Journal of Neuropathology and Experimental Neurology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Protective Effects of Forskolin on Behavioral Deficits and Neuropathological Changes in a Mouse Model of Cerebral Amyloidosis
The production of amyloid-β peptides in the brains of patients with Alzheimer disease (AD) may contribute to memory loss and impairments in social behavior. Here, an efficient adenylate cyclase activator, forskolin, was orally administered by gavage (100 mg/kg body weight) to 5-month-old transgenic APP/PS1 mice, which serve as an animal model of cerebral amyloidosis. Analyses of nest construction, sociability, and immunohistochemical features were used to determine the effects of forskolin treatment. After a relatively short term of treatment (10 days), forskolin-treated transgenic mice showed restored nest constructi...
Source: Journal of Neuropathology and Experimental Neurology - June 15, 2016 Category: Neurology Authors: Owona, B. A., Zug, C., Schluesener, H. J., Zhang, Z.-Y. Tags: Original Articles Source Type: research

In This Issue
(Source: Journal of Neuropathology and Experimental Neurology)
Source: Journal of Neuropathology and Experimental Neurology - June 15, 2016 Category: Neurology Tags: In This Issue Source Type: research

American Association of Neuropathologists, Inc. Abstracts of the 92nd Annual Meeting June 16-19, 2016 Baltimore, MD
(Source: Journal of Neuropathology and Experimental Neurology)
Source: Journal of Neuropathology and Experimental Neurology - May 24, 2016 Category: Neurology Tags: Abstracts Source Type: research

Autobiography Series: A Celebration of Memorable and Remarkable Teachers
(Source: Journal of Neuropathology and Experimental Neurology)
Source: Journal of Neuropathology and Experimental Neurology - May 24, 2016 Category: Neurology Authors: Gilles, F. Tags: Autobiography Source Type: research

In Memoriam: F. Stephen Vogel, MD
(Source: Journal of Neuropathology and Experimental Neurology)
Source: Journal of Neuropathology and Experimental Neurology - May 24, 2016 Category: Neurology Authors: Burger, P. C., Kinney, H. C. Tags: In Memoriam Source Type: research

Unbiased Stereological Analysis of Reactive Astrogliosis to Estimate Age-Associated Cerebral White Matter Injury
Cerebral white matter injury (WMI) contributes to cognitive dysfunction associated with pathological aging. Because reactive astrocyte-related factors contribute to remyelination failure after WMI, we sought accurate, cost-effective, and reproducible histopathological approaches for quantification of morphometric features of reactive astrogliosis in aged human white matter in patients with vascular brain injury (VBI). We compared 7 distinct approaches to quantify the features of glial fibrillary acidic protein (GFAP)-labeled astrocytes in the prefrontal white matter of brains from patients with VBI (n = 17, mean age 88.8 y...
Source: Journal of Neuropathology and Experimental Neurology - May 24, 2016 Category: Neurology Authors: McNeal, D. W., Brandner, D. D., Gong, X., Postupna, N. O., Montine, T. J., Dirk Keene, C., Back, S. A. Tags: Original Articles Source Type: research

HMGB1 Translocation After Ischemia in the Ovine Fetal Brain
Inflammation contributes to the evolution of hypoxic-ischemic (HI) brain injury. High-mobility group box-1 (HMGB1) is a nuclear protein that is translocated from the nucleus and released after ischemia in adult rodents and thereby initiates inflammatory responses. However, there is very little information regarding the effects of HI on HMGB1 in immature brains. To investigate the effects of HI on HMGB1 in the term-equivalent fetal brain, ovine fetuses at 127 days gestation were studied after 30 minutes of carotid occlusion. Groups were sham-control and ischemia with 48 hours and ischemia with 72 hours of reperfusion. By im...
Source: Journal of Neuropathology and Experimental Neurology - May 24, 2016 Category: Neurology Authors: Zhang, J., Klufas, D., Manalo, K., Adjepong, K., Davidson, , J. O., Wassink, G., Bennet, L., Gunn, A. J., Stopa, E. G., Liu, K., Nishibori, M., Stonestreet, B. S. Tags: Original Articles Source Type: research

Thal Amyloid Stages Do Not Significantly Impact the Correlation Between Neuropathological Change and Cognition in the Alzheimer Disease Continuum
The 2012 neuropathological criteria for the diagnosis of Alzheimer disease (AD) summarize the extent of AD neuropathological change with an ABC score, which is a composite of the Thal stage of amyloid deposition (A), the Braak stage of neurofibrillary tangles (NFTs) (B), and the CERAD neuritic plaque score (C). NFTs and neuritic plaques are well-established contributors to cognitive impairment, but whether the Thal amyloid stage independently predicts antemortem cognition remains unknown. We used the National Alzheimer’s Coordinating Center autopsy data set to build adjacent-categories logit regression models with CD...
Source: Journal of Neuropathology and Experimental Neurology - May 24, 2016 Category: Neurology Authors: Serrano-Pozo, A., Qian, J., Muzikansky, A., Monsell, S. E., Montine, T. J., Frosch, M. P., Betensky, R. A., Hyman, B. T. Tags: Original Articles Source Type: research

Human Traumatic Brain Injury Results in Oligodendrocyte Death and Increases the Number of Oligodendrocyte Progenitor Cells
Oligodendrocyte (OL) death may contribute to white matter pathology, a common cause of network dysfunction and persistent cognitive problems in patients with traumatic brain injury (TBI). Oligodendrocyte progenitor cells (OPCs) persist throughout the adult CNS and may replace dead OLs. OL death and OPCs were analyzed by immunohistochemistry of human brain tissue samples, surgically removed due to life-threatening contusions and/or focal brain swelling at 60.6 ± 75 hours (range 4–192 hours) postinjury in 10 severe TBI patients (age 51.7 ± 18.5 years). Control brain tissue was obtained postmortem from 5 a...
Source: Journal of Neuropathology and Experimental Neurology - May 24, 2016 Category: Neurology Authors: Flygt, J., Gumucio, A., Ingelsson, M., Skoglund, K., Holm, J., Alafuzoff, I., Marklund, N. Tags: Original Articles Source Type: research

Absence of Lymphatic Vessels in PCNSL May Contribute to Confinement of Tumor Cells to the Central Nervous System
Primary central nervous system (CNS) lymphoma (PCNSL) is a mature lymphoma of the diffuse large B-cell lymphoma (DLBCL) type confined to the CNS. Despite cytomorphological similarities between PCNSL and systemic DLBCL, molecular differences between both entities have been identified. The exclusively topographical restriction of PCNSL to the CNS is an unexplained mystery. To address the question of whether the unique lymphatic drainage system of the CNS, which differs from that of other organs, may play a role for this peculiar behavior, we investigated a series of 20 PCNSLs for the presence of lymphatic vessels by immunohi...
Source: Journal of Neuropathology and Experimental Neurology - May 24, 2016 Category: Neurology Authors: Deckert, M., Brunn, A., Montesinos-Rongen, M., Siebert, R. Tags: Brief Report Source Type: research

"New Old Pathologies": AD, PART, and Cerebral Age-Related TDP-43 With Sclerosis (CARTS)
The pathology-based classification of Alzheimer’s disease (AD) and other neurodegenerative diseases is a work in progress that is important for both clinicians and basic scientists. Analyses of large autopsy series, biomarker studies, and genomics analyses have provided important insights about AD and shed light on previously unrecognized conditions, enabling a deeper understanding of neurodegenerative diseases in general. After demonstrating the importance of correct disease classification for AD and primary age-related tauopathy, we emphasize the public health impact of an underappreciated AD "mimic," which has bee...
Source: Journal of Neuropathology and Experimental Neurology - May 24, 2016 Category: Neurology Authors: Nelson, P. T., Trojanowski, J. Q., Abner, E. L., Al-Janabi, O. M., Jicha, G. A., Schmitt, F. A., Smith, C. D., Fardo, D. W., Wang, W.-X., Kryscio, R. J., Neltner, J. H., Kukull, W. A., Cykowski, M. D., Van Eldik, L. J., Ighodaro, E. T. Tags: Review Article Source Type: research

In This Issue
(Source: Journal of Neuropathology and Experimental Neurology)
Source: Journal of Neuropathology and Experimental Neurology - May 24, 2016 Category: Neurology Tags: In This Issue Source Type: research

Appreciation of Reviewers
No abstract available (Source: Journal of Neuropathology and Experimental Neurology)
Source: Journal of Neuropathology and Experimental Neurology - November 18, 2015 Category: Neurology Tags: Appreciation of Reviewers Source Type: research

Greenfield’s Neuropathology, Ninth Edition: 2-Volume Set
No abstract available (Source: Journal of Neuropathology and Experimental Neurology)
Source: Journal of Neuropathology and Experimental Neurology - November 18, 2015 Category: Neurology Tags: Book Review Source Type: research

Margaret Grace Norman, MD, FRCP(C) October 19, 1933–May 17, 2015
No abstract available (Source: Journal of Neuropathology and Experimental Neurology)
Source: Journal of Neuropathology and Experimental Neurology - November 18, 2015 Category: Neurology Tags: In Memoriam Source Type: research