A systematic review of neuroprotective strategies after cardiac arrest: from bench to bedside (part II-comprehensive protection)
Abstract
Neurocognitive deficits remain a significant source of morbidity in survivors of cardiac arrest. We conducted a literature review of treatment protocols designed to evaluate neurologic outcome and survival following global cerebral ischemia associated with cardiac arrest. The search was limited to investigational therapies that were implemented either during cardiopulmonary resuscitation or after return of spontaneous circulation in studies that included assessment of impact on neurologic outcome. Given that complex pathophysiology underlies global brain hypoxic ischemia following cardiac arres...
Source: Medical Gas Research - May 20, 2014 Category: Biomedical Science Source Type: research
A systematic review of neuroprotective strategies after cardiac arrest: from bench to bedside (Part I – Protection via specific pathways)
Abstract
Neurocognitive deficits are a major source of morbidity in survivors of cardiac arrest. Treatment options that could be implemented either during cardiopulmonary resuscitation or after return of spontaneous circulation to improve these neurological deficits are limited. We conducted a literature review of treatment protocols designed to evaluate neurologic outcome and survival following cardiac arrest with associated global cerebral ischemia. The search was limited to investigational therapies that were utilized to treat global cerebral ischemia associated with cardiac arrest. In this review we...
Source: Medical Gas Research - May 1, 2014 Category: Biomedical Science Source Type: research
Hyperbaric oxygen therapy for chronic post-concussive syndrome
Abstract
In this editorial, the value of hyperbaric oxygen therapy in the management of chronic post-concussive syndrome following mild traumatic brain injury is discussed. (Source: Medical Gas Research)
Source: Medical Gas Research - April 9, 2014 Category: Biomedical Science Source Type: research
The development of hyperbaric oxygen therapy for skin rejuvenation and treatment of photoaging
Abstract
Hyperbaric oxygen therapy (HBOT), a therapy that have patients breath in pure oxygen in a pressurized chamber, has been long used as a treatment for conditions such as decompression sickness and carbon monoxide poisoning. Oxygen recently has been found to be an important component in skin rejuvenation, treatment of photoaging skin, and improvement in skin complexions. The interest in the use of HBOT for this purpose is continually growing and becoming more widespread. In addition to aging and genetic makeup, chronic UV radiation due to everyday exposure, especially UV-B, can greatly increase th...
Source: Medical Gas Research - April 1, 2014 Category: Biomedical Science Source Type: research
Cognitive dysfunction following desflurane versus sevoflurane general anesthesia in elderly patients: a randomized controlled trial
Conclusions
For elderly patients in whom depth of anesthesia is maintained in the moderate range, both desflurane and sevoflurane are associated with transient decreases in cognitive function as measured by MMSE after anesthesia, with clinically insignificant differences between them in this setting.
Trial registry
ClinicalTrials.gov NCT01199913 (Source: Medical Gas Research)
Source: Medical Gas Research - March 25, 2014 Category: Biomedical Science Source Type: research
In vitro Activation of heme oxygenase-2 by menadione and its analogs
Conclusions
These observations are consistent with the idea that naphthoquinones such as menadione bind to a receptor in HO-2 and activate the enzyme through a mechanism that may involve redox properties. (Source: Medical Gas Research)
Source: Medical Gas Research - February 18, 2014 Category: Biomedical Science Source Type: research
Adverse effect of inhalational anesthetics on the developing brain
Abstract
We did a PubMed search and summarized studies on the potential adverse effect of anesthetics especially neurotoxicity in the developing brain, so named anesthesia-induced developmental neurotoxicity. Even though many experimental studies using animal models indicated some adverse effect of anesthetics, more evidence is needed before a recommendation can be made to change the way those anesthetics are used in the pediatric population. Two large clinical trials are underway and may provide insight to the potential human neurotoxic effect of anesthetics. (Source: Medical Gas Research)
Source: Medical Gas Research - February 14, 2014 Category: Biomedical Science Source Type: research
Variability in uptake efficiency for pulsed versus constant concentration delivery of inhaled nitric oxide
Conclusions
Pulsed NO delivery improves uptake efficiency compared with constant concentration delivery. Optimization of pulse timing is critical in limiting intra- and inter-subject variability in dosing. (Source: Medical Gas Research)
Source: Medical Gas Research - January 22, 2014 Category: Biomedical Science Source Type: research
Amelioration of cardio-renal injury with aging in dahl salt-sensitive rats by H 2 -enriched electrolyzed water
Conclusion
Long-term ad libitum consumption of H2-enriched electrolyzed water can ameliorate the processes of kidney injury and cardiac remodeling with aging in Dahl SS rats by suppressing, at least partly, elevated inflammation and oxidative stress. (Source: Medical Gas Research)
Source: Medical Gas Research - December 2, 2013 Category: Biomedical Science Source Type: research
Amelioration of cardio-renal injury with aging in dahl salt-sensitive rats by H2-enriched electrolyzed water
Conclusion
Long-term ad libitum consumption of H2-enriched electrolyzed water can ameliorate the processes of kidney injury and cardiac remodeling with aging in Dahl SS rats by suppressing, at least partly, elevated inflammation and oxidative stress. (Source: Medical Gas Research)
Source: Medical Gas Research - December 2, 2013 Category: Biomedical Science Source Type: research
Hypocapnia as a poor prognostic factor in aneurysmal subarachnoid hemorrhage
Abstract
In this editorial, the issues of hypocapnia and its relation to symptomatic vasospasm, prognosis, and outcome among patients with aneurysmal subarachnoid hemorrhage is discussed. Potential directions for future studies are provided. (Source: Medical Gas Research)
Source: Medical Gas Research - November 25, 2013 Category: Biomedical Science Source Type: research
A comparative study on the anti-inflammatory effects of single oral doses of naproxen and its hydrogen sulfide (H2S)-releasing derivative ATB-346 in rats with carrageenan-induced synovitis
Conclusion
The presence of a H2S-releasing moiety in the ATB-346 structure does not impair the antiinflammatory activity of the parent compound in rats with CGN-induced synovitis. In addition, released H2S may account for the absence of deleterious gastric effects, thus making of ATB-346 a potentially useful therapeutic alternative to traditional naproxen for treatment of patients with arthritis. (Source: Medical Gas Research)
Source: Medical Gas Research - November 16, 2013 Category: Biomedical Science Source Type: research
Hypercapnia: is it protective in lung injury?
Abstract
Hypercapnic acidosis has been regarded as a tolerated side effect of protective lung ventilation strategies. Various in vivo and ex vivo animal studies have shown beneficial effects in acute lung injury setting, but some recent work raised concerns about its anti-inflammatory properties. This mini-review article aims to expand the potential clinical spectrum of hypercapnic acidosis in critically ill patients with lung injury. Despite the proven benefits of hypercapnic acidosis, further safety studies including dose-effect, level-and-onset of anti-inflammatory effect, and safe applicability peri...
Source: Medical Gas Research - November 11, 2013 Category: Biomedical Science Source Type: research
Bustling argon: biological effect
Abstract
Argon is a noble gas in group 18 of the periodic table. Certificated to exist in air atmosphere merely one century ago, discovery of argon shows interesting stories of researching and exploring. It was assumed to have no chemical activity. However, argon indeed present its biological effect on mammals. Narcotic effect of argon in diving operation and neur-protective function of argon in cerebral injury demonstrate that argon has crucial effect and be concentrated on is necessary. Furthermore, consider to be harmless to human, argon clinical application in therapy would be another option. (Sourc...
Source: Medical Gas Research - October 3, 2013 Category: Biomedical Science Source Type: research
The role of helium gas in medicine
Abstract
The noble gas helium has many applications owing to its distinct physical and chemical characteristics, namely: its low density, low solubility, and high thermal conductivity. Chiefly, the abundance of studies in medicine relating to helium are concentrated in its possibility of being used as an adjunct therapy in a number of respiratory ailments such as asthma exacerbation, COPD, ARDS, croup, and bronchiolitis. Helium gas, once believed to be biologically inert, has been recently shown to be beneficial in protecting the myocardium from ischemia by various mechanisms. Though neuroprotection of ...
Source: Medical Gas Research - August 4, 2013 Category: Biomedical Science Source Type: research
