Effects of M1 and M4 activation on excitatory synaptic transmission in CA1
This article is protected by copyright. All rights reserved. (Source: Hippocampus)
Source: Hippocampus - April 19, 2017 Category: Neurology Authors: Catherine Thorn, Michael Popiolek, Eda Stark, Jeremy Edgerton Tags: Research Article Source Type: research
Rodent age ‐related impairments in discriminating perceptually similar objects parallel those observed in humans
Abstract
The ability to accurately remember distinct episodes is supported by high‐level sensory discrimination. Performance on mnemonic similarity tasks, which test high‐level discrimination, declines with advancing age in humans and these deficits have been linked to altered activity in hippocampal CA3 and dentate gyrus. Lesion studies in animal models, however, point to the perirhinal cortex as a brain region critical for sensory discriminations that serve memory. Reconciliation of the contributions of different regions within the cortical–hippocampal circuit requires the development of a discrimination paradigm c...
Source: Hippocampus - April 18, 2017 Category: Neurology Authors: Sarah A. Johnson, Sean M. Turner, Lindsay A. Santacroce, Katelyn N. Carty, Leila Shafiq, Jennifer L. Bizon, Andrew P. Maurer, Sara N. Burke Tags: RESEARCH ARTICLE Source Type: research
Issue Information ‐ Editorial Board
(Source: Hippocampus)
Source: Hippocampus - April 17, 2017 Category: Neurology Tags: Issue Information ‐ Editorial Board Source Type: research
Cover Image, Volume 27, Issue 5
This cover image, by M. Haidar et al., is based on the Research Article Relaxin‐3 inputs target hippocampal interneurons and deletion of hilar relaxin‐3 receptors in “floxed‐RXFP3” mice impairs spatial memory, DOI: 10.1002/hipo.22709. (Source: Hippocampus)
Source: Hippocampus - April 17, 2017 Category: Neurology Authors: M. Haidar, G. Gu èvremont, C. Zhang, R.A.D. Bathgate, E. Timofeeva, C.M. Smith, A.L. Gundlach Tags: Cover Image Source Type: research
Involvement of intracellular Zn2+ signaling in LTP at perforant pathway –CA1 pyramidal cell synapse
Abstract
Physiological significance of synaptic Zn2+ signaling was examined at perforant pathway–CA1 pyramidal cell synapses. In vivo long‐term potentiation (LTP) at perforant pathway–CA1 pyramidal cell synapses was induced using a recording electrode attached to a microdialysis probe and the recording region was locally perfused with artificial cerebrospinal fluid (ACSF) via the microdialysis probe. Perforant pathway LTP was not attenuated under perfusion with CaEDTA (10 mM), an extracellular Zn2+ chelator, but attenuated under perfusion with ZnAF‐2DA (50 μM), an intracellular Zn2+ chelator, suggesting that intr...
Source: Hippocampus - April 13, 2017 Category: Neurology Authors: Haruna Tamano, Ryusuke Nishio, Atsushi Takeda Tags: RESEARCH ARTICLE Source Type: research
The interactive effect of demographic and clinical factors on hippocampal volume: A multicohort study on 1958 cognitively normal individuals
In this study, 1958 participants were included (100 AddNeuroMed, 226 ADNI, 155 AIBL, 59 BRC, 295 GENIC, 279 BioFiNDER, 398 PIVUS, and 446 SNAC‐K). ANOVA and random forest were used for testing between‐cohort differences in demographic‐clinical variables. Multiple regression was used to study the influence of demographic‐clinical variables on hippocampal volume. ANCOVA was used to analyze whether between‐cohort differences in demographic‐clinical variables explained between‐cohort differences in hippocampal volume. Age and global brain atrophy were the most important variables in explaining variability in hipp...
Source: Hippocampus - April 10, 2017 Category: Neurology Authors: Daniel Ferreira, Oskar Hansson, Jos é Barroso, Yaiza Molina, Alejandra Machado, Juan Andrés Hernández‐Cabrera, J‐Sebastian Muehlboeck, Erik Stomrud, Katarina Nägga, Olof Lindberg, David Ames, Grégoria Kalpouzos, Laura Fratiglioni, Lars Bäckman, Tags: RESEARCH ARTICLE Source Type: research
Involvement of intracellular Zn2+ signaling in LTP at perforant pathway ‐CA1 pyramidal cell synapse
This article is protected by copyright. All rights reserved. (Source: Hippocampus)
Source: Hippocampus - April 5, 2017 Category: Neurology Authors: Haruna Tamano, Ryusuke Nishio, Atsushi Takeda Tags: Research Article Source Type: research
Whole transcriptome profiling of the human hippocampus suggests an involvement of the KIBRA rs17070145 polymorphism in differential activation of the MAPK signaling pathway
In conclusion, our results suggest that the effect of the WWC1 rs17070145 polymorphism on memory performance and Alzheimer's disease might be due to a differential regulation of the MAPK signaling, a key pathway involved in memory and learning processes. This article is protected by copyright. All rights reserved. (Source: Hippocampus)
Source: Hippocampus - April 1, 2017 Category: Neurology Authors: I.S. Piras, J. Krate, I. Schrauwen, J.J. Corneveaux, G.E. Serrano, L. Sue, T.G. Beach, M.J. Huentelman Tags: Research Article Source Type: research
The medial temporal memory system in Down syndrome: Translating animal models of hippocampal compromise
Abstract
Recent studies have highlighted the dentate gyrus as a region of increased vulnerability in mouse models of Down syndrome (DS). It is unclear to what extent these findings are reflected in the memory profile of people with the condition. We developed a series of novel tasks to probe distinct medial temporal functions in children and young adults with DS, including object, spatial, and serial order memory. Relative to mental age‐matched controls (n = 45), individuals with DS (n = 28) were unimpaired on subtests involving short‐term object or configural recall that was divorced from spatial or temporal c...
Source: Hippocampus - March 27, 2017 Category: Neurology Authors: Caron A.C. Clark, Fabian Fernandez, Stella Sakhon, Goffredina Span ò, Jamie O. Edgin Tags: RESEARCH ARTICLE Source Type: research
Age ‐related impairments in discriminating perceptually similar objects parallel those observed in humans
This article is protected by copyright. All rights reserved. (Source: Hippocampus)
Source: Hippocampus - March 25, 2017 Category: Neurology Authors: Sarah A. Johnson, Sean M. Turner, Lindsay A. Santacroce, Katelyn N. Carty, Leila Shafiq, Jennifer L. Bizon, Andrew P. Maurer, Sara N. Burke Tags: Research Article Source Type: research
Testing the “Boundaries” of Boundary Extension: Anticipatory Scene Representation Across Development and Disorder
This article is protected by copyright. All rights reserved. (Source: Hippocampus)
Source: Hippocampus - March 23, 2017 Category: Neurology Authors: G. Span ò, H. Intraub, J.O. Edgin Tags: Research Article Source Type: research
Aging affects spatial reconstruction more than spatial pattern separation performance even after extended practice
This article is protected by copyright. All rights reserved. (Source: Hippocampus)
Source: Hippocampus - March 21, 2017 Category: Neurology Authors: Rachel Clark, Asli C. Tahan, Patrick D. Watson, Joan Severson, Neal J. Cohen, Michelle Voss Tags: Research Article Source Type: research
Issue Information ‐ Editorial Board
(Source: Hippocampus)
Source: Hippocampus - March 19, 2017 Category: Neurology Tags: Issue Information ‐ Editorial Board Source Type: research
Cover Image, Volume 27, Issue 4
This cover image, by Emmanuel J. Barbeau et al., is based on the Research Article Hippocampus duality: Memory and novelty detection are subserved by distinct mechanisms, DOI: 10.1002/hipo.22699. (Source: Hippocampus)
Source: Hippocampus - March 19, 2017 Category: Neurology Authors: Emmanuel J. Barbeau, Patrick Chauvel, Christopher J.A. Moulin, Jean Regis, Catherine Li égeois‐Chauvel Tags: Cover Image Source Type: research
Damage to right medial temporal structures disrupts the capacity for scene construction —a case study
Abstract
The medial temporal lobes (MTLs) are widely held to support a range of constructive endeavors including remembering the past, envisaging the future, and imagining hypothetical scenarios. While right MTL structures have been ascribed a prominent role in the construction of spatial contexts, lesion evidence to directly test this hypothesis is lacking. To this end, we assessed scene construction performance in two cases, GC and DF, who presented with left‐ and right‐lateralized presentations of semantic dementia, respectively. GC displayed characteristic semantic processing difficulties in the context of marked l...
Source: Hippocampus - March 16, 2017 Category: Neurology Authors: Muireann Irish, Annu Mothakunnel, Nadene Dermody, Nikki ‐Anne Wilson, John R Hodges, Olivier Piguet Tags: RAPID COMMUNICATION Source Type: research
