[Obituary] Gerald Reaven
Pioneer of insulin resistance and endocrinologist credited with identifying the metabolic syndrome. He was born in Gary, IN, USA, on July 28, 1928, and died on Feb 12, 2018, in Stanford, CA, USA, aged 89 years. (Source: LANCET)
Source: LANCET - April 27, 2018 Category: General Medicine Authors: Ivan Oransky, Adam Marcus Tags: Obituary Source Type: research

[World Report] Concern for human rights in Turkey as Erdo ğan plans election
Experts from the UN, European Union, and USA deplore reversing progress on human rights in Turkey, as Erdo ğan calls for a snap presidential election in June. Sharmila Devi reports. (Source: LANCET)
Source: LANCET - April 27, 2018 Category: General Medicine Authors: Sharmila Devi Tags: World Report Source Type: research

[World Report] Scientists and physicians run for office in the USA
Frustrated by what they say is the US Government's disregard for science, more scientists and physicians are entering politics. Susan Jaffe, The Lancet's Washington correspondent, reports. (Source: LANCET)
Source: LANCET - April 27, 2018 Category: General Medicine Authors: Susan Jaffe Tags: World Report Source Type: research

[Comment] Offline: Towards a Pax Sinica?
One's immediate impression on meeting China's new Minister of Health, Ma Xiaowei, is his sense of humour. Laughter frequently punctuates his sentences. He discusses his love of Agatha Christie. Minister Ma has worked in the National Health Commission (Ministry of Health) for two decades. He knows the job and understands its enormous responsibilities. We met on what he pointed out was his 1-month anniversary in the role. Now is “a very critical period” for the health of the Chinese people. He identified two priorities. (Source: LANCET)
Source: LANCET - April 27, 2018 Category: General Medicine Authors: Richard Horton Tags: Comment Source Type: research

[Comment] Excess oxygen in acute illness: adding fuel to the fire
Oxygen is essential for life and is the third most abundant element in the universe. This abundance is evident in the treatment of acutely ill adults admitted to intensive and progressive care units around the world, in whom excess oxygen is frequently provided for inhalation. The typical motivation for liberal oxygen administration is the prevention of hypoxaemia. By contrast, few health-care providers are concerned about hyperoxaemia —ie, highly elevated arterial oxygen concentrations (arterial oxygen tension>100 mm Hg). (Source: LANCET)
Source: LANCET - April 27, 2018 Category: General Medicine Authors: John W McEvoy Tags: Comment Source Type: research

[Comment] Transcranial magnetic stimulation for depression
Depression is a common and disabling condition that is the leading single cause of disability in high-income and middle-income countries. There is good evidence that antidepressants and psychotherapies, such as cognitive behavioural therapy (CBT), are effective treatments. However, many people do not respond to these treatments. Only about 30% of people respond to a 3-month course of antidepressants1 and, in the CoBalT study2 of people who had not responded to antidepressants, about half also did not respond to CBT. (Source: LANCET)
Source: LANCET - April 27, 2018 Category: General Medicine Authors: Glyn Lewis Tags: Comment Source Type: research

[Editorial] Solitary confinement of children and young people
Last week, in a joint statement, the British Medical Association (BMA), the Royal College of Psychiatrists, and the Royal College of Paediatrics and Child Health called for an end to the solitary confinement of children and young people held in UK detention facilities. According to a survey from the HM Inspectorate of Prisons, 38% of boys detained in the UK have spent time in solitary confinement, physically and socially isolated from others, with almost no purposeful interaction or environmental stimuli, for periods that can stretch for up to 80 days. (Source: LANCET)
Source: LANCET - April 27, 2018 Category: General Medicine Authors: The Lancet Tags: Editorial Source Type: research

[Editorial] Addressing decreasing vaccine coverage in the EU
In recent years, the European Union (EU) has seen large outbreaks of vaccine-preventable diseases such as measles due to declining vaccine coverage, supply shortages, and growing vaccine hesitancy. To address the challenges facing vaccination programmes, the European Commission set an ambitious goal: to put together a Recommendation to strengthen cooperation against vaccine-preventable diseases in EU countries. A roadmap for the Recommendation was published on Dec 4, 2017, and was opened for public consultation for 4 weeks. (Source: LANCET)
Source: LANCET - April 27, 2018 Category: General Medicine Authors: The Lancet Tags: Editorial Source Type: research

[Editorial] Making more of multimorbidity: an emerging priority
Multimorbidity would seem a relatively straightforward term, denoting multiple medical conditions within a single patient. Yet an Academy of Medical Sciences report, Multimorbidity: a priority for global health research, published in April, 2018, suggests that competing definitions in the medical literature have impeded research and improvements in patient care. The report recommends that a path forward must include a standardised definition that can be incorporated into research agendas to identify the evidence gaps and to inform the organisation of health-care systems globally. (Source: LANCET)
Source: LANCET - April 27, 2018 Category: General Medicine Authors: The Lancet Tags: Editorial Source Type: research

[Department of Error] Department of Error
Sperber A. Mediators help migrants access health services in Italy. Lancet 2018; 391: 1468 –69—In this World Report, the name of one contributor, Ousmane Thiam, was occasionally misspelled. The online version has been corrected as of April 27, 2018. (Source: LANCET)
Source: LANCET - April 27, 2018 Category: General Medicine Tags: Department of Error Source Type: research

[Articles] Development and validation of a Hospital Frailty Risk Score focusing on older people in acute care settings using electronic hospital records: an observational study
The Hospital Frailty Risk Score provides hospitals and health systems with a low-cost, systematic way to screen for frailty and identify a group of patients who are at greater risk of adverse outcomes and for whom a frailty-attuned approach might be useful. (Source: LANCET)
Source: LANCET - April 26, 2018 Category: General Medicine Authors: Thomas Gilbert, Jenny Neuburger, Joshua Kraindler, Eilis Keeble, Paul Smith, Cono Ariti, Sandeepa Arora, Andrew Street, Stuart Parker, Helen C Roberts, Martin Bardsley, Simon Conroy Tags: Articles Source Type: research

[Comment] What proportion of older adults in hospital are frail?
Despite the increasing level of knowledge about individual illnesses, modern health-care systems seem lost when seeing patients whose diseases come not one at a time, but all at once —especially when they come with equally complex social needs. Although some geriatricians proclaimed the end of the disease era1 to focus on the complexity of frailty in geriatric assessment,2 the argument is falling flat. Disease-focused specialists who push on with the only course they know some times decry their frail patients as being unsuitable or requiring social support or failing to cope or thrive. (Source: LANCET)
Source: LANCET - April 26, 2018 Category: General Medicine Authors: Samuel D Searle, Kenneth Rockwood Tags: Comment Source Type: research

[Articles] Effect of generalised access to early diagnosis and treatment and targeted mass drug administration on Plasmodium falciparum malaria in Eastern Myanmar: an observational study of a regional elimination programme
Providing early diagnosis and effective treatment substantially decreased village-level incidence of artemisinin-resistant P falciparum malaria in hard-to-reach, politically sensitive regions of eastern Myanmar. Targeted mass drug administration significantly reduced malaria incidence in hotspots. If these activities could proceed in all contiguous endemic areas in addition to standard control programmes already implemented, there is a possibility of subnational elimination of P falciparum. (Source: LANCET)
Source: LANCET - April 24, 2018 Category: General Medicine Authors: Jordi Landier, Daniel M Parker, Aung Myint Thu, Khin Maung Lwin, Gilles Delmas, Fran çois H Nosten, Malaria Elimination Task Force Group Tags: Articles Source Type: research

[Comment] Can improving access to care help to eliminate malaria?
Malaria remains a major cause of morbidity and mortality throughout the world, with 32% of the world's population living in areas of risk.1 Despite the progress that has been made in reducing the burden of malaria through improved access to preventive interventions,1 there remain many challenges to the eventual eradication of the parasite. Perhaps one of the greatest challenges is the continual battle with resistance, to both the drugs used to treat the cases and the insecticides used to kill the mosquito hosts. (Source: LANCET)
Source: LANCET - April 24, 2018 Category: General Medicine Authors: Azra C Ghani Tags: Comment Source Type: research

[Department of Error] Department of Error
Chen I, Cooney R, Feachem RGA, Lal A, Mpanju-Shumbusho W. The Lancet Commission on malaria eradication. Lancet 2018; 391: 1556 –58—In this Comment (published online first on April 16, 2018), the affiliation for Winnie Mpanju-Shumbusho should be RBM Partnership to End Malaria, and the weblink should be RBM Partnership to End Malaria. These corrections have been made to the online version as of April 19, 2018, and the pri nted Comment is correct. (Source: LANCET)
Source: LANCET - April 19, 2018 Category: General Medicine Tags: Department of Error Source Type: research