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Placement of self-expandable bifurcated metallic stents without use of fluoroscopic and guidewire guidance to palliate central airway lesions
Conclusion Endobronchial placement of covered self-expandable metallic stents was safe and readily performed in patients with airway obstructions. Neither fluoroscopic nor guidewire guidance was required. Neither patients nor staff were exposed to radiation, and costly guidewire guidance was not necessary. The procedure is cost-effective. (Source: Multidisciplinary Respiratory Medicine)
Source: Multidisciplinary Respiratory Medicine - April 29, 2016 Category: Respiratory Medicine Source Type: research

Tracheobronchopathia Osteochondroplastica: a rare case report of a non-smoker and non-atopic patient, with a long history of wheezing since childhood
Conclusion TBPO is a rare disease characterized by wheezing, cough, hemoptysis, and recurrent pulmonary infections, with typical onset during adulthood. In the case reported, the symptoms began in childhood, although they had been misinterpreted as asthma. Even if childhood-onset is not reported in literature, it is likely that small changes occur in the first few years of life and become more evident in adulthood. The involvement of segmental and sub-segmental bronchi, usually spared in TBPO, could explain the presence of wheezing and non-productive cough reported by our patient since childhood. (Sou...
Source: Multidisciplinary Respiratory Medicine - April 18, 2016 Category: Respiratory Medicine Source Type: research

Increased expression of A Proliferation-inducing Ligand (APRIL) in lung leukocytes and alveolar epithelial cells in COPD patients with non small cell lung cancer: a possible link between COPD and lung cancer?
Conclusion The percentage of APRIL-expressing B cells, AMs and AECs is higher in the lungs of patients with both COPD and NSCLC than in patients with COPD or NSCLC alone or control subjects. These findings suggest that APRIL may contribute to the pathogenesis of both COPD and NSCLC, and possibly to the development of NSCLC in patients with established COPD. (Source: Multidisciplinary Respiratory Medicine)
Source: Multidisciplinary Respiratory Medicine - April 3, 2016 Category: Respiratory Medicine Source Type: research

Does homeopathic medicine have a preventive effect on respiratory tract infections? A real life observational study
Conclusion These results suggest that homeopathic medicine may have a positive effect in preventing RTIs. However, randomized studies are needed before any firm conclusion can be reached. (Source: Multidisciplinary Respiratory Medicine)
Source: Multidisciplinary Respiratory Medicine - March 20, 2016 Category: Respiratory Medicine Source Type: research

COPD heterogeneity: implications for management
(Source: Multidisciplinary Respiratory Medicine)
Source: Multidisciplinary Respiratory Medicine - March 16, 2016 Category: Respiratory Medicine Source Type: research

The BODECOST Index (BCI): a composite index for assessing the impact of COPD in real life
Conclusions BCI is a novel composite index which helps in predicting the impact of COPD at 3 years in real life, both in terms of patients’ survival and of COPD economic burden. (Source: Multidisciplinary Respiratory Medicine)
Source: Multidisciplinary Respiratory Medicine - March 3, 2016 Category: Respiratory Medicine Source Type: research

Differentiation of respiratory epithelium in a 3-dimensional co-culture with fibroblasts embedded in fibrin gel
Conclusions This study indicates that adding fibroblasts to fibrin gel positively influences the differentiation of respiratory epithelium. (Source: Multidisciplinary Respiratory Medicine)
Source: Multidisciplinary Respiratory Medicine - March 1, 2016 Category: Respiratory Medicine Source Type: research

Chronic respiratory symptoms and associated factors among cement factory workers in Dejen town, Amhara regional state, Ethiopia, 2015
Conclusion Chronic respiratory symptoms were highly prevalent among Dejen cement factory workers. Age, sex, education level, working department, smoking, work experience, and training were identified factors. Pre employment and on service training, smoking cessation programs, improving hygienic practices are important tasks in order to maintain the health and safety of workers. (Source: Multidisciplinary Respiratory Medicine)
Source: Multidisciplinary Respiratory Medicine - March 1, 2016 Category: Respiratory Medicine Source Type: research

Erratum to: Particulate matters from diesel heavy duty trucks exhaust versus cigarettes emissions: a new educational antismoking instrument
(Source: Multidisciplinary Respiratory Medicine)
Source: Multidisciplinary Respiratory Medicine - February 16, 2016 Category: Respiratory Medicine Source Type: research

Health-related quality of life measurement in asthma and chronic obstructive pulmonary disease: review of the 2009-2014 literature
Conclusions There are some methodology aspects that should be discussed in more depth, for example the necessity to express variations in the subjective perception, not as p-value but as effect-size. (Source: Multidisciplinary Respiratory Medicine)
Source: Multidisciplinary Respiratory Medicine - February 15, 2016 Category: Respiratory Medicine Source Type: research

Reviewer acknowledgement 2015
Contributing reviewers The editors of Multidisciplinary Respiratory Medicine would like to thank all of our reviewers who have contributed to the journal in Volume 10 (2015). (Source: Multidisciplinary Respiratory Medicine)
Source: Multidisciplinary Respiratory Medicine - February 11, 2016 Category: Respiratory Medicine Source Type: research

Acceptability and preference of three inhalation devices assessed by the Handling Questionnaire in asthma and COPD patients
Conclusions Substantial differences are existing in patient’s preference and acceptability for inhalation devices, mainly related to the handling and the understanding of the different devices. (Source: Multidisciplinary Respiratory Medicine)
Source: Multidisciplinary Respiratory Medicine - February 10, 2016 Category: Respiratory Medicine Source Type: research

N-acetylcysteine in COPD: why, how, and when?
Abstract Oxidants have long been recognized to have an important role in the pathogenesis of COPD, and in this cigarette smoke has a strong responsibility, because it generates a conspicuous amount of oxidant radicals able to modify the structure of the respiratory tract and to enhance several mechanisms that sustain lung inflammation in COPD. In fact, oxidative stress is highly increased in COPD and natural antioxidant capacities, mainly afforded by reduced glutathione, are often overcome. Thus an exogenous supplementation of antioxidant compounds is mandatory to at least partially counteract the oxida...
Source: Multidisciplinary Respiratory Medicine - February 3, 2016 Category: Respiratory Medicine Source Type: research

The assessment of new drugs for asthma and COPD: a Delphi study examining the perspectives of Italian payers and clinicians
Conclusion The final document highlights that no proof of difference among drugs exists, that evidence on final endpoints (and particularly on mortality) should be strengthened and that actions regarding risk factors, appropriate diagnosis, patient staging and adherence to therapy are particularly important for a better clinical management. (Source: Multidisciplinary Respiratory Medicine)
Source: Multidisciplinary Respiratory Medicine - January 27, 2016 Category: Respiratory Medicine Source Type: research

Particulate matters from diesel heavy duty trucks exhaust versus cigarettes emissions: a new educational antismoking instrument
Conclusions Our findings may be important for policies that aim reducing outdoor SHS exposure. They may also help smokers to quit tobacco dependence by giving them an educational perspective that rebuts the common alibi that traffic pollution is more dangerous than cigarettes pollution. (Source: Multidisciplinary Respiratory Medicine)
Source: Multidisciplinary Respiratory Medicine - January 22, 2016 Category: Respiratory Medicine Source Type: research