Higher rates of neuropsychiatric adverse events leading to dolutegravir discontinuation in women and older patients
ConclusionsIn this large cohort, the rate of discontinuation of dolutegravir because of neuropsychiatric adverse events was significantly higher than for other INSTIs, at almost 6% within 12 months. Despite the limitations of this retrospective study, the almost three‐fold higher discontinuation rates observed amongst women and older patients underscore the need for further investigation, especially in patient populations usually underrepresented in clinical trials. (Source: HIV Medicine)
Source: HIV Medicine - October 31, 2016 Category: Infectious Diseases Authors: C Hoffmann, T Welz, M Sabranski, M Kolb, E Wolf, H ‐J Stellbrink, C Wyen Tags: Original Research Source Type: research
Alcohol and dietary factors associate with gut integrity and inflammation in HIV ‐infected adults
ConclusionsHIV‐infected adults in a contemporary, high‐resource setting have poor dietary patterns. Alcohol use was associated with worse gut integrity and increased inflammation, while other aspects of diet (fibre, carbohydrates and fat) were not. These data add to growing evidence illustrating the need for a better understanding of the effect of lifestyle factors on comorbidities in HIV‐infected adults. (Source: HIV Medicine)
Source: HIV Medicine - October 31, 2016 Category: Infectious Diseases Authors: AR Webel, A Sattar, NT Funderburg, B Kinley, CT Longenecker, D Labbato, SM Khurshid Alam, GA McComsey Tags: Original Research Source Type: research
Hepatitis C virus (HCV) RNA profiles among chronic HIV/HCV ‐coinfected individuals in ESPRIT; spontaneous HCV RNA clearance observed in nine individuals
ConclusionsHCV RNA levels decreased over time in this population with well‐controlled HIV infection. Spontaneous clearance of HCV RNA was documented in five individuals with IL‐28B genotype CC and four with the CT genotype. (Source: HIV Medicine)
Source: HIV Medicine - October 27, 2016 Category: Infectious Diseases Authors: D Grint, E Tedaldi, L Peters, A Mocroft, B Edlin, S Gallien, H Klinker, C Boesecke, P Kokordelis, JK Rockstroh Tags: Short Communication Source Type: research
Associations between cognitive impairment and patient ‐reported measures of physical/mental functioning in older people living with HIV
ConclusionsThe associations between cognitive impairment and PROMs were weak, possibly because impairment was mild and therefore largely asymptomatic. Further work is needed to elucidate the clinical implications of cognitive impairment in HIV‐disease. (Source: HIV Medicine)
Source: HIV Medicine - October 25, 2016 Category: Infectious Diseases Authors: J Underwood, D De Francesco, FA Post, JH Vera, I Williams, M Boffito, PW Mallon, J Anderson, M Sachikonye, C Sabin, A Winston, Tags: Short Communication Source Type: research
Ageing with HIV: do comorbidities and polymedication drive treatment optimization?
ConclusionsIn ageing HIV‐infected patients, especially those with a long history of HIV infection, comorbidities and coprescriptions are highly prevalent. (Source: HIV Medicine)
Source: HIV Medicine - October 11, 2016 Category: Infectious Diseases Authors: L Cuzin, C Katlama, L Cotte, P Pugliese, A Cheret, C Bernaud, D Rey, I Poizot ‐Martin, C Chirouze, F Bani‐Sadr, A Cabié, Tags: Original Research Source Type: research
Erratum
(Source: HIV Medicine)
Source: HIV Medicine - October 5, 2016 Category: Infectious Diseases Tags: Erratum Source Type: research
A note of thanks to referees for Volume 17, 2016
(Source: HIV Medicine)
Source: HIV Medicine - October 5, 2016 Category: Infectious Diseases Tags: Miscellaneous Source Type: research
Table of Contents
(Source: HIV Medicine)
Source: HIV Medicine - October 5, 2016 Category: Infectious Diseases Tags: Issue Information Source Type: research
Editorial Board
(Source: HIV Medicine)
Source: HIV Medicine - October 5, 2016 Category: Infectious Diseases Tags: Issue Information Source Type: research
An assessment of the relationship between the World Health Organization HIV drug resistance early warning indicators and HIV drug resistance acquisition
ConclusionsSeveral EWIs were associated with and predictive of HIVDR, supporting the WHO EWIs as a component of the HIVDR prevention method in settings where HIVDR testing is not routinely or widely available. (Source: HIV Medicine)
Source: HIV Medicine - October 3, 2016 Category: Infectious Diseases Authors: M St ‐Jean, PR Harrigan, P Sereda, JSG Montaner, VD Lima Tags: Original Research Source Type: research
The clinical value of the controlled attenuation parameter in the follow ‐up of HIV‐infected patients
(Source: HIV Medicine)
Source: HIV Medicine - September 30, 2016 Category: Infectious Diseases Authors: G Ferraioli Tags: Letter to the Editor Source Type: research
Effect of alcohol consumption on all ‐cause and liver‐related mortality among HIV‐infected individuals
ConclusionsAny heavy alcohol consumption was associated with all‐cause mortality among HIV‐infected individuals, while only recent heavy consumption was associated with liver‐related mortality. Because mortality risk among nondrinkers varies substantially by drinking history, current consumption alone is insufficient to assess risk. (Source: HIV Medicine)
Source: HIV Medicine - September 28, 2016 Category: Infectious Diseases Authors: CE Canan, B Lau, ME McCaul, J Keruly, RD Moore, G Chander Tags: Original Research Source Type: research
Human papillomavirus 16 (HPV16) and HPV52 E6 ‐specific immunity in HIV‐infected adults on combination antiretroviral therapy
ConclusionsHPV16 and HPV52 E6‐specific IFN‐γ T‐cell responses, a correlate of protective immunity, were detected more frequently among HIV‐infected patients who achieved optimal immune recovery on cART (26.5%) compared with those with suboptimal recovery (6.3%). (Source: HIV Medicine)
Source: HIV Medicine - September 21, 2016 Category: Infectious Diseases Authors: CY Leng, HC Low, LL Chua, ML Chong, H Sulaiman, I Azwa, JM Roberts, A Kamarulzaman, R Rajasuriar, YL Woo Tags: Original Research Source Type: research
Reference curves for CD4 T ‐cell count response to combination antiretroviral therapy in HIV‐1‐infected treatment‐naïve patients
ConclusionsReference curves aid the evaluation of the immune response early after antiretroviral therapy initiation that leads to viral control. (Source: HIV Medicine)
Source: HIV Medicine - September 14, 2016 Category: Infectious Diseases Authors: V Bouteloup, C Sabin, A Mocroft, L Gras, N Pantazis, V Le Moing, A d'Arminio Monforte, M Mary ‐Krause, B Roca, JM Miro, M Battegay, N Brockmeyer, J Berenguer, P Morlat, N Obel, S De Wit, G Fätkenheuer, R Zangerle, J Ghosn, S Pérez‐Hoyos, M Campbell, Tags: Original Research Source Type: research
Prevalence of and factors associated with depression among people living with HIV in France
ConclusionsThe prevalence of depression varied across the different groups of PLWHIV, with levels much higher than in the general population. Moreover, there was a strong association with socioeconomic status and HIV experience. (Source: HIV Medicine)
Source: HIV Medicine - September 14, 2016 Category: Infectious Diseases Authors: P Feuillet, F Lert, L Tron, C Aubriere, B Spire, R Dray ‐Spira, Tags: Original Research Source Type: research
