD) is multi-factorial disorder characterized by impaired memory and cognition deficit. AD is characterized by impaired cholinergic transmission, extracellular amyloid beta deposits , neurofibillary tangles and oxidative stress. A multi-target directed ligand (MTDL) approach is required to devise a therapeutic strategy against AD. In the present study, Asparagus racemosus aqueous extract was chosen, as it possess abundant medicinal prope...
Source: Steroids - October 30, 2019 Category: Drugs & Pharmacology Source Type: research
Steroid Analysis by Ion Mobility Spectrometry
Publication date: Available online 28 October 2019Source: SteroidsAuthor(s): Alana L. Rister, Eric D. DoddsAbstractSteroids are an important biomolecule class for analysis due to their promise as biomarkers for various diseases and their abuse as performance enhancers in sports. Current analytical methods, including chromatography and nuclear magnetic resonance spectroscopy, fall short of being able to confidently analyze steroids, partly due to the large number of steroid isomers. Ion mobility spectrometry (IMS), a gas-phase ion separator, has shown potential for steroid analysis both in conjunction with liquid chromatogr...
Source: Steroids - October 30, 2019 Category: Drugs & Pharmacology Source Type: research
The impact of nandrolone decanoate abuse on experimental animal model: Hormonal and biochemical assessment
Publication date: Available online 24 October 2019Source: SteroidsAuthor(s): Neveen A. Salem, Hanan S. AlnahdiAbstractNandrolone decanoate (ND) is one of the most commonly abused anabolic androgenic steroids compounds in the world owing to its ability to improve physical performance but its abuse is associated with several adverse effects. The current study was performed to evaluate the effect of recommended and overdose of nandrolone decanoate (ND) for short and long term on the alterations of biochemical markers related to kidney, liver, adrenal, thyroid gland functions and oxidant and antioxidant activities. Sixty male ...
Source: Steroids - October 25, 2019 Category: Drugs & Pharmacology Source Type: research
Synthesis of cytotoxic urs-12-ene- and 28-norurs-12-ene- type conjugates with amino- and mercapto-1,3,4-oxadiazoles and mercapto-1,2,4-triazoles
Publication date: January 2020Source: Steroids, Volume 153Author(s): Sergey A. Popov, Marya D. Semenova, Dmitry S. Baev, Tatiana S. Frolova, Elvira E. Shults, Chengzhang Wang, Māris TurksAbstractA small library of 2-mercapto-1,3,4-oxadiazoles, 2-amino-1,3,4-oxadiazoles, and 3-mercapto-1,2,4-triazoles attached to the urs-12-ene- and 28-nor-urs-12-ene skeleton has been obtained. Ursolic acid derived hydrazides have been identified as useful starting materials for the developed synthesis. Ursolic acid hydrazide provided access to oxadiazoles attached directly to C-17 of the ursane core, but synthesis of structurally related ...
Source: Steroids - October 24, 2019 Category: Drugs & Pharmacology Source Type: research
