Evaluation of Primary Angle-Closure Glaucoma Susceptibility Loci in Patients with Early Stages of Angle-Closure Disease
To investigate whether newly identified genetic loci for primary angle-closure glaucoma (PACG) are associated with early stage angle-closure disease defined as primary angle closure suspect (PACS). (Source: Ophthalmology)
Source: Ophthalmology - January 6, 2018 Category: Opthalmology Authors: Monisha E. Nongpiur, Ching-Yu Cheng, Roopam Duvesh, Saravanan Vijayan, Mani Baskaran, Chiea-Chuen Khor, John Allen, Srinivasan Kavitha, Rengaraj Venkatesh, David Goh, Rahat Husain, Pui Yi Boey, Desmond Quek, Ching Lin Ho, Tina T. Wong, Shamira Perera, Tie Source Type: research
Guidance on Noncorticosteroid Systemic Immunomodulatory Therapy in Noninfectious Uveitis
An international, expert-led consensus initiative to develop systematic, evidence-based recommendations for the treatment of noninfectious uveitis in the era of biologics. (Source: Ophthalmology)
Source: Ophthalmology - January 6, 2018 Category: Opthalmology Authors: Andrew D. Dick, James T. Rosenbaum, Hassan A. Al-Dhibi, Rubens Belfort, Antoine P. Br ézin, Soon Phaik Chee, Janet L. Davis, Athimalaipet V. Ramanan, Koh-Hei Sonoda, Ester Carreño, Heloisa Nascimento, Sawsen Salah, Sherveen Salek, Jay Siak, Laura Steepl Source Type: research
Glaucomatous Optic Neuropathy Associated with Nocturnal Dip in Blood Pressure
To determine which nocturnal blood pressure (BP) parameters (low levels or extreme dipper status) are associated with an increased risk of glaucomatous damage in Hispanics. (Source: Ophthalmology)
Source: Ophthalmology - January 6, 2018 Category: Opthalmology Authors: Jes ús D. Melgarejo, Joseph H. Lee, Michele Petitto, Juan B. Yépez, Felipe A. Murati, Zhezhen Jin, Carlos A. Chávez, Rosa V. Pirela, Gustavo E. Calmón, Winston Lee, Matthew P. Johnson, Luis J. Mena, Lama A. Al-Aswad, Joseph D. Terwilliger, Rando Allik Source Type: research
Early Patterns of Macular Degeneration in ABCA4-Associated Retinopathy
To describe the earliest features of ABCA4-associated retinopathy. (Source: Ophthalmology)
Source: Ophthalmology - January 6, 2018 Category: Opthalmology Authors: Kamron N. Khan, Melissa Kasilian, Omar A.R. Mahroo, Preena Tanna, Angelos Kalitzeos, Anthony G. Robson, Kazushige Tsunoda, Takeshi Iwata, Anthony T. Moore, Kaoru Fujinami, Michel Michaelides Tags: Original Article Source Type: research
Nationwide Prevalence of Self-Reported Serious Sensory Impairments and Their Associations with Self-Reported Cognitive and Functional Difficulties
To estimate the nationwide prevalence of self-reported serious vision impairment (SVI), serious hearing impairment (SHI), and serious dual sensory impairment (DSI; i.e., concomitant SVI and SHI) and to characterize their associations with self-reported cognitive, independent living, self-care, and ambulatory difficulties. (Source: Ophthalmology)
Source: Ophthalmology - January 4, 2018 Category: Opthalmology Authors: Spencer D. Fuller, Lucy I. Mudie, Carlos Siordia, Bonnielin K. Swenor, David S. Friedman Tags: Original Article Source Type: research
Nonsyndromic Retinitis Pigmentosa in the Ashkenazi Jewish Population
To analyze the genetic and clinical findings in retinitis pigmentosa (RP) patients of Ashkenazi Jewish (AJ) descent, aiming to identify genotype –phenotype correlations. (Source: Ophthalmology)
Source: Ophthalmology - December 22, 2017 Category: Opthalmology Authors: Adva Kimchi, Samer Khateb, Rong Wen, Ziqiang Guan, Alexey Obolensky, Avigail Beryozkin, Shoshi Kurtzman, Anat Blumenfeld, Eran Pras, Samuel G. Jacobson, Tamar Ben-Yosef, Hadas Newman, Dror Sharon, Eyal Banin Source Type: research
Re: Singh et al.: Nepafenac 0.3% after cataract surgery in patients with diabetic retinopathy: results of 2 randomized phase 3 studies (Ophthalmology. 2017;124:776-785)
We read with interest the article by Singh et al1 that presented separate and pooled data from 2 large prospective (studies 1 and 2), randomized, parallel, phase III clinical trials demonstrating that nepafenac 0.3% once daily reduced the risk of macular edema (ME) after cataract surgery in patients with diabetic retinopathy (DR). The study h as several notable strengths including its large size (>600 eyes enrolled in each study), rigorous design, and use of an objective definition of ME (30% change from baseline). (Source: Ophthalmology)
Source: Ophthalmology - December 18, 2017 Category: Opthalmology Authors: Gowtham Jonna, Stephen J. Kim Tags: Correspondence Source Type: research
Re: Singh et al.: Nepafenac 0.3% after cataract surgery in patients with diabetic retinopathy: result of 2 randomized phase 3 studies (Ophthalmology. 2017;124:776-785)
We read the article published by Singh et al1 with great interest. However, we believe that some discussion is required. The authors present results of 2 studies assessing clinical benefits of nepafenac 0.3% over vehicle in reducing the risk of pseudophakic cystoid macular edema (PCME) in phacoemulsification cataract surgery. (Source: Ophthalmology)
Source: Ophthalmology - December 18, 2017 Category: Opthalmology Authors: Andrzej Grzybowski, Piotr Kanclerz Tags: Correspondence Source Type: research
Re: Singh et al.: Nepafenac 0.3% after cataract surgery in patients with diabetic retinopathy: results of 2 randomized phase 3 studies (Ophthalmology. 2017;124:776-785)
This report consisted of results from 2 substudies. Substudy 1 showed statistically significantly better visual outcomes in those on nepafenac; substudy 2 failed to reach many of the same results. This finding is similar to 2 parallel studies of nepafenac 0.1% in patients with diabetic retinopathy undergoing cataract surgery where both studies found anatomic benefit,2,3 but one did not show significant visual benefit. (Source: Ophthalmology)
Source: Ophthalmology - December 18, 2017 Category: Opthalmology Authors: Bobeck S. Modjtahedi, Donald S. Fong Tags: Correspondence Source Type: research
Reply
We appreciate the interest shown by Drs Jonna and Kim in our work. The main aim of our study was to evaluate the clinical benefit of prophylactic use of nepafenac 0.3% once daily in reducing the risk of postoperative macular edema (ME) after cataract surgery in patients with nonproliferative diabetic retinopathy. It is a known fact that even though the magnitude of postoperative ME is high, in most cases ME is self-limiting and not associated with impaired vision. However, it cannot be determined in which patients postoperative ME will lead to significant loss of visual acuity (VA). (Source: Ophthalmology)
Source: Ophthalmology - December 18, 2017 Category: Opthalmology Authors: Rishi P. Singh, Robert Lehmann, Joseph Martel, Kevin Jong, Ayala Pollack, Alexis Tsorbatzoglou, Giovanni Staurenghi, Guadalupe Cervantes-Coste Cervantes, Louis Alpern, Satish Modi, Liza Svoboda, Adeniyi Adewale, Glenn J. Jaffe Tags: Correspondence Source Type: research
Re: Maggio et al.: Vitreomacular adhesion and the risk of neovascular age-related macular degeneration (Ophthalmology. 2017;124:657-666)
We have read with interest the publication of Maggio et al, wherein they report no relationship between the state of the vitreomacular interface and the risk of neovascular age-related macular degeneration (AMD). This finding is in contrast with multiple previous studies, which found that the presence of a posterior vitreous detachment (PVD) was associ ated with dry AMD, whereas vitreomacular adhesion is a risk factor for exudative AMD.1–3 Studies have also found that vitreomacular adhesion hampers therapy with anti-vascular endothelial growth factor injections, necessitating more injections with poorer results. (Source: Ophthalmology)
Source: Ophthalmology - December 18, 2017 Category: Opthalmology Authors: J. Sebag, Susanne Binder Tags: Correspondence Source Type: research
Reply
We would like to thank Drs Sebag and Binder for their interest in our work and for the valuable observations regarding the challenge in assessing the vitreomacular interface status. (Source: Ophthalmology)
Source: Ophthalmology - December 18, 2017 Category: Opthalmology Authors: Emilia Maggio, Antonio Polito, Massimo Guerriero, Guido Prigione, Barbara Parolini, Grazia Pertile Tags: Correspondence Source Type: research
Reply
We appreciate the interest shown by Drs Modjtahedi and Fong in our study. However, we would like to clarify some points that they have raised regarding the nepafenac 0.3% studies and the outcomes. (Source: Ophthalmology)
Source: Ophthalmology - December 18, 2017 Category: Opthalmology Authors: Rishi P. Singh, Robert Lehmann, Joseph Martel, Kevin Jong, Ayala Pollack, Alexis Tsorbatzoglou, Giovanni Staurenghi, Guadalupe Cervantes-Coste Cervantes, Louis Alpern, Satish Modi, Liza Svoboda, Adeniyi Adewale, Glenn J. Jaffe Tags: Correspondence Source Type: research
Reply
We appreciate the interest shown by Drs Grzybowski and Kanclerz in our study. However, we would like to clarify and discuss some points they have raised in their letter. (Source: Ophthalmology)
Source: Ophthalmology - December 18, 2017 Category: Opthalmology Authors: Rishi P. Singh, Robert Lehmann, Joseph Martel, Kevin Jong, Ayala Pollack, Alexis Tsorbatzoglou, Giovanni Staurenghi, Guadalupe Cervantes-Coste Cervantes, Louis Alpern, Satish Modi, Liza Svoboda, Adeniyi Adewale, Glenn J. Jaffe Tags: Correspondence Source Type: research
Spontaneous Rupture of an Iris Stromal Cyst
A 48-year-old man was referred for evaluation of an iris lesion (Fig 1A) in his left eye. His ocular history included ocular trauma in his left eye at age 8 resulting only in a brow laceration. On presentation, he was asymptomatic with 20/20 visual acuity. Ultrasound biomicroscopy revealed a 3-mm width × 3.6-mm height iris stromal cyst (Fig 1B). Treatment options were discussed and he chose observation. It was stable at 3 months, but at the 6-month follow-up it had ruptured without trauma (Fig 1C) resulting in significant endothelial touch and decrease in size (3-mm width × 1.6-mm height) (F ig 1D). (Source: Ophthalmology)
Source: Ophthalmology - December 18, 2017 Category: Opthalmology Authors: Laura B. Hall, Kristen Nwanyanwu Tags: Pictures & Perspectives Source Type: research
