Bacteriophage research – What we have learnt and what still needs to be addressed
This article touches on the first 100 years of phage research with the author commenting on what he thinks are the highlights, and what needs to be addressed. (Source: Research in Microbiology)
Source: Research in Microbiology - May 26, 2018 Category: Microbiology Source Type: research
molecular mechanisms of AcrB-mediated multidrug export
Publication date: Available online 25 May 2018 Source:Research in Microbiology Author(s): martijn zwama, akihito yamaguchi The over-expression of multidrug efflux pumps belonging to the Resistance-Nodulation-Division (RND) superfamily is one of the main causes of multidrug-resistance (MDR) in Gram-negative pathogenic bacteria. AcrB is the most thoroughly studied RND transporter and has functioned as a model for our understanding of efflux-mediated MDR. This multidrug-exporter can recognize and transport a wide range of structurally unrelated compounds (including antibiotics, dyes, bile salts and detergents), while it s...
Source: Research in Microbiology - May 25, 2018 Category: Microbiology Source Type: research
Evaluating the use of diversity indices to distinguish between microbial communities with different traits
Publication date: Available online 23 May 2018 Source:Research in Microbiology Author(s): Sergey Feranchuk, Natalia Belkova, Ulyana Potapova, Dmitry Kuzmin, Sergei Belikov Several measures of biodiversity are commonly used to describe microbial communities, analyzed using 16S gene sequencing. A wide range of available experiments on 16S gene sequencing allows us to present a framework for a comparison of various diversity indices. The criterion for the comparison is the statistical significance of the difference in index values for microbial communities with different traits, within the same experiment. The results ...
Source: Research in Microbiology - May 23, 2018 Category: Microbiology Source Type: research
Prevalence and dynamics of Lactobacillus sp. in the lower respiratory tract of patients with cystic fibrosis
Publication date: Available online 23 May 2018 Source:Research in Microbiology Author(s): Marie-Sarah Fangous, Ismaïl Lazzouni, Youenn Alexandre, Stéphanie Gouriou, Sylvie Boisramé, Sophie Vallet, Jean Le Bihan, Sophie Ramel, Geneviève Héry-Arnaud, Rozenn Le Berre No prevalence or dynamics analysis of Lactobacilli in the lung of cystic fibrosis (CF) patients has yet been conducted. In order to use them as probiotics in the treatment of Pseudomonas aeruginosa infection, we describe their lung epidemiology. Over a period of 8 months, we analyzed 279 sputum samples from 124 CF patients classified according to...
Source: Research in Microbiology - May 23, 2018 Category: Microbiology Source Type: research
New cblA gene participates in regulation of cobalt-dependent transcription of nitrile hydratase genes in Rhodococcus rhodochrous
Publication date: Available online 23 May 2018 Source:Research in Microbiology Author(s): Konstantin V. Lavrov, Anna O. Shemyakina, Elena G. Grechishnikova, Andrey D. Novikov, Denis D. Derbikov, Tatyana I. Kalinina, Alexander S. Yanenko Rhodococcus strains are important biocatalysts used for biotechnological production of acrylamide catalysed by a nitrile hydratase (NHase) containing cobalt. This metalloenzyme is present at high intracellular concentrations representing up to 50% of the soluble proteins in Rhodococcus rhodochrous M8 strain. Cobalt ions were formerly reported to be essential for the synthesis of th...
Source: Research in Microbiology - May 23, 2018 Category: Microbiology Source Type: research
