Evaluation of Prevalence and Risk Factors of Hepatitis G Virus Infection Among Hemodialysis Patients Referred to Iranian Army Hospitals in Tehran During 2012-2013
Conclusions: Overall, 4.3% of patients had positive results for GBV-C/HGV and all negative for HIV, HCV and HBV. Further studies are needed to elucidate real prevalence, risk factors and characteristics of HGV infection in Iranian hemodialysis patients.,Results: In total, 81 males and 57 females were included. The mean age of patients was 62.16 ± 14.86 years. Six (4.3%) had positive results for GBV-C/HGV by RT-PCR. Except gender (P = 0.045) and duration of dialysis in a week (P < 0.001), other demographic factors revealed no significant difference (P > 0.05). All patients had negative results for HIV Ab, HCV Ab and ...
Source: Hepatitis Monthly - December 31, 2014 Category: Infectious Diseases Source Type: research
Transcatheter Arterial Chemoembolization Therapy for Patients With Unresectable Hepatocellular Carcinoma
Conclusions: We showed that in treatment of patients with unresectable hepatocellular carcinoma, TACE significantly improved the disease and the overall survival rate. Also, we introduce the tumor size, serum ALP level, and number of liver involved segments as prognostic factors of the procedure. Finally, TACE can be recommended as the initial treatment for unresectable HCC patients.,Background: Although transcatheter arterial chemoembolization (TACE) has been widely used as a palliative treatment for unresectable hepatocellular carcinoma (HCC), its actual efficacy and prognostic usefulness have not been clarified in past ...
Source: Hepatitis Monthly - December 27, 2014 Category: Infectious Diseases Source Type: research
Mutations of Basal Core Promoter and Precore Regions in Hepatitis B Virus Genotypes B and C
Conclusions: The mutation ratio difference between genotypes B and C in children was higher than that of adults and several combined mutations were exclusively detected in children with chronic HBV genotype C infection associated with higher viral load.,Objectives: The aim of this study was to assess the mutation profiles of BCP and precore regions in different HBV genotypes in chronically infected children.,Patients and Methods: A cohort of 245 children and 92 adults with chronic HBV infection was included in this study. BCP and precore regions were analyzed by PCR amplification and sequenced.,Results: Ten nucleotide posi...
Source: Hepatitis Monthly - December 27, 2014 Category: Infectious Diseases Source Type: research
HBV Vaccination Status and Response to Hepatitis B Vaccine Among Iranian Dentists, Correlation With Risk Factors and Preventive Measures
Conclusions: Since dental care workers have a high risk of exposure to hepatitis virus, they should be advised to receive hepatitis B vaccine and it should be confirmed if they have acquired immunity to HBV by testing the level of anti-HBs. (Source: Hepatitis Monthly)
Source: Hepatitis Monthly - December 26, 2014 Category: Infectious Diseases Source Type: research
Management of Liver Hemangioma Using Trans-Catheter Arterial Embolization
Conclusions: Our findings indicate that TAE is a safe and efficient procedure for the treatment of liver hemangioma. Further studies with larger sample sizes are required to support therapeutic effects of TAE.,Objectives: To assess the safety, feasibility and efficacy of trans-catheter arterial embolization (TAE) for the treatment of Liver hemangioma (Source: Hepatitis Monthly)
Source: Hepatitis Monthly - December 24, 2014 Category: Infectious Diseases Source Type: research
Opinion Toward Living Liver Donation of Hospital Personnel From Units Related to Organ Donation and Transplantation: A Multicenter Study From Spain and Latin-America
Conclusions: Personnel from donation and transplantation-related units had a favorable attitude toward LLD. This attitude was not affected by psychosocial factors, although it was influenced by factors directly and indirectly related to the donation and transplantation process. (Source: Hepatitis Monthly)
Source: Hepatitis Monthly - December 24, 2014 Category: Infectious Diseases Source Type: research
The Role of Interleukin-6 and Interleukin-8 Gene Polymorphisms in Non-Alcoholic Steatohepatitis
Conclusions: IL6 and IL8 gene polymorphisms have no role in NASH pathogenesis and liver fibrosis process, but presence of the A/A genotype in the IL8 gene is associated with disease progression.,Patients and Methods: Consecutive patients with biopsy proven NASH and age- and gender-matched healthy individuals with normal liver function tests and normal ultrasonography were enrolled in the study. Histopathological findings were recorded according to nonalcoholic fatty liver disease activity score (NAS). Patients were classified according to fibrosis scores as fibrosis score < 2 (mild fibrosis group) and fibrosis score ≥...
Source: Hepatitis Monthly - December 23, 2014 Category: Infectious Diseases Source Type: research
Prevalence of Hepatitis C Virus Genotypes in Iranian Patients: A Systematic Review and Meta-Analysis
Conclusions: The most frequent subtypes of HCV in Iran were 1a, 3a and 1b, respectively. This frequency differed in various provinces of Iran and fluctuated with time. It is important to determine the distribution of HCV genotypes in different geographical areas and its trend with time for epidemiological and patients’ management purposes.,Objectives: The aim of this study was to estimate the overall prevalence and trend of HCV genotypes or subtypes in Iran,Data Sources: A literature review was done for papers reporting HCV genotypes in Iranian patients in PubMed, Magiran, IranMedex, Scientific Information Databank, and ...
Source: Hepatitis Monthly - December 23, 2014 Category: Infectious Diseases Source Type: research
Association of Periodontal Diseases and Liver Fibrosis in Patients With HCV and/or HBV infection
Conclusions: Periodontitis might be associated with progression of viral liver disease; hence, controlling oral disease is essential for the prevention and management of liver fibrosis.,Objectives: The aim of this study was to evaluate the association between periodontitis and progression of liver diseases in patients with HCV and/or HBV infection.,Patients and Methods: In this retrospective study, 351 patients with HCV- and/or HBV-related liver diseases underwent screening for periodontal disease using the Salivaster® salivary occult blood test from February 2010 to June 2014. Furthermore, we examined the prevalence of f...
Source: Hepatitis Monthly - December 19, 2014 Category: Infectious Diseases Source Type: research
Association of Upregulated HMGB1 and c-IAP2 Proteins With Hepatocellular Carcinoma Development and Progression
Conclusions: Expression of HMGB1 and c-IAP2 proteins was associated with HCC development and progression, and the expression of HMGB1 and c-IAP2 proteins in HCC were significantly associated with each other. Additionally, these proteins may show promise as biomarkers to predict HCC progression.,Background: Hepatocellular carcinoma (HCC) is one of the most important health problems in China.,Objectives: This study analyzed expression of high-mobility group protein B1 (HMGB1) and inhibitor of apoptosis protein-2 (c-IAP2) proteins in HCC compared to paired para-tumor tissue samples to assess the association with HCC pathogene...
Source: Hepatitis Monthly - December 14, 2014 Category: Infectious Diseases Source Type: research
Distribution of Hepatitis B Virus Genotypes in Azerbaijani Patients With Chronic Hepatitis B Infection
Conclusions: The main and frequent HBV genotype among Azerbaijani patients with chronic hepatitis B virus infection was genotype D followed by genotype A.,Results: The mean age of patients was 35.9 ± 11.7 years (19-66). Of 103 patients, 72 (69.9%) were male. In the present study, the predominant HBV genotype was D (93.2%) followed by genotype A (5.8%) and concurrent infection with A and D genotypes (0.97%).,Patients and Methods: One hundred and three patients with chronic HBV infection, referred to hospitals related to Iran University of Medical Sciences and Tehran Hepatitis Center from August 2011 to July 2014, were enro...
Source: Hepatitis Monthly - December 8, 2014 Category: Infectious Diseases Source Type: research
S Gene Mutants Occurrence Among Hepatitis B Carriers in Malaysia
Conclusions: Association with sex, genotype and clinical symptoms revealed that the pre-S1 ORF deletion occurred in 40% , 40%,and 20% of genotypes B,C, and D respectively, and 80% of the female population, of which all but one were diagnosed with chronic hepatitis B. Additionally, several mutations were found in the BCP region with the following incidence rate; C1653 T (8.6%), A1752 G (10.8%),1762 AGG--TGA 1764 (26.9%), C1766T(2.2%),T1768 A (10.8%), C1858 T (64.5%), G1896 A (25.8%).,Results: A total of 76 HBV full genome and 17 partial genome sequences were obtained from the 93 sequenced sera samples Genotyping of the full...
Source: Hepatitis Monthly - November 29, 2014 Category: Infectious Diseases Source Type: research
Enhanced-Transient Expression of Hepatitis C Virus Core Protein in Nicotiana tabacum, a Protein With Potential Clinical Applications
Conclusions: By employment of gene optimization strategies, use of viral-based vectors and suppression of plant-derived gene silencing effect, efficient transient expression of HCVcp in tobacco with proper antigenic properties could be possible.,Background: Hepatitis C virus (HCV) is major cause of liver cirrhosis in humans. HCV capsid (core) protein (HCVcp) is a highly demanded antigen for various diagnostic, immunization and pathogenesis studies. Plants are considered as an expression system for producing safe and inexpensive biopharmaceutical proteins. Although invention of transgenic (stable) tobacco plants expressing ...
Source: Hepatitis Monthly - November 23, 2014 Category: Infectious Diseases Source Type: research
Epidemiology of Hepatitis B in the Reproductive-Age Female Farmworkers of Southeastern Turkey
Conclusions: The monitoring of at-risk groups like seasonal migratory farmworkers is necessary to strengthen the healthcare service provided to this population.,Objectives: This study aimed to determine the prevalence of HBV infection and associated risk factors in the reproductive-age female farmworker.,Materials and Methods: This cross-sectional study was conducted between January and April 2013 in southeastern region (SAR) of Turkey. A community-based representative agricultural sample (n = 705) from the agricultural areas of nine provinces of SAR was randomly determined by clustering method using Epi Info software. Que...
Source: Hepatitis Monthly - November 22, 2014 Category: Infectious Diseases Source Type: research
Risk Factors of Hepatitis C Virus Infection in Drug Users From Eleven Methadone Maintenance Treatment Clinics in Xi’an, China
Conclusions: The major risk factor of HCV infection was injection drug use. The patient’s awareness of his or her HCV status had a minor effect in reduction of illicit drug use and improvement in MMT retention. Therefore, adequate counseling is necessary for drug users in MMT clinics in Xi’an.,Background: Hepatitis C virus (HCV) infection rates in drug users vary among different regions of China. Drug users who are unaware of their HCV serostatus tend to engage in more risky behaviors.,Objectives: This prospective study aimed to assess risk factors of HCV infection in drug users among 11 methadone maintenance treatment...
Source: Hepatitis Monthly - November 22, 2014 Category: Infectious Diseases Source Type: research
