Hippocampal formation alterations differently contribute to Autobiographic memory deficits in Mild Cognitive Impairment and Alzheimer's Disease
Conclusion: Our findings support the crucial role of CA1, presubiculum and subiculum in episodic memory. The present results implicate that in MCI individuals, semantic and episodic AM deficits are subserved by distinct neuronal systems. This article is protected by copyright. All rights reserved. (Source: Hippocampus)
Source: Hippocampus - March 8, 2017 Category: Neurology Authors: Dusan Hirjak, Robert C. Wolf, Barbara Pfeifer, Ulrich Seidl, Anne K. Thomann, Katharina M. Kubera, Johannes Schr öder, Klaus H. Maier‐Hein, Philipp A. Thomann Tags: Research Article Source Type: research
Reconsolidation ‐induced rescue of a remote fear memory blocked by an early cortical inhibition: Involvement of the anterior cingulate cortex and the mediation by the thalamic nucleus reuniens
ABSTRACT
Systems consolidation is a time‐dependent reorganization process involving neocortical and hippocampal networks underlying memory storage and retrieval. The involvement of the hippocampus during acquisition is well described; however we know much less about the concomitant contribution of cortical activity levels to the formation of stable remote memories. Here, after a reversible pharmacological inhibition of the anterior cingulate cortex (ACC) during the acquisition of a contextual fear conditioning, retrieval of both recent and remote memories were impaired, an effect that was reverted by a single memory reac...
Source: Hippocampus - March 6, 2017 Category: Neurology Authors: Rodrigo O. Sierra, Lizeth K. Pedraza, Querusche K. Zanona, Fabiana Santana, Fl ávia Z. Boos, Ana P. Crestani, Josué Haubrich, Lucas de Oliveira Alvares, Maria Elisa Calcagnotto, Jorge A. Quillfeldt Tags: Research Article Source Type: research
Effect of a hallucinogenic serotonin 5 ‐HT2A receptor agonist on visually guided, hippocampal‐dependent spatial cognition in C57BL/6J mice
ABSTRACT
By acting on serotonin 5‐HT2A receptors (5‐HT2ARs), serotonergic psychedelic drugs induce perceptual and visual hallucinations by increasing neuronal excitability and altering visual‐evoked neuronal responses. The present study was designed to examine whether the perceptual alterations induced by a serotonergic psychedelic drug would affect the integrity of hippocampal‐dependent, visually guided spatial cognition. phenylalkylamine hallucinogen TCB‐2 is a selective agonist of 5‐HT2ARs. Mice received TCB‐2 (1.0 mg kg−1, i.p.), and spatial behaviors and hippocampal electrophysiological responses were...
Source: Hippocampus - March 1, 2017 Category: Neurology Authors: Gongliang Zhang, David Cinalli, Robert W. Stackman Tags: Research Article Source Type: research
Recollection and familiarity in aging individuals: Gaining insight into relationships with medial temporal lobe structural integrity
(Source: Hippocampus)
Source: Hippocampus - February 28, 2017 Category: Neurology Authors: Dorothee Schoemaker, Charlotte Mascret, D. Louis Collins, Elsa Yu, Serge Gauthier, Jens C. Pruessner Tags: Research Article Source Type: research
Damage to right medial temporal structures disrupts the capacity for scene construction – a case study
This article is protected by copyright. All rights reserved. (Source: Hippocampus)
Source: Hippocampus - February 28, 2017 Category: Neurology Authors: Muireann Irish, Annu Mothakunnel, Nadene Dermody, Nikki ‐Anne Wilson, John R. Hodges, Olivier Piguet Tags: Rapid Communication Source Type: research
