Systemic cytokine response to three bouts of eccentric exercise
Publication date: 2014 Source:Results in Immunology, Volume 4 Author(s): Stephen M. Cornish , Steven T. Johnson This research examined the changes in inflammatory cytokines interleukin 6 (IL-6), IL-1β, IL-10, as well as muscle force, muscle soreness, thigh circumference, and range of motion in response to 3 bouts of eccentric knee extension. Ten males were recruited to participate. The participants performed eccentric exercise on 3 consecutive days on the knee extensors on the right leg separated by 24 h. Participants performed 6 sets of 10 repetitions of isokinetic eccentric knee extension at 120° per second....
Source: Results in Immunology - November 6, 2014 Category: Allergy & Immunology Source Type: research
Evidence for simvastatin anti-inflammatory actions based on quantitative analyses of NETosis and other inflammation/oxidation markers
Publication date: 2014 Source:Results in Immunology, Volume 4 Author(s): Walid M. Al-Ghoul , Margarita S. Kim , Nadeem Fazal , Anser C. Azim , Ashraf Ali Simvastatin (SMV) has been shown to exhibit promising anti-inflammatory properties alongside its classic cholesterol lowering action. We tested these emerging effects in a major thermal injury mouse model (3rd degree scald, ∼20% TBSA) with previously documented, inflammation-mediated intestinal defects. Neutrophil extracellular traps (NETs) inflammation measurement methods were used alongside classic gut mucosa inflammation and leakiness measurements with exoge...
Source: Results in Immunology - November 6, 2014 Category: Allergy & Immunology Source Type: research
IL-6 signalling in patients with acute ST-elevation myocardial infarction
In conclusion, circulating levels of IL-6 and CRP, but not the soluble forms of the receptor (sIL-6R) or the receptor signalling subunit (sgp130) were associated with the extent of myocardial necrosis. The biological importance of the IL-6/gp130-mediated signalling pathways in patients with acute myocardial infarction and dysglycemia should be further elucidated. (Source: Results in Immunology)
Source: Results in Immunology - November 6, 2014 Category: Allergy & Immunology Source Type: research
Characterization of the liver-macrophages isolated from a mixed primary culture of neonatal swine hepatocytes
In this study, we aim to apply this method to the neonatal swine liver. Swine parenchymal hepatocytes were isolated by a two-step collagenase perfusion method and cultured in T75 culture flasks. Similar to the rat and bovine cells, the swine hepatocytes retained an epithelial cell morphology for only a few days and progressively changed into fibroblastic cells. After 5–13 days of culture, macrophage-like cells actively proliferated on the mixed fibroblastic cell sheet. Gentle shaking of the culture flask followed by the transfer and brief incubation of the culture supernatant resulted in a quick and selective adhesion o...
Source: Results in Immunology - November 6, 2014 Category: Allergy & Immunology Source Type: research
