Contents
(Source: Ophthalmology)
Source: Ophthalmology - April 19, 2018 Category: Opthalmology Source Type: research
Corrigendum
The authors of “XEN Implant-Related Endophthalmitis” (Ophthalmology. 2018;125(2):209) would like to issue a correction to their Pictures& Perspectives. The author Saurabh Goyal should have appeared as the second author. The authors should have appeared as follows: (Source: Ophthalmology)
Source: Ophthalmology - April 19, 2018 Category: Opthalmology Tags: Corrigendum Source Type: research
Corrigendum
The authors of “Ultrastructural integrity of human capsulotomies created by a thermal device” (Ophthalmology. 2018;125:340–344) would like to issue the following correction to the magnification (in boldface) in Fig 3A. The figure legend should have appeared as follows: “Figure 3. A, Irregularly rolled edg e of the precision pulse capsulotomy (PPC) at low magnification (original magnification, ×500). B, Subtle PPC margin irregularities at high magnification (arrow indicates the width of the capsulotomy margin; original magnification, ×4000). (Source: Ophthalmology)
Source: Ophthalmology - April 19, 2018 Category: Opthalmology Tags: Corrigendum Source Type: research
Corrigendum
The authors of “Foveal hypoplasia in patients with Stickler syndrome” (Ophthalmology. 2017;124:896–902) would like to issue the following correction to their article. The mutation description in the second paragraph of the Methods section is incorrect. The corrected description appears in boldface: “These 4 patients had known mutations: c.1693C>T (p.Arg565Cys) for patients 22 and 23, c.1957C>T (p.R653*) for patient 24, and c.3624delT (p.P1208fs) for patient 25. ” (Source: Ophthalmology)
Source: Ophthalmology - April 19, 2018 Category: Opthalmology Tags: Corrigendum Source Type: research
A Fragility Index: Handle with Care
Criticizing P values never goes out of style. A person looking for examples of misinterpretation and miscalculation will not search long.1 More damning, the P value answers a question the reader may not have even asked, unless of course they like to frame their questions conditioned on a null hypothesis. The fragility index points out yet another flaw in relying on a dichotomous threshold for significance. The index highlights how conclusions based on P values close to the threshold could be dependent on a few cases going the right way. (Source: Ophthalmology)
Source: Ophthalmology - April 19, 2018 Category: Opthalmology Authors: Travis C. Porco, Thomas M. Lietman Tags: Commentary Source Type: research
Abstracts
Justis P. Ehlers, MD, Mehnaz Khan, MD, Daniel Petkovsek, MD, Laura Stiegel, Peter K. Kaiser, MD, Rishi P. Singh, MD, Jamie L. Reese, BSN, Sunil K. Srivastava, MD (Source: Ophthalmology)
Source: Ophthalmology - April 19, 2018 Category: Opthalmology Source Type: research
This Issue at a Glance
Atchison et al (p. 676) set out to identify the sustained effects of anti-vascular endothelial growth factor (VEGF) drug injections on intraocular pressure (IOP). They analyzed 23 873 patients from the AAO IRIS Registry who received an intravitreous injection with aflibercept, bevacizumab, or ranibizumab in their right eyes between January 1, 2013 and December 31, 2015, and they used fellow, untreated eyes for comparison. Patients showed a statistically significant decrease in IOP, with a mean of 0.9 mmHg in treated eyes compared with an average decrease of 0.2 mmHg in fellow, untreated eyes. (Source: Ophthalmology)
Source: Ophthalmology - April 19, 2018 Category: Opthalmology Authors: Sandeep Ravindran Tags: This issue at a glance Source Type: research
A Simple Vista en Este N úmero
Atchison y otros (p. 676) se propusieron identificar los efectos sostenidos de las inyecciones de antifactor de crecimiento endotelial vascular (VEGF) en la presi ón intraocular (IOP). Analizaron 23.873 pacientes del Registro AAO IRIS que recibieron una inyección intravítrea de aflibercept, bevacizumab o ranibizumab en el ojo derecho entre el 1 de enero de 2013 y el 31 de diciembre de 2015, utilizando los ojos contralaterales no tratados como comparación. Los pacientes mostraron una reducción estadísticamente significativa de la IOP con una media de 0,9 mmHg en los ojos tratados comparada con una reducción promedio ...
Source: Ophthalmology - April 19, 2018 Category: Opthalmology Authors: Sandeep Ravindran Tags: This issue at a glance Source Type: research
期刊一览
Atchison (p. 676) 等就抗血管内皮生长因子 (anti-vascular endothelial growth factor [VEGF]) 药物注射对眼压 (intraocular pressure [IOP]) 的持续性影响进行研究。他们共分析了来自AAO IRIS登记的23873名右眼接受玻璃体腔注射患者, 于2013年1月1日至2015年12月31日期间分 别接受阿柏西普、贝伐单抗或雷珠单抗治疗; 并与未治疗的对侧眼进行比较。患者IOP显著降低, 具有统计学差异; 在治疗眼平均下降0.9 mmHg, 对侧未治疗眼平均下降0.2 mmHg。多数亚组中, 贝伐单抗治疗较阿柏西普和雷珠单抗治疗IOP下降 程度...
Source: Ophthalmology - April 19, 2018 Category: Opthalmology Authors: Sandeep Ravindran Tags: This issue at a glance Source Type: research
Phase 2 Randomized, Double-Masked, Vehicle-Controlled Trial of Recombinant Human Nerve Growth Factor for Neurotrophic Keratitis
To evaluate the safety and efficacy of topical recombinant human nerve growth factor (rhNGF) for treating moderate-to-severe neurotrophic keratitis (NK), a rare degenerative corneal disease resulting from impaired corneal innervation. (Source: Ophthalmology)
Source: Ophthalmology - April 10, 2018 Category: Opthalmology Authors: Stefano Bonini, Alessandro Lambiase, Paolo Rama, Francesco Sinigaglia, Marcello Allegretti, Wendy Chao, Flavio Mantelli, REPARO Study Group Source Type: research
A Deep Learning Algorithm for Prediction of Age-Related Eye Disease Study Severity Scale for Age-Related Macular Degeneration from Color Fundus Photography
Age-related macular degeneration (AMD) is a common threat to vision. While classification of disease stages is critical to understanding disease risk and progression, several systems based on color fundus photographs are known. Most of these require in-depth and time-consuming analysis of fundus images. Herein, we present an automated computer-based classification algorithm. (Source: Ophthalmology)
Source: Ophthalmology - April 10, 2018 Category: Opthalmology Authors: Felix Grassmann, Judith Mengelkamp, Caroline Brandl, Sebastian Harsch, Martina E. Zimmermann, Birgit Linkohr, Annette Peters, Iris M. Heid, Christoph Palm, Bernhard H.F. Weber Source Type: research
Phase I Trial of Recombinant Human Nerve Growth Factor for Neurotrophic Keratitis
Neurotrophic keratitis/keratopathy (NK), a rare degenerative corneal disease, lacks effective pharmacologic therapies.1 Because NK pathology involves trigeminal nerve damage and loss of corneal innervation, nerve growth factor (NGF) is surmised to promote healing of NK.2 Preliminary studies with murine NGF demonstrated efficacy for treating corneal neurotrophic ulcers;3 however, the complex tertiary structure of NGF has complicated the production of recombinant human NGF (rhNGF) suitable for clinical development. (Source: Ophthalmology)
Source: Ophthalmology - April 10, 2018 Category: Opthalmology Authors: Stefano Bonini, Alessandro Lambiase, Paolo Rama, Isabella Filatori, Marcello Allegretti, Wendy Chao, Flavio Mantelli, REPARO Study Group Tags: Reports Source Type: research
Chemodenervation for the Treatment of Facial Dystonia
To review the medical literature on the outcomes and complications of various Food and Drug Administration-approved botulinum toxins for benign essential blepharospasm (BEB) and hemifacial spasm (HFS). (Source: Ophthalmology)
Source: Ophthalmology - April 10, 2018 Category: Opthalmology Authors: Jurij R. Bilyk, Michael T. Yen, Elizabeth A. Bradley, Edward J. Wladis, Louise A. Mawn Tags: Ophthalmic Technology Assessment Source Type: research
Posterior Vitreous Detachment as Observed by Wide-Angle OCT Imaging
Posterior vitreous detachment (PVD) plays an important role in vitreoretinal interface disorders. Historically, observations of PVD using OCT have been limited to the macular region. The purpose of this study is to image the wide-angle vitreoretinal interface after PVD in normal subjects using montaged OCT images. (Source: Ophthalmology)
Source: Ophthalmology - April 6, 2018 Category: Opthalmology Authors: Mayuka Tsukahara, Keiko Mori, Peter L. Gehlbach, Keisuke Mori Source Type: research
Contact Lens Correction of Aphakia in Children
To review the published literature to assess the visual outcomes and adverse events associated with the 2 most commonly used contact lenses for treating aphakia in children: silicone elastomer (SE) and rigid gas permeable (RGP). (Source: Ophthalmology)
Source: Ophthalmology - April 6, 2018 Category: Opthalmology Authors: Scott R. Lambert, Raymond T. Kraker, Stacy L. Pineles, Amy K. Hutchinson, Lorri B. Wilson, Jennifer A. Galvin, Deborah K. VanderVeen Tags: Ophthalmic Technology Assessment Source Type: research
