Aerobic exercise reduces hippocampal ERK and p38 activation and improves memory of middle ‐aged rats
Abstract
Aging is often accompanied by cognitive decline, memory impairment, and an increased susceptibility to neurodegenerative disorders. Although the physiological processes of aging are not fully understood, these age‐related changes have been interpreted by means of various cellular and molecular theories. Among these theories, alterations in the intracellular signaling pathways associated with cell growth, proliferation, and survival have been highlighted. Based on these observations and on recent evidence showing the beneficial effects of exercise on cognitive function in the elderly, we investigated the cell sig...
Source: Hippocampus - June 1, 2017 Category: Neurology Authors: Fabr ízio dos Santos Cardoso, Erivelton Fernandes França, Fernando Tadeu Serra, Angélica Begatti Victorino, Alexandre Aparecido de Almeida, Jansen Fernandes, Francisco Romero Cabral, Daniel Paulino Venancio, Ricardo Mario Arida, Sérgio Gomes da Silva Tags: RESEARCH ARTICLE Source Type: research
Somatostatin Depresses the Excitability of Subicular Bursting Cells: Roles of Inward Rectifier K+ Channels, KCNQ channels and Epac
This article is protected by copyright. All rights reserved. (Source: Hippocampus)
Source: Hippocampus - May 30, 2017 Category: Neurology Authors: Binqi Hu, Nicholas I. Cilz, Saobo Lei Tags: Research Article Source Type: research
Early ‐life stress diminishes the increase in neurogenesis after exercise in adult female mice
This article is protected by copyright. All rights reserved. (Source: Hippocampus)
Source: Hippocampus - May 30, 2017 Category: Neurology Authors: M.R. Abbink, E.F.G. Naninck, P.J. Lucassen, A. Korosi Tags: Rapid Communication Source Type: research
Theta ‐paced flickering between place‐cell maps in the hippocampus: A model based on short‐term synaptic plasticity
This article is protected by copyright. All rights reserved. (Source: Hippocampus)
Source: Hippocampus - May 30, 2017 Category: Neurology Authors: Shirley Mark, Sandro Romani, Karel Jezek, Misha Tsodyks Tags: Research Article Source Type: research
GSK3 activity regulates rhythms in hippocampal clock gene expression and synaptic plasticity
Abstract
Hippocampal rhythms in clock gene expression, enzymatic activity, and long‐term potentiation (LTP) are thought to underlie day–night differences in memory acquisition and recall. Glycogen synthase kinase 3‐beta (GSK3β) is a known regulator of hippocampal function, and inhibitory phosphorylation of GSK3β exhibits region‐specific differences over the light‐dark cycle. Here, we sought to determine whether phosphorylation of both GSK3α and GSK3β isoforms has an endogenous circadian rhythm in specific areas of the hippocampus and whether chronic inhibition or activation alters the molecular clock and hipp...
Source: Hippocampus - May 27, 2017 Category: Neurology Authors: Rachel C. Besing, Courtney O. Rogers, Jodi R. Paul, Lauren M. Hablitz, Russell L. Johnson, Lori L. McMahon, Karen L. Gamble Tags: RESEARCH ARTICLE Source Type: research
Intrinsic cellular and molecular properties of in vivo hippocampal synaptic plasticity are altered in the absence of key synaptic matrix molecules
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Source: Hippocampus - May 17, 2017 Category: Neurology Authors: Stephan Jansen, Christine Gottschling, Andreas Faissner, Denise Manahan ‐Vaughan Tags: Research Article Source Type: research
Issue Information ‐ Editorial Board
(Source: Hippocampus)
Source: Hippocampus - May 17, 2017 Category: Neurology Tags: ISSUE INFORMATION ‐ EDITORIAL BOARD Source Type: research
Cover Image, Volume 27, Issue 6
Cover legend: This cover image, by Lucy Goodman et al., is based on the Research Article N‐terminal SAP97 isoforms differentially regulate synaptic structure and postsynaptic surface pools of AMPA receptors, DOI: 10.1002/hipo.22723. (Source: Hippocampus)
Source: Hippocampus - May 17, 2017 Category: Neurology Authors: Lucy Goodman, David Baddeley, Wojciech Ambroziak, Clarissa L. Waites, Craig C. Garner, Christian Soeller, Johanna M. Montgomery Tags: COVER IMAGE Source Type: research
Aberrant cognitive phenotypes and altered hippocampal BDNF expression related to epigenetic modifications in mice lacking the post ‐synaptic scaffolding protein SHANK1: Implications for autism spectrum disorder
This article is protected by copyright. All rights reserved. (Source: Hippocampus)
Source: Hippocampus - May 1, 2017 Category: Neurology Authors: A. Özge Sungur, Magdalena C.E. Jochner, Hani Harb, Ayşe Kılıç, Holger Garn, Rainer K.W. Schwarting, Markus Wöhr Tags: Research Article Source Type: research
Brain structural connectivity and context ‐dependent extinction memory
Conclusions: Enhanced structural integrity of the cingulum might be related to stronger hippocampal modulation of the dorsal anterior cingulate cortex, a region important for modulating conditioned fear output by excitatory projections to the amygdala. This finding underpins the crucial role of individual differences in the structural integrity of relevant fiber tracts for context‐dependent extinction recall and return of fear after exposure therapy in anxiety disorders. This article is protected by copyright. All rights reserved. (Source: Hippocampus)
Source: Hippocampus - May 1, 2017 Category: Neurology Authors: Andrea Hermann, Rudolf Stark, Carlo R. Blecker, Mohammed R. Milad, Christian J. Merz Tags: Research Article Source Type: research
Running promotes spatial bias independently of adult neurogenesis
(Source: Hippocampus)
Source: Hippocampus - May 1, 2017 Category: Neurology Authors: Jason S. Snyder, Shaina P. Cahill, Paul W. Frankland Tags: Research Article Source Type: research
Complex modulation by stress of the effect of seizures on Long Term Potentiation in mouse hippocampal slices
This article is protected by copyright. All rights reserved. (Source: Hippocampus)
Source: Hippocampus - April 28, 2017 Category: Neurology Authors: Nicola Maggio, Efrat Shavit Stein, Menahem Segal Tags: Research Article Source Type: research
Ventral, but not dorsal, hippocampus inactivation impairs reward memory expression and retrieval in contexts defined by proximal cues
This article is protected by copyright. All rights reserved. (Source: Hippocampus)
Source: Hippocampus - April 27, 2017 Category: Neurology Authors: Sadia Riaz, Anett Schumacher, Seyon Sivagurunathan, Matthijs Van Der Meer, Rutsuko Ito Tags: Research Article Source Type: research
Differential proteome profiling in the hippocampus of amnesic mice
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Source: Hippocampus - April 27, 2017 Category: Neurology Authors: Meghraj Singh Baghel, Mahendra Kumar Thakur Tags: Research Article Source Type: research
Increased 5 ‐hydroxymethylation levels in the hippocampus of rat extinguished from cocaine self‐administration
This study has presented novel findings in the hippocampus of rats that underwent extinction training following cocaine self‐administration. The alterations in the Tet3 gene expression and the level of 5‐hmC may play an important role in extinction learning and the reduction of subsequent cocaine seeking. This article is protected by copyright. All rights reserved. (Source: Hippocampus)
Source: Hippocampus - April 19, 2017 Category: Neurology Authors: Anna Sadakierska ‐Chudy, Małgorzata Frankowska, Karolina Wydra, Joanna Jastrzębska, Joanna Miszkiel, Małgorzata Filip Tags: Research Article Source Type: research
