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Hair analysis to monitor adherence to prescribed chronic inhaler drug therapy in patients with asthma or COPD
ConclusionsThis is the first study to demonstrate that inhaled medication can be measured in hair samples from subjects with asthma and/or COPD. The results show that hair drug concentration data could potentially provide a record of historical adherence to inhaled therapeutics. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - July 5, 2018 Category: Respiratory Medicine Source Type: research

Is aging a "comorbidity" of asthma?
This article will discuss the multitude of factors that justify considering aging as a comorbidity of asthma. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - July 5, 2018 Category: Respiratory Medicine Source Type: research

Oropharyngeal administration of silica in Swiss mice: A robust and reproducible model of occupational pulmonary fibrosis
Publication date: August 2018Source: Pulmonary Pharmacology & Therapeutics, Volume 51Author(s): Sachin Karkale, Amit Khurana, Mohd Aslam Saifi, Chandraiah Godugu, Venu TallaAbstractPulmonary fibrosis (PF) is a lethal end stage of interstitial lung disease with increasing prevalence. The disease burden of PF has seen a sharp surge in the past two decades owing to entry of heavy amount of particulate matter due to industrialization and urbanization. In this work, we developed an oropharyngeal aspiration model of silica (1.5 mg/mice) induced pulmonary fibrosis as a homogeneous, reproducible, simple and alternative strategy in...
Source: Pulmonary Pharmacology and Therapeutics - July 5, 2018 Category: Respiratory Medicine Source Type: research

Impact of doxofylline in COPD: A pairwise meta-analysis
Publication date: August 2018Source: Pulmonary Pharmacology & Therapeutics, Volume 51Author(s): Mario Cazzola, Luigino Calzetta, Paola Rogliani, Clive Page, Maria Gabriella MateraAbstractDoxofylline is an effective bronchodilator for relieving airway obstruction in patients with asthma or chronic obstructive pulmonary disease (COPD), and displays a better safety profile with respect to theophylline. Herein, we performed a pairwise meta-analysis of the currently available data to provide consistent and homogeneous findings on the impact of this xanthine in COPD patients. Results obtained from 820 patients were selected from...
Source: Pulmonary Pharmacology and Therapeutics - July 5, 2018 Category: Respiratory Medicine Source Type: research

In vivo and in vitro investigation of anti-inflammatory and mucus-regulatory activities of a fixed combination of thyme and primula extracts
Publication date: August 2018Source: Pulmonary Pharmacology & Therapeutics, Volume 51Author(s): Jan Seibel, Kirill Kryshen, Judit E. Pongrácz, Martin D. LehnerAbstractHypersecretion of viscous mucus is one of the hallmark symptoms of acute and chronic bronchitis and typically develops secondary to an inflammation of the airway epithelium. Bronchipret® TP film-coated tablets (BRO), a herbal medicinal product containing a fixed combination of thyme herb and primula root extracts, has been successfully used clinically for the treatment of acute bronchitis for more than two decades. However, the underlying pharmacological me...
Source: Pulmonary Pharmacology and Therapeutics - July 5, 2018 Category: Respiratory Medicine Source Type: research