[Articles] Effectiveness of theta burst versus high-frequency repetitive transcranial magnetic stimulation in patients with depression (THREE-D): a randomised non-inferiority trial
In patients with treatment-resistant depression, iTBS was non-inferior to 10 Hz rTMS for the treatment of depression. Both treatments had low numbers of dropouts and similar side-effects, safety, and tolerability profiles. By use of iTBS, the number of patients treated per day with current rTMS devices can be increased several times without compromising clinical effectiveness. (Source: LANCET)
Source: LANCET - April 27, 2018 Category: General Medicine Authors: Daniel M Blumberger, Fidel Vila-Rodriguez, Kevin E Thorpe, Kfir Feffer, Yoshihiro Noda, Peter Giacobbe, Yuliya Knyahnytska, Sidney H Kennedy, Raymond W Lam, Zafiris J Daskalakis, Jonathan Downar Tags: Articles Source Type: research
[Correspondence] Port-of-Spain Declaration for global NCD prevention
As global health researchers who work on non-communicable diseases (NCDs) and global health diplomacy, we were delighted to see the prioritisation of and emphasis on a global commitment to tackle the epidemic of NCDs in the Comment1 by Sania Nishtar (Oct 21, p 1820). Nishtar suggests excellent strategies, such as a multi stakeholder structure to serve as a holistic platform, to enable transparency and accountability to negotiate policy space for NCDs. Nishtar also highlights that none of the more than 80 disease-specific partnerships that have been created holistically address NCDs, and that this requires a multisectoral, ...
Source: LANCET - April 27, 2018 Category: General Medicine Authors: Vijay Kumar Chattu, Sateesh Sakhamuri Tags: Correspondence Source Type: research
[Correspondence] Associations of fats and carbohydrates with cardiovascular disease and mortality —PURE and simple? – Authors' reply
We concur with Jim Mann and colleagues that dietary recommendations should be informed with all available evidence, and that ideally large randomised trials on clinical outcomes should be used. In the absence of randomised trials, large, well designed observational studies on clinical outcomes provide the next best type of evidence. Our results are consistent with previous observational studies1 that showed no harm with high fat intake —even when mean fat intake was higher than in the Prospective Urban Rural Epidemiological (PURE) study. (Source: LANCET)
Source: LANCET - April 27, 2018 Category: General Medicine Authors: Mahshid Dehghan, Andrew Mente, Salim Yusuf Tags: Correspondence Source Type: research
[Correspondence] Associations of fats and carbohydrates with cardiovascular disease and mortality —PURE and simple?
The Prospective Urban Rural Epidemiological (PURE) study,1 which included 18 cohorts from low-income, middle-income, and high-income countries worldwide, reported that high carbohydrate intake was associated with an increased risk of total mortality, whereas high intake of total fat and individual types of fat were associated with reduced total mortality. These results contribute valuable evidence to the field of nutrition, but using questionnaires to infer the amount, quality, and composition of intake of fats is error prone because of the complexity of foods and the possibility of implausible questionnaire entries. (Source: LANCET)
Source: LANCET - April 27, 2018 Category: General Medicine Authors: Marcus E Kleber, Graciela E Delgado, Christine Dawczynski, Stefan Lorkowski, Winfried M ärz Tags: Correspondence Source Type: research
[Correspondence] Associations of fats and carbohydrates with cardiovascular disease and mortality —PURE and simple?
In The Lancet, Mahshid Dehghan and colleagues1 reported a positive association between carbohydrate intake and non-cardiovascular mortality, and an unexpected inverse association between non-cardiovascular mortality and saturated fat intake. The authors recommended changes in dietary guidelines on the basis of assumed causality. (Source: LANCET)
Source: LANCET - April 27, 2018 Category: General Medicine Authors: Boris Hansel, Ronan Roussel, Philippe Giral Tags: Correspondence Source Type: research
[Correspondence] Associations of fats and carbohydrates with cardiovascular disease and mortality —PURE and simple?
The Prospective Urban Rural Epidemiological (PURE) study1 has attracted considerable attention in both academia and the public domain. The conclusions of the study challenge the dietary advice and guidelines people have adhered to for decades. Scholars have questioned the accuracy of macronutrient distribution data reported in the PURE study for the Chinese population. The study reported that about 77% of the population in China consume at least 60% of energy from carbohydrate and 43% of individuals consume at least 70% of energy from carbohydrate, with a mean of 67 ·0% energy derived from carbohydrate and 17·7% from fat. (Source: LANCET)
Source: LANCET - April 27, 2018 Category: General Medicine Authors: Xi-Peng Cao, Chen-Chen Tan, Jin-Tai Yu Tags: Correspondence Source Type: research
[Correspondence] Associations of fats and carbohydrates with cardiovascular disease and mortality —PURE and simple?
We congratulate Mahshid Dehghan and colleagues on the Prospective Urban Rural Epidemiological (PURE) study.1 Their results are consistent with evidence suggesting that a diet high in fat might reduce mortality2 and incidence of cardiovascular disease.3 (Source: LANCET)
Source: LANCET - April 27, 2018 Category: General Medicine Authors: Salvatore Carbone, Hayley Billingsley, Antonio Abbate Tags: Correspondence Source Type: research
[Correspondence] Associations of fats and carbohydrates with cardiovascular disease and mortality —PURE and simple?
The Prospective Urban Rural Epidemiological (PURE) study1 investigators did outstanding work, but we have concerns regarding data presentation and interpretation. (Source: LANCET)
Source: LANCET - April 27, 2018 Category: General Medicine Authors: Stefan Lorkowski, Margrit Richter, Jakob Linseisen, Bernhard Watzl, German Nutrition Society Tags: Correspondence Source Type: research
[Correspondence] Associations of fats and carbohydrates with cardiovascular disease and mortality —PURE and simple?
As intake of dietary fat remains a topic of intense debate,1,2 both in the scientific field and the media, epidemics of type 2 diabetes and coronary heart disease in some low-income countries threaten to become pandemic.3 Scholars, including the authors of the Prospective Urban Rural Epidemiological (PURE) study,4 warn that guidelines on dietary fat have been made on the basis of observational data, which should not be relied on. In India, clinical and public health professionals trying to prevent and control type 2 diabetes and coronary heart disease have developed guidelines and interventions using risk factors, includin...
Source: LANCET - April 27, 2018 Category: General Medicine Authors: Raj S Bhopal, Anoop Misra Tags: Correspondence Source Type: research
[Correspondence] Associations of fats and carbohydrates with cardiovascular disease and mortality —PURE and simple?
The Prospective Urban Rural Epidemiological (PURE) investigators previously published ecological analyses showing that total and cardiovascular mortality was substantially higher in low-income countries than in high-income countries (total mortality hazard ratio [HR] 3 ·66 and cardiovascular mortality HR 6·05).1 (Source: LANCET)
Source: LANCET - April 27, 2018 Category: General Medicine Authors: Jacques E Rossouw, Ross L Prentice Tags: Correspondence Source Type: research
[Correspondence] Associations of fats and carbohydrates with cardiovascular disease and mortality —PURE and simple?
It is better to be rich and healthy than poor and sick: this is the main conclusion from a study1 by Mahshid Dehghan and colleagues published in The Lancet. In the Prospective Urban Rural Epidemiological (PURE) study, investigators examined nutrition and disease in 18 countries, focusing on understudied regions. More than 135 000 participants were enrolled between 2003 and 2013, with a median follow-up of 7·4 years. (Source: LANCET)
Source: LANCET - April 27, 2018 Category: General Medicine Authors: Hana Kahleova, Lee Crosby, Susan Levin, Neal D Barnard Tags: Correspondence Source Type: research
[Correspondence] Associations of fats and carbohydrates with cardiovascular disease and mortality —PURE and simple?
Much has been said on the results from the Prospective Urban Rural Epidemiological (PURE) study by Mahshid Dehghan and colleagues.1 Data from 18 countries are represented, providing a valuable contribution to the body of prospective observational evidence. PURE is not the largest, most comprehensive, or longest running cohort study; however, the diverse sampling method is a valuable addition to nutrition epidemiology, should the PURE data be found usable. (Source: LANCET)
Source: LANCET - April 27, 2018 Category: General Medicine Authors: Andrew N Reynolds Tags: Correspondence Source Type: research
[Correspondence] Associations of fats and carbohydrates with cardiovascular disease and mortality —PURE and simple?
The authors of the Prospective Urban Rural Epidemiological (PURE) study (Nov 4, 2017, p 2050)1 suggest that “removing current restrictions on fat intake, but limiting carbohydrate (when high) might improve health” and that global guidelines should be reconsidered in light of their findings. (Source: LANCET)
Source: LANCET - April 27, 2018 Category: General Medicine Authors: Jim Mann, Joerg Meerpohl, Chizuru Nishida, Rachael McLean, Lisa Te Morenga Tags: Correspondence Source Type: research
[Correspondence] Partnering over the limit: The Global Fund's brewing crisis
We strongly disagree with the recent comments from Peter Sands, the new executive director of The Global Fund to Fight AIDS, Tuberculosis and Malaria.1 In response to serious concerns from civil society,2 researchers,3 journals,4 and national representatives5,6 about The Global Fund's partnership with Heineken, Sands states that “the global health community needs to engage the private sector more rather than less…Because if we really want to achieve the SDGs [Sustainable Development Goals] and build more resilient health systems, we need to partner with the private sector to leverage their resources and their capabilit...
Source: LANCET - April 27, 2018 Category: General Medicine Authors: Robert Marten, Ben Hawkins Tags: Correspondence Source Type: research
[Correspondence] The Global Fund links with Lombard Odier bank
At the World Economic Forum in Davos in January, 2018, Peter Sands —then incoming director of The Global Fund to Fight AIDS, Tuberculosis and Malaria, and former chief executive officer of Standard Chartered Bank—set up deals with Heineken, Lombard Odier, and Unilever. The deal with Heineken, the second largest alcohol brewer in the world, has been severely cri ticised.1 The deal with the Swiss private bank Lombard Odier aims to look at “structures that allow investors to share a proportion of the gains they receive from putting their capital to work”. (Source: LANCET)
Source: LANCET - April 27, 2018 Category: General Medicine Authors: Anthony Costello Tags: Correspondence Source Type: research
