An Index to Predict Ribavirin-Induced Anemia in Asian Patients With Chronic Genotype 1 Hepatitis C
Conclusions: In patients with CHC G1 and receiving combination therapy, ITPA SNP-based index was an accurate and practical solution for prediction of severe anemia.,Background: Single-nucleotide polymorphisms (SNP) in the inosine triphosphate pyrophosphatase (ITPA) gene correlate with ribavirin (RBV)-induced anemia in patients with chronic hepatitis C (CHC) receiving combination therapy. Managing anemia is an early priority in the treatment process.,Objectives: The aim was to develop a predictive index based on ITPA SNP status to identify CHC patients at risk of anemia.,Patients and Methods: A total of 418 eligible East As...
Source: Hepatitis Monthly - March 19, 2015 Category: Infectious Diseases Source Type: research
Dystrophic-Anagen Effluvium Occurring During Pegylated Interferon-α-2a/Ribavirin Therapy
Conclusions: Although some cases of alopecia areata (AA) and telogen effluvium (TE) were reported in literature, no case of DAE associated with PEG-INF-α-2a /RBV combination therapy was reported previously. (Source: Hepatitis Monthly)
Source: Hepatitis Monthly - March 19, 2015 Category: Infectious Diseases Source Type: research
Optimization of Three Dimensional Culturing of the HepG2 Cell Line in Fibrin Scaffold
Conclusions: Our approach provided easy handle method using inexpensive materials like human plasma instead of purified fibrinogen to fabricate fibrin scaffold.,Results: The optimal concentrations for fibrin scaffold fabrication were achieved by adding 0.15 mol CaCl2 (50 µL) and 1 × 105 cells to 1:4 of plasma/RPMI 1640 ratio (500 µL with 2.3 mm thickness per well).,Materials and Methods: In a one-stage experimental design, Box-Behnken design strategy was performed by Minitab 15 software (version 15, Minitab. State College, PA) with three factors at three levels (low, medium and high) and 27 runs for identification of th...
Source: Hepatitis Monthly - March 19, 2015 Category: Infectious Diseases Source Type: research
Sequencing and Phylogenetic Study of Partial NS3 Gene of Iranian GB Virus C/Hepatitis G Virus (HGV) Originated From Hemodialysis Patients in Tehran
Conclusions: Overall, results of present study were consistent with the data reported earlier base on 5’ NTR in Iranian isolates and revealed genotype IR2 is major genotype in Iranian HGV-positive patient. It means there are higher similarities between Iranian and Europe-USA in HGV NS3 gene.,Results: Nucleotide BLAST results emphasized that most similar sequences to Ir NS3 sequences were those from Europe (Spain, Germany, and the United Kingdom) and the United states and IR sequences were located with five leaves in a branch. In addition, homology of Ir sequences showed96.4% (between IR1 and IR2), 94.9% identity (between...
Source: Hepatitis Monthly - March 4, 2015 Category: Infectious Diseases Source Type: research
Association of Mutations in the Basal Core Promoter and Pre-core Regions of the Hepatitis B Viral Genome and Longitudinal Changes in HBV Level in HBeAg Negative Individuals: Results From a Cohort Study in Northern Iran
Conclusions: In this population with chronic HBeAg negative hepatitis B, an association was observed between the G1896A mutation in the Pre-core region of HBV and subsequent level of HBV DNA seven years later, which indicated that mutations in this region of HBV genome may contribute to disease progression in these patients and play an important role in HBV natural course of disease. (Source: Hepatitis Monthly)
Source: Hepatitis Monthly - February 20, 2015 Category: Infectious Diseases Source Type: research
Oxidative Stress Response in Patients Infected by Diverse Hepatitis C Virus Genotypes
Conclusions: More serious disease in HCV genetic subtype 1a/1b might be associated with more severe oxidative stress. Milder damage in subtypes 4, 2a/c, 2b and 3a could be related to lower oxidative response, respectively. A combination of antiviral and antioxidative therapies may enhance the overall response rate of patients with HCV infection, especially with more destructive genotypes. (Source: Hepatitis Monthly)
Source: Hepatitis Monthly - February 20, 2015 Category: Infectious Diseases Source Type: research
Telaprevir Experience From Turkey
Conclusions: Although more frequent and severe adverse effects, telaprevir has been promising for patients with treatment-experienced hepatitis C. (Source: Hepatitis Monthly)
Source: Hepatitis Monthly - February 17, 2015 Category: Infectious Diseases Source Type: research
Hepatoprotective Effect of 17β-Estradiol as Antioxidant Modulators Against Stress Damage
Conclusions: Estrogen seemed to be not very effective to prevent eccentric exercise-induced liver damage. (Source: Hepatitis Monthly)
Source: Hepatitis Monthly - February 8, 2015 Category: Infectious Diseases Source Type: research
The Prevalence of Hepatitis C Virus Infection and Its Related Risk Factors Among the Rural Population of Fars Province, Southern Iran
Conclusions: Our reported rate of HCV seropositivity is similar to the previous Iranian reports. However, future evaluations should be focused on the Polymerase Chain Reaction method for the detection of HCV and determining and evaluating of other related risk factors. Moreover, more attention should be paid to blood donors as a reservoir population of HCV. (Source: Hepatitis Monthly)
Source: Hepatitis Monthly - February 5, 2015 Category: Infectious Diseases Source Type: research
Serum NX-DCP as a New Noninvasive Model to Predict Significant Liver Fibrosis in Chronic Hepatitis C
Conclusions: NX-DCP correlated positively with fibrosis stage and could discriminate well between HCV-related patients with or without significant fibrosis. Moreover, NX-DCP had a similar predictive ability to the abovementioned models, and thereby could be a new noninvasive prediction tool for fibrosis.,Results: Increase in serum NX-DCP was significantly related to increase in fibrosis stage (P = 0.006). Moreover, NX-DCP was a multivariate factor associated with the presence of significant fibrosis F 3-4 (median 21 of F0-2 group vs. median 22 of F3-4 group with P = 0.002). The AUC of NX-DCP showed no significant differenc...
Source: Hepatitis Monthly - February 5, 2015 Category: Infectious Diseases Source Type: research
The Effect of Berberis Vulgaris Extract on Transaminase Activities in Non-Alcoholic Fatty Liver Disease
Conclusions: Considering the significant decrease in the liver enzymes, triglycerides and cholesterol after using berberis vulgaris extract, further studies with larger sample sizes will identify the accurate dose as well as duration of consumption for this extract, to recommend in the treatment of patients with NAFLD.,Results: In the case group, the mean serum levels of alanine transaminase (ALT) and aspartate transaminase (AST) decreased from 49 to 27.48 and 48.22 to 29.8 u/L, respectively, which was statistically significant compared to the control group (P < 0.001, P < 0.001). In the control group, the mean of AL...
Source: Hepatitis Monthly - February 4, 2015 Category: Infectious Diseases Source Type: research
Association Between Platelet Count as a Noninvasive Marker and Ultrasonographic Grading in Patients With Nonalcoholic Fatty Liver Disease
Conclusions: Platelet count in nonalcoholic fatty liver disease can serve as a clue to the severity of disease, but it cannot be considered as a sole test to follow up patients. (Source: Hepatitis Monthly)
Source: Hepatitis Monthly - January 17, 2015 Category: Infectious Diseases Source Type: research
Efficacy of Prolonged Treatment With Pegylated Interferon (Peg-IFN) and Ribavirin in Thalassemic Patients With Hepatitis C Who Relapsed After Previous Peg-IFN-Based Therapy
Conclusions: The present study suggests that thalassemic patients with chronic hepatitis C genotype 1 infection who did not achieve SVR after a course of therapy with Peg-IFN and RBV may benefit from being retreated with a 72-week regimen. (Source: Hepatitis Monthly)
Source: Hepatitis Monthly - January 12, 2015 Category: Infectious Diseases Source Type: research
Development of Magnetic Capture Hybridization and Quantitative Polymerase Chain Reaction for Hepatitis B Virus Covalently Closed Circular DNA
Conclusions: The novel MCH-qPCR method has good sensitivity and specificity. It could meet the requirement of clinical routine detection. (Source: Hepatitis Monthly)
Source: Hepatitis Monthly - January 4, 2015 Category: Infectious Diseases Source Type: research
Efficacy of 24-Week Pegylated Interferon Alpha and Ribavirin Combination Therapy in Highly Selected Patients Infected With Hepatitis C Virus Genotype 1
Conclusions: The current study confirmed that the efficacy of a 24-week regimen of Peg-IFN-alfa-2a plus RBV was similar to the 48-week treatment in the patients infected with HCV genotype 1, and low baseline HCV RNA level who achieved RVR. Response guided therapy can be efficient and cost-effective among the selected HCV genotype 1-infected patients. (Source: Hepatitis Monthly)
Source: Hepatitis Monthly - December 31, 2014 Category: Infectious Diseases Source Type: research
