The Risk of Melanoma in Pilots and Cabin Crew
Recently, a meta-analysis reported an increased incidence of melanoma in pilots and cabin crew, which was possibly due to occupational exposures.1 Cabin crews’ exposure to... » (Source: JAMA Oncology)
Source: JAMA Oncology - December 18, 2014 Category: Cancer & Oncology Authors: Martina Sanlorenzo, MD and colleagues Tags: JAMA Dermatology Research Research Letter Source Type: research
Stool DNA Test for Colorectal Cancer Screening
The FDA has approved a stool DNA test to screen average-risk adults aged 50 years or older for colorectal cancer. (Source: JAMA Oncology)
Source: JAMA Oncology - December 18, 2014 Category: Cancer & Oncology Authors: From The Medical Letter on Drugs and Therapeutics Tags: Clinical Review & Education From The Medical Letter on Drugs and Therapeutics JAMA Source Type: research
Intraoperative High-Dose Rate of Radioactive Phosphorus 32 Brachytherapy for Diffuse Recalcitrant Conjunctival Neoplasms
Importance Adjunct treatments for conjunctival malignancies are needed when standard therapy provides limited benefits or fails. Objective To describe the results of patients with diffuse... » (Source: JAMA Oncology)
Source: JAMA Oncology - December 11, 2014 Category: Cancer & Oncology Authors: Brian P. Marr, MD and colleagues Tags: JAMA Ophthalmology Original Investigation Research Source Type: research
A Diffusely Hardened Thyroid Gland and Multiple Neck Lymphadenopathies
A man in his 60s presented with neck swelling. On physical examination a diffusely hardened thyroid gland and multiple neck lymphadenopathies were found. Contrast-enhanced chest... » (Source: JAMA Oncology)
Source: JAMA Oncology - December 11, 2014 Category: Cancer & Oncology Authors: Isidro Machado, MD and colleagues Tags: Clinical Problem Solving Clinical Review & Education JAMA Otolaryngology—Head & Neck Surgery Source Type: research
Fanconi Syndrome Induced by Vemurafenib: A New Renal Adverse Event
Vemurafenib is a BRAF inhibitor approved by the US Food and Drug Administration as treatment for patients with unresectable or metastatic melanoma harboring the BRAF... » (Source: JAMA Oncology)
Source: JAMA Oncology - December 11, 2014 Category: Cancer & Oncology Authors: Daphné Denis, MD and colleagues Tags: Clinical Review & Education JAMA Dermatology Observation Source Type: research
The Role of Adjuvant Therapy in the Management of Head and Neck Merkel Cell Carcinoma
This retrospective review found that adjuvant chemoradiotherapy in head and neck Merkel cell carcinoma may help improve survival in high-risk patients, such as men and... » (Source: JAMA Oncology)
Source: JAMA Oncology - December 4, 2014 Category: Cancer & Oncology Authors: Michelle M. Chen, MD and colleagues Tags: JAMA Otolaryngology—Head & Neck Surgery Original Investigation Research Source Type: research
Improvements in Survival and Disparities for Advanced-Stage Laryngeal Cancer
Importance Laryngeal cancer survival rates have declined over the past 2 decades. Primary surgical therapy may increase survival rates in advanced-stage tumors. Objective To compare... » (Source: JAMA Oncology)
Source: JAMA Oncology - December 4, 2014 Category: Cancer & Oncology Authors: Blake Joseph LeBlanc, MD and colleagues Tags: JAMA Otolaryngology—Head & Neck Surgery Original Investigation Research Source Type: research
Impact of Head and Neck Radiotherapy for Patients With Nasopharyngeal Carcinoma on Sleep-Related Breathing Disorders
Importance Little is known about the relationships between sleep-related breathing disorders (SRBDs) and nasopharyngeal carcinoma (NPC). Objective To clarify the impact of head and neck... » (Source: JAMA Oncology)
Source: JAMA Oncology - December 4, 2014 Category: Cancer & Oncology Authors: Hsin-Ching Lin, MD and colleagues Tags: JAMA Otolaryngology—Head & Neck Surgery Original Investigation Research Source Type: research
Chronic Lymphocytic Leukemia
This evidence-based review reports that chemoimmunotherapy is the standard first-line approach to the treatment of symptomatic chronic lymphocytic leukemia and results in high rates of... » (Source: JAMA Oncology)
Source: JAMA Oncology - December 4, 2014 Category: Cancer & Oncology Authors: Chadi Nabhan, MD and Steven T. Rosen, MD Tags: Clinical Review & Education Featured Clinical Review JAMA Source Type: research
Leukemic Retinopathy
A 17-year-old adolescent boy presented with blurred vision for several weeks. Indirect ophthalmoscopy revealed dilated and tortuous vessels with diffuse retinal infiltrates and intraretinal hemorrhages... » (Source: JAMA Oncology)
Source: JAMA Oncology - December 4, 2014 Category: Cancer & Oncology Authors: Johnathan D. Warminski, MD and Eduardo Uchiyama, MD Tags: Clinical Review & Education JAMA Ophthalmology Ophthalmic Images Source Type: research
MEK Inhibitor–Induced Dusky Erythema: Characteristic Drug Hypersensitivity Manifestation in 3 Patients
Importance MEK inhibitors are being evaluated in clinical trials for treatment of different malignant neoplasms; trametinib dimethyl sulfoxide was approved by the US Food and... » (Source: JAMA Oncology)
Source: JAMA Oncology - December 4, 2014 Category: Cancer & Oncology Authors: Urvi Patel, MD and colleagues Tags: Case Report/Case Series Clinical Review & Education JAMA Dermatology Source Type: research
Higher Frequency of Certain Cancers in LRRK2 G2019S Mutation Carriers With Parkinson Disease
Importance Patients with Parkinson disease (PD) who harbor LRRK2 G2019S mutations may have increased risks of nonskin cancers. However, the results have been inconsistent across studies. Objectives To analyze pooled data from 5 centers to further examine the association between … Continued (Source: JAMA Oncology)
Source: JAMA Oncology - November 20, 2014 Category: Cancer & Oncology Authors: Ilir Agalliu, MD, ScD and colleagues Tags: JAMA Neurology Original Investigation Research Source Type: research
Treatment Strategies in Primary Vitreoretinal Lymphoma
Importance The best treatment option for primary vitreoretinal lymphoma (PVRL) without signs of central nervous system lymphoma (CNSL) involvement determined on magnetic resonance imaging or in cerebrospinal fluid is unknown. Objective To evaluate the outcomes of treatment regimens used for … Continued (Source: JAMA Oncology)
Source: JAMA Oncology - November 20, 2014 Category: Cancer & Oncology Authors: Anjo Riemens, MD, PhD and colleagues Tags: JAMA Ophthalmology Original Investigation Research Source Type: research
Epidemiology and Treatment of Lacrimal Gland Tumors
Importance Primary tumors of the lacrimal gland are rare and are associated with substantial morbidity and mortality. The literature regarding these tumors is limited to case series and case reports. Objective To examine the incidence, treatment, and overall survival (OS) … Continued (Source: JAMA Oncology)
Source: JAMA Oncology - November 13, 2014 Category: Cancer & Oncology Authors: Jon Mallen-St. Clair, MD, PhD and colleagues Tags: JAMA Otolaryngology—Head & Neck Surgery Original Investigation Research Source Type: research
Ocular Adnexal Diffuse Large B-cell Lymphoma
Importance The clinical features of diffuse large B-cell lymphoma (DLBCL) subtype of ocular adnexal lymphoma have not previously been evaluated in a large cohort to our knowledge. Objective To investigate the clinical features of ocular adnexal DLBCL (OA-DLBCL). Design, Setting, … Continued (Source: JAMA Oncology)
Source: JAMA Oncology - November 13, 2014 Category: Cancer & Oncology Authors: Helga D. Munch-Petersen, MD and colleagues Tags: JAMA Ophthalmology Original Investigation Research Source Type: research
