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Bibliometric analysis of worldwide publications on multi-, extensively, and totally drug – resistant tuberculosis (2006–2015)
ConclusionPublications on MDR, XDR and TDR – TB are increasing in the past decade. International collaboration was common. Many low resourced African and Asian countries will benefit from research leading to new diagnostic and screening technology of TB. The exchange of expertise, ideas and technology is of paramount importance in this fie ld. (Source: Multidisciplinary Respiratory Medicine)
Source: Multidisciplinary Respiratory Medicine - January 10, 2017 Category: Respiratory Medicine Source Type: research

Cost of persistent asthma in Italy
ConclusionsThe periodic update of cost analysis is a key to monitor the trend of main asthma outcomes and related expenditure over time. It allows to plan the most convenient actions in terms of prevention strategies and effective interventions, with the aim of optimizing the healthcare resources consumption and maximizing the impact on clinical outcomes and patients ’ quality of life. The role of an appropriate pharmacological strategy still proves crucial in minimizing asthma morbidity and the corresponding socio-economic impact. (Source: Multidisciplinary Respiratory Medicine)
Source: Multidisciplinary Respiratory Medicine - December 15, 2016 Category: Respiratory Medicine Source Type: research

DNA damage and repair capacity in lymphocyte of chronic obstructive pulmonary diseases patients during physical exercise with oxygen supplementation
ConclusionCOPD patients who performed physical exercise associated with oxygen supplementation had a better response to DNA damage induced by MMS and a better DNA repair when compared to the condition of physical exercise without oxygen supplementation.Trial registrationUNISC N374.298. Registered 04 JUN 2013 (retrospectively registered). (Source: Multidisciplinary Respiratory Medicine)
Source: Multidisciplinary Respiratory Medicine - December 13, 2016 Category: Respiratory Medicine Source Type: research

Personality and unachieved treatment goals related to poor adherence to asthma medication in a newly developed adherence questionnaire – a population-based study
ConclusionsThe developed questionnaire appears to be useful for measuring adherence to asthma medication in adult individuals with asthma. The study suggests that both individual differences and personal treatment goals need to be addressed in efforts to promote adherence to asthma medication treatment. (Source: Multidisciplinary Respiratory Medicine)
Source: Multidisciplinary Respiratory Medicine - December 4, 2016 Category: Respiratory Medicine Source Type: research

Hemothorax following lung transplantation: incidence, risk factors, and effect on morbidity and mortality
ConclusionThe development of hemothorax is associated with increased morbidity and decreased short-term survival. Hemothorax may present either within the first 48  h after surgery or in a delayed fashion, most commonly in the setting of anticoagulation. (Source: Multidisciplinary Respiratory Medicine)
Source: Multidisciplinary Respiratory Medicine - November 14, 2016 Category: Respiratory Medicine Source Type: research

Respiratory illness and air pollution from the steel industry: the case of Piqui á de Baixo, Brazil (Preliminary report)
ConclusionsIn light of the above considerations, we believe that our findings contribute to the existing literature on the correlation between pulmonary disease and air pollution in industrialized areas, while warranting further scientific research on the public health consequences of industrial production in Piqui á de Baixo. In turn, on the ethical plane, we believe that research of this nature strengthens the need to advocate for more severe environmental and health policies aimed at limiting the hazards associated with the steel industry in Piquiá and in similar contexts around the world. (Source: Multidisciplinary Respiratory Medicine)
Source: Multidisciplinary Respiratory Medicine - November 8, 2016 Category: Respiratory Medicine Source Type: research

Efficacy of recombinant human soluble thrombomodulin for the treatment of acute exacerbation of idiopathic pulmonary fibrosis: a single arm, non-randomized prospective clinical trial
ConclusionrhTM plus steroid pulse therapy improves respiratory functions in patients with AE-IPF and is expected to improve overall patient survival without using other combination therapies.Trial registrationThe study was registered with University Hospital Medical Information Network Clinical Trial Registry (UMIN-CTR) in October 2012 (UMIN000009082). (Source: Multidisciplinary Respiratory Medicine)
Source: Multidisciplinary Respiratory Medicine - November 6, 2016 Category: Respiratory Medicine Source Type: research

Cost comparison of asthma treatments in 12-week study: caution about matching and short observational follow-up
AbstractIn the absence of randomisation, observational studies must take extra care to create treatment groups that are comparable in terms of key characteristics. Various matching methods exist which can create sound comparisons, minimising confounding where possible. A recent observational study by Dal Negro et al. carried out a cost analysis comparing two asthma medications. They report strong conclusions which favour one treatment over the other, however they include little discussion on the limitations of their study. The purpose of this letter is to comment on the weaknesses of the study design, including the level o...
Source: Multidisciplinary Respiratory Medicine - November 1, 2016 Category: Respiratory Medicine Source Type: research

Asthma-related deaths
AbstractDespite major advances in the treatment of asthma and the development of several asthma guidelines, people still die of asthma currently. According to WHO estimates, approximately 250,000 people die prematurely each year from asthma. Trends of asthma mortality rates vary very widely across countries, age and ethnic groups. Several risk factors have been associated with asthma mortality, including a history of near-fatal asthma requiring intubation and mechanical ventilation, hospitalization or emergency care visit for asthma in the past year, currently using or having recently stopped using oral corticosteroids (a ...
Source: Multidisciplinary Respiratory Medicine - October 11, 2016 Category: Respiratory Medicine Source Type: research

The effect of positive airway pressure therapy on neurocognitive functions, depression and anxiety in obesity hypoventilation syndrome
ConclusionsCognitive dysfunction, depression and anxiety are important under-recognized comorbidities in OHS. It is suggested that short term PAP therapy had positive effects on neurocognitive functions, depression and anxiety but further multicentre, prospective studies with large number of cases are needed to evaluate the effect of long term PAP therapy on these parameters. (Source: Multidisciplinary Respiratory Medicine)
Source: Multidisciplinary Respiratory Medicine - October 10, 2016 Category: Respiratory Medicine Source Type: research

Preliminary study on the assessment of visceral adipose tissue using dual-energy x-ray absorptiometry in chronic obstructive pulmonary disease
ConclusionAfter stratification for BMI, VAT is comparable in moderate to very severe COPD patients. Furthermore, BMI and demographics, but not VAT, were independent predictors of static lung hyperinflation and diffusing capacity in COPD. (Source: Multidisciplinary Respiratory Medicine)
Source: Multidisciplinary Respiratory Medicine - October 3, 2016 Category: Respiratory Medicine Source Type: research

Cough: impact, beliefs, and expectations from a national survey
ConclusionsCough confirms its high impact in Italy, and a substantial proportion of individuals regards cough as “a disease”. Only one out of three Italians refers to their doctor, but when cough is already persistent. Cough in children is much more feared than in adults. The majority of Italians have a proper and conservative position versus both antibiotic and the systemic steroid uses against cough. The Italian attitude to aerosol therapy confirms very high. Differently from the cough guidelines, anti-tussive drugs are highly valued among Italian people. The attitude and the interest to homeopathic anti-tussive reme...
Source: Multidisciplinary Respiratory Medicine - September 26, 2016 Category: Respiratory Medicine Source Type: research

Lung disease recalling paraseptal emphysema in a patient with Goltz syndrome
ConclusionThis report suggested - for the first time time - a rationale for a lung function and imaging screening in patients affected by Goltz syndrome at least in its autosomal form. (Source: Multidisciplinary Respiratory Medicine)
Source: Multidisciplinary Respiratory Medicine - September 12, 2016 Category: Respiratory Medicine Source Type: research

Dry-powder inhalers in patients with persistent airflow limitation: usability and preference
ConclusionsThe possibility of grading objectively the performance of different DPIs in terms of their usability and therapeutic convenience in daily life represents a crucial operational opportunity to pursue. To note that a substantial discrepancy  exists between the patients’ belief “at glance” and the patients’ effective usability with can be registered with some devices. From a general point of view, devices requiring less manual actions for their actuation confirmed their better usability and proper handling after less attempts. In particular, Genuair came out as the most preferred DPI also when several diffe...
Source: Multidisciplinary Respiratory Medicine - September 4, 2016 Category: Respiratory Medicine Source Type: research

Cultural and linguistic validation of the NHQ-2 Questionnaire: a specific instrument for assessing patient ’s usability of inhalation devices
ConclusionsThe novel NHQ-2 questionnaire proved very high comprehensibility and reproducibility in both its Italian and English final versions. It can be proposed for the trans-cultural clinical use when the usability, and not only the patients ’ preference of devices, should be assessed. (Source: Multidisciplinary Respiratory Medicine)
Source: Multidisciplinary Respiratory Medicine - August 22, 2016 Category: Respiratory Medicine Source Type: research