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Parkinsonism in diseases predominantly presenting with dystonia
Publication date: Available online 21 November 2019Source: International Review of NeurobiologyAuthor(s): Alessio Di Fonzo, Giulia Franco, Paolo Barone, Roberto ErroAbstractIf the presence of dystonia is a well-recognized phenomenon in disorders predominantly presenting with parkinsonism, including sporadic Parkinson Disease, the term dystonia-parkinsonism usually refers to rare conditions, often genetic, in which the severity of dystonia usually equates that of parkinsonism. At variance with parkinsonian syndromes with additional dystonia, the conditions reviewed in this chapter have usually their onset in childhood and t...
Source: International Review of Neurobiology - November 22, 2019 Category: Neuroscience Source Type: research

Psychosocial stress and epigenetic aging
Publication date: Available online 20 November 2019Source: International Review of NeurobiologyAuthor(s): Helena Palma-Gudiel, Lourdes Fañanás, Steve Horvath, Anthony S. ZannasAbstractAging is the single most important risk factor for diseases that are currently the leading causes of morbidity and mortality. However, there is considerable inter-individual variability in risk for aging-related disease, and studies suggest that biological age can be influenced by multiple factors, including exposure to psychosocial stress. Among markers of biological age that can be affected by stress, the present article focuses on the so...
Source: International Review of Neurobiology - November 21, 2019 Category: Neuroscience Source Type: research

Chapter Six - From adolescence to late aging: A comprehensive review of social behavior, alcohol, and neuroinflammation across the lifespan
Publication date: 2019Source: International Review of Neurobiology, Volume 148Author(s): Amy E. Perkins, Elena I. Varlinskaya, Terrence DeakAbstractThe passage of time dictates the pace at which humans and other organisms age but falls short of providing a complete portrait of how environmental, lifestyle and underlying biological processes contribute to senescence. Two fundamental features of the human experience that change dramatically across the lifespan include social interactions and, for many, patterns of alcohol consumption. Rodent models show great utility for understanding complex interactions among aging, social...
Source: International Review of Neurobiology - November 13, 2019 Category: Neuroscience Source Type: research

Contributors
Publication date: 2019Source: International Review of Neurobiology, Volume 148Author(s): (Source: International Review of Neurobiology)
Source: International Review of Neurobiology - November 13, 2019 Category: Neuroscience Source Type: research

Preface: Setting the stage for understanding alcohol effects in late aging: A special issue including both human and rodent studies
Publication date: 2019Source: International Review of Neurobiology, Volume 148Author(s): Terrence Deak, Lisa M. SavageAbstractIt is widely recognized that people worldwide are living longer than in previous decades, with formidable projections regarding the expansion of elderly age groups in the decades to come. Older individuals are also sustaining higher levels of alcohol consumption later in life, and binge drinking remains a prevalent pastime in a significant proportion of aged individuals. Older people are more sensitive to neurobehavioral effects of alcohol, and as individuals age, the cumulative impact of lifetime a...
Source: International Review of Neurobiology - November 13, 2019 Category: Neuroscience Source Type: research

Chapter One - Alcohol consumption predicts incidence of depressive episodes across 10 years among older adults in 19 countries
Publication date: 2019Source: International Review of Neurobiology, Volume 148Author(s): Katherine M. Keyes, Kasim Allel, Ursula M. Staudinger, Katherine A. Ornstein, Esteban CalvoAbstractAlcohol consumption is increasing in many countries, and excessive alcohol consumption is particularly increasing among older adults. Excessive alcohol consumption causes morbidity and mortality, especially among older adults, including an increased risk of depressive episodes. We review the mechanisms through which alcohol consumption may affect depression, and argue that the effects of alcohol consumption on depressive episodes among ol...
Source: International Review of Neurobiology - November 13, 2019 Category: Neuroscience Source Type: research

Chapter Two - Clarifying the neurobehavioral sequelae of moderate drinking lifestyles and acute alcohol effects with aging
Publication date: 2019Source: International Review of Neurobiology, Volume 148Author(s): Sara Jo Nixon, Ben LewisAbstractEpidemiological estimates indicate not only an increase in the proportion of older adults, but also an increase in those who continue moderate alcohol consumption. Substantial literatures have attempted to characterize health benefits/risks of moderate drinking lifestyles. Not uncommonly, reports address outcomes in a single outcome, such as cardiovascular function or cognitive decline, rather than providing a broader overview of systems. In this narrative review, retaining focus on neurobiological consi...
Source: International Review of Neurobiology - November 13, 2019 Category: Neuroscience Source Type: research

Chapter Three - I can't drink what I used to: The interaction between ethanol and the aging brain
Publication date: 2019Source: International Review of Neurobiology, Volume 148Author(s): Douglas B. Matthews, Amelia Schneider, Abigail Kastner, Samantha Scaletty, Rachel SzenayAbstractThe population of most countries is increasing and the United Nations predicts that by the year 2050 those over the age of 60 years old will increase from 900 million individuals to approximately 2.1 billion individuals (United Nations, 2015). The increase in the number of older individuals will place a strain on many national health care systems making it important to investigate behaviors in the aged that may negatively impact general heal...
Source: International Review of Neurobiology - November 13, 2019 Category: Neuroscience Source Type: research

Chapter Four - Aging with alcohol-related brain damage: Critical brain circuits associated with cognitive dysfunction
Publication date: 2019Source: International Review of Neurobiology, Volume 148Author(s): Polliana Toledo Nunes, Brian T. Kipp, Nicole L. Reitz, Lisa M. SavageAbstractAlcoholism is associated with brain damage and impaired cognitive functioning. The relative contributions of different etiological factors, such as alcohol, thiamine deficiency and age vulnerability, to the development of alcohol-related neuropathology and cognitive impairment are still poorly understood. One reason for this quandary is that both alcohol toxicity and thiamine deficiency produce brain damage and cognitive problems that can be modulated by age a...
Source: International Review of Neurobiology - November 13, 2019 Category: Neuroscience Source Type: research

Chapter Five - Alcohol drinking exacerbates neural and behavioral pathology in the 3xTg-AD mouse model of Alzheimer's disease
This study was designed to test the hypothesis that nondependent alcohol drinking exacerbates the onset and magnitude of AD-like neural and behavioral pathology. We first evaluated the impact of voluntary 24-h, two-bottle choice home-cage alcohol drinking on the prefrontal cortex and amygdala neuroproteome in C57BL/6J mice and found a striking association between alcohol drinking and AD-like pathology. Bioinformatics identified the AD-associated proteins MAPT (Tau), amyloid beta precursor protein (APP), and presenilin-1 (PSEN-1) as the main modulators of alcohol-sensitive protein networks that included AD-related proteins ...
Source: International Review of Neurobiology - November 13, 2019 Category: Neuroscience Source Type: research

Chapter Seven - A comparison of hippocampal microglial responses in aged and young rodents following dependent and non-dependent binge drinking
Publication date: 2019Source: International Review of Neurobiology, Volume 148Author(s): Isabella R. Grifasi, William Andrew Evans, Annie D. Rexha, Lansana W. Sako, S. Alex MarshallAbstractAlcoholism is a highly visible and prevalent issue in the United States. Although binge-drinking is assumed to be a college-age problem, older adults (ages 65 +) consume binge amounts of alcohol and have alcohol use disorders (AUDs). Moreover, individuals with alcohol dependence in their youth often continue to drink as they age. As such, this study tested the hypothesis that the effects of alcohol on hippocampal microglia are exace...
Source: International Review of Neurobiology - November 13, 2019 Category: Neuroscience Source Type: research

Clarifying the neurobehavioral sequelae of moderate drinking lifestyles and acute alcohol effects with aging
Publication date: Available online 5 November 2019Source: International Review of NeurobiologyAuthor(s): Sara Jo Nixon, Ben LewisAbstractEpidemiological estimates indicate not only an increase in the proportion of older adults, but also an increase in those who continue moderate alcohol consumption. Substantial literatures have attempted to characterize health benefits/risks of moderate drinking lifestyles. Not uncommonly, reports address outcomes in a single outcome, such as cardiovascular function or cognitive decline, rather than providing a broader overview of systems. In this narrative review, retaining focus on neuro...
Source: International Review of Neurobiology - November 6, 2019 Category: Neuroscience Source Type: research

A comparison of hippocampal microglial responses in aged and young rodents following dependent and non-dependent binge drinking
Publication date: Available online 1 November 2019Source: International Review of NeurobiologyAuthor(s): Isabella R. Grifasi, William Andrew Evans, Annie D. Rexha, Lansana W. Sako, S. Alex MarshallAbstractAlcoholism is a highly visible and prevalent issue in the United States. Although binge-drinking is assumed to be a college-age problem, older adults (ages 65 +) consume binge amounts of alcohol and have alcohol use disorders (AUDs). Moreover, individuals with alcohol dependence in their youth often continue to drink as they age. As such, this study tested the hypothesis that the effects of alcohol on hippocampal mic...
Source: International Review of Neurobiology - November 2, 2019 Category: Neuroscience Source Type: research

Alcohol drinking exacerbates neural and behavioral pathology in the 3xTg-AD mouse model of Alzheimer's disease
This study was designed to test the hypothesis that nondependent alcohol drinking exacerbates the onset and magnitude of AD-like neural and behavioral pathology. We first evaluated the impact of voluntary 24-h, two-bottle choice home-cage alcohol drinking on the prefrontal cortex and amygdala neuroproteome in C57BL/6J mice and found a striking association between alcohol drinking and AD-like pathology. Bioinformatics identified the AD-associated proteins MAPT (Tau), amyloid beta precursor protein (APP), and presenilin-1 (PSEN-1) as the main modulators of alcohol-sensitive protein networks that included AD-related proteins ...
Source: International Review of Neurobiology - October 25, 2019 Category: Neuroscience Source Type: research

Aging with alcohol-related brain damage: Critical brain circuits associated with cognitive dysfunction
Publication date: Available online 17 October 2019Source: International Review of NeurobiologyAuthor(s): Polliana Toledo Nunes, Brian T. Kipp, Nicole L. Reitz, Lisa M. SavageAbstractAlcoholism is associated with brain damage and impaired cognitive functioning. The relative contributions of different etiological factors, such as alcohol, thiamine deficiency and age vulnerability, to the development of alcohol-related neuropathology and cognitive impairment are still poorly understood. One reason for this quandary is that both alcohol toxicity and thiamine deficiency produce brain damage and cognitive problems that can be mo...
Source: International Review of Neurobiology - October 18, 2019 Category: Neuroscience Source Type: research