Sinulasterols A–C, three new bioactive oxygenated steroids from the South China Sea soft coral Sinularia depressa

Publication date: May 2020Source: Steroids, Volume 157Author(s): Min Yang, Wan-Xiang Cui, Heng Li, Song-Wei Li, Li-Gong Yao, Wei Tang, I. Wayan Mudianta, Yue-Wei GuoAbstractThree new oxygenated steroids, sinulasterols A–C (1–3), along with seven known related steroids 4–10, were isolated from the Chinese soft coral Sinularia depressa. The structures of the new compounds were established from extensive spectroscopic data analyses and by comparison of their spectral data with those reported in the literature. Among the new compounds, metabolites 1 and 2 featured on unusual C-18 oxygenated pattern. In the TNF-α bioassay, compound 4 exhibited a potent inhibitory activity (IC50 = 12.1 μM), which was analogous to the positive control dexamethasone (IC50 = 8.7 μM), metabolites 1 and 2 displayed a moderate inhibitory activity (IC50 51.1 μM and 22.7 μM respectively).Graphical abstract
Source: Steroids - Category: Drugs & Pharmacology Source Type: research