A Candidate Imaging Marker for Early Detection of Charcot Neuroarthropathy
Inflammation-mediated foot osteopenia may play a pivotal role in the etiogenesis, pathogenesis, and therapeutic outcomes in individuals with diabetes mellitus (DM), peripheral neuropathy (PN), and Charcot neuroarthropathy (CN). Our objective was to establish a volumetric quantitative computed tomography –derived foot bone measurement as a candidate prognostic imaging marker to identify individuals with DMPN who were at risk of developing CN. We studied 3 groups: 16 young controls (27 ± 5 years), 20 with DMPN (57 ± 11 years), and 20 with DMPN and CN (55 ± 9 years). (Source: Journal of Clinical Densitometry)
Source: Journal of Clinical Densitometry - June 29, 2017 Category: Radiology Authors: Paul K. Commean, Kirk E. Smith, Charles F. Hildebolt, Kathryn L. Bohnert, David R. Sinacore, Fred W. Prior Tags: Original Article Source Type: research
Assessment of Bone Mineral Density at the Distal Femur and the Proximal Tibia by Dual-Energy X-ray Absorptiometry in IndividualsWith Spinal Cord Injury: Precision of Protocol and Relation to Injury Duration
Spinal cord injury (SCI) is characterized by marked bone loss at the knee, and there is a need for established dual-energy X-ray absorptiometry (DXA) protocols to examine bone mineral density (BMD) at this location to track therapeutic progress and to monitor fracture risk. The purpose of this study was to quantify the precision and reliability of a DXA protocol for BMD assessment at the distal femur and the proximal tibia in individuals with SCI. The protocol was subsequently used to investigate the relationship between BMD and duration of SCI. (Source: Journal of Clinical Densitometry)
Source: Journal of Clinical Densitometry - June 26, 2017 Category: Radiology Authors: Stacey Lobos, Anne Cooke, Gillian Simonett, Chester Ho, Steven K. Boyd, W. Brent Edwards Tags: Original Article Source Type: research
Quantifying Pelvic Periprosthetic Bone Remodeling Using Dual-Energy X-Ray Absorptiometry Region-Free Analysis
The gold standard tool for measuring periprosthetic bone mineral density (BMD) is dual-energy X-ray absorptiometry (DXA). However, resolution of the method is limited due to the aggregation of pixel data into large regions of interest for clinical and statistical analysis. We have previously validated a region-free analysis method (DXA-RFA) for quantitating BMD change at the pixel level around femoral prostheses. Here, we applied the DXA-RFA method to the pelvis, and quantitated its precision in this setting using repeated DXA scans taken on the same day after repositioning in 29 patients after total hip arthroplasty. (Sou...
Source: Journal of Clinical Densitometry - June 24, 2017 Category: Radiology Authors: Andrew M. Parker, Lang Yang, Mohsen Farzi, Jos é M. Pozo, Alejandro F. Frangi, J. Mark Wilkinson Source Type: research
Cortical and Trabecular Bone Analysis of Patients With High Bone Mass From the Barcelona Osteoporosis Cohort Using 3-Dimensional Dual-Energy X-ray Absorptiometry: A Case-Control Study
High bone mass (HBM), a rare phenotype, can be detected by dual-energy X-ray absorptiometry (DXA) scanning. Measurements with peripheral quantitative computed tomography at the tibia have found increased trabecular bone mineral density and changes in cortical bone density and structure, all of which lead to increased bone strength. However, no studies on cortical and trabecular bone have been performed at the femur. The recently developed 3-dimensional (3D)-DXA software algorithm quantifies the trabecular and cortical volumetric bone mineral density (vBMD) and the anatomical distribution of cortical thickness using routine...
Source: Journal of Clinical Densitometry - June 23, 2017 Category: Radiology Authors: Guillermina Orduna, Ludovic Humbert, Roger Fonolla, Jordi Romera, M.Lourdes Cos, Aboro Rial, Xavier Nogu és, Adolfo Diez-Perez, Leonardo Mellibovsky Tags: Original Article Source Type: research
Comparison of Indian Council for Medical Research and Lunar Databases for Categorization of Male Bone Mineral Density
The mainstay of diagnosis of osteoporosis is dual-energy X-ray absorptiometry (DXA) scan measuring areal bone mineral density (BMD) (g/cm2). The aim of the present study was to compare the Indian Council of Medical Research database (ICMRD) and the Lunar ethnic reference database of DXA scans in the diagnosis of osteoporosis in male patients. In this retrospective study, all male patients who underwent a DXA scan were included. The areal BMD (g/cm2) was measured at either the lumbar spine (L1 –L4) or the total hip using the Lunar DXA machine (software version 8.50) manufactured by GE Medical Systems (Shanghai, China). (S...
Source: Journal of Clinical Densitometry - June 19, 2017 Category: Radiology Authors: Surya K. Singh, Vivek H. Patel, Balram Gupta Tags: Original Article Source Type: research
FRAX Score Can Be Used to Avoid Superfluous DXA Scans in Detecting Osteoporosis in Celiac Disease: Accuracy of the FRAX Score in Celiac Patients
This study aimed to evaluate if the FRAX tool can replace or optimize the use of DXA scan in celiac disease (CD). We prospectively enrolled all CD patients aged over 40 yr diagnosed at our third-level unit. At time of CD diagnosis, all patients underwent FRAX score calculation for risk of major osteoporotic and hip fractures and DXA scan (used as gold standard) to assess the accuracy of the FRAX score. (Source: Journal of Clinical Densitometry)
Source: Journal of Clinical Densitometry - June 15, 2017 Category: Radiology Authors: Raffaella Tortora, Nicola Imperatore, Pietro Capone, Nicol ò Gerbino, Matilde Rea, Giovanna Affinito, Nicola Caporaso, Antonio Rispo Tags: Original Article Source Type: research
Structural Parameters of the Proximal Femur by 3-Dimensional Dual-Energy X-ray Absorptiometry Software: Comparison With Quantitative Computed Tomography
Structural parameters of the proximal femur evaluate the strength of the bone and its susceptibility to fracture. These parameters are computed from dual-energy X-ray absorptiometry (DXA) or from quantitative computed tomography (QCT). The 3-dimensional (3D)-DXA software solution provides 3D models of the proximal femur shape and bone density from anteroposterior DXA scans. In this paper, we present and evaluate a new approach to compute structural parameters using 3D-DXA software. A cohort of 60 study subjects (60.9 ± 14.7 yr) with DXA and QCT examinations was collected. (Source: Journal of Clinical Densitometry)
Source: Journal of Clinical Densitometry - June 14, 2017 Category: Radiology Authors: Jordi Clotet, Yves Martelli, Silvana Di Gregorio, Luis Miguel del R ío Barquero, Ludovic Humbert Tags: Original Article Source Type: research
Effects of Teriparatide, Denosumab, or Both on Spine Trabecular Microarchitecture in DATA-Switch: a Randomized Controlled Trial
In postmenopausal women, 2 yr of combined teriparatide and denosumab increases bone mineral density more than either drug alone, and switching from either combination or teriparatide to denosumab for an additional 2 yr further increases bone mineral density. Conversely, switching from denosumab to teriparatide results in transient bone loss. The effects of these interventions on spine microarchitecture are unknown. In the DATA and DATA-Switch studies, 94 postmenopausal osteoporotic women were randomized to receive 24 mo of teriparatide (20 µg daily), denosumab (60 mg every 6 mo), or both. (Source: Journal of ...
Source: Journal of Clinical Densitometry - June 14, 2017 Category: Radiology Authors: Joy N. Tsai, Linda A. Jiang, Hang Lee, Didier Hans, Benjamin Z. Leder Tags: Original Article Source Type: research
