Genomics, Proteomics and Bioinformatics 
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Publication date: April 2018Source: Genomics, Proteomics & Bioinformatics, Volume 16, Issue 2Author(s): Jiaqi Gu, Ming Wang, Yang Yang, Ding Qiu, Yiqun Zhang, Jinbiao Ma, Yu Zhou, Gregory J. Hannon, Yang YuAbstractProtein–RNA interaction networks are essential to understand gene regulation control. Identifying binding sites of RNA-binding proteins (RBPs) by the UV-crosslinking and immunoprecipitation (CLIP) represents one of the most powerful methods to map protein–RNA interactions in vivo. However, the traditional CLIP protocol is technically challenging, which requires radioactive labeling and suffers from material l...
Source: Genomics, Proteomics and Bioinformatics - July 5, 2018 Category: Bioinformatics Source Type: research
Tet2 Regulates Osteoclast Differentiation by Interacting with Runx1 and Maintaining Genomic 5-Hydroxymethylcytosine (5hmC)
Publication date: Available online 13 June 2018Source: Genomics, Proteomics & BioinformaticsAuthor(s): Yajing Chu, Zhigang Zhao, David Wayne Sant, Ganqian Zhu, Sarah M. Greenblatt, Lin Liu, Jinhuan Wang, Zeng Cao, Jeanette Cheng Tho, Shi Chen, Xiaochen Liu, Peng Zhang, Jaroslaw P. Maciejewski, Stephen Nimer, Gaofeng Wang, Weiping Yuan, Feng-Chun Yang, Mingjiang XuAbstractAs a dioxygenase, Ten-Eleven Translocation 2 (TET2) catalyzes subsequent steps of 5-methylcytosine (5mC) oxidation. TET2 plays a critical role in the self-renewal, proliferation, and differentiation of hematopoietic stem cells, but its impact on mature hem...
Source: Genomics, Proteomics and Bioinformatics - July 5, 2018 Category: Bioinformatics Source Type: research
Reversible RNA Modification N1-methyladenosine (m1A) in mRNA and tRNA
Publication date: Available online 14 June 2018Source: Genomics, Proteomics & BioinformaticsAuthor(s): Chi Zhang, Guifang JiaAbstractMore than 100 modifications have been found in RNA. Analogous to epigenetic DNA methylation, epitranscriptomic modifications can be written, read, and erased by a complex network of proteins. Apart from N6-methyladenosine (m6A), N1-methyladenosine (m1A) has been found as a reversible modification in tRNA and mRNA. m1A occurs at positions 9, 14, and 58 of tRNA, with m1A58 being critical for tRNA stability. Other than the hundreds of m1A sites in mRNA and long non-coding RNA transcripts, transc...
Source: Genomics, Proteomics and Bioinformatics - July 5, 2018 Category: Bioinformatics Source Type: research
Tet2 Regulates Osteoclast Differentiation by Interacting with Runx1 and Maintaining Genomic 5-Hydroxymethylcytosine (5hmC)
Publication date: Available online 13 June 2018 Source:Genomics, Proteomics & Bioinformatics Author(s): Yajing Chu, Zhigang Zhao, David Wayne Sant, Ganqian Zhu, Sarah M. Greenblatt, Lin Liu, Jinhuan Wang, Zeng Cao, Jeanette Cheng Tho, Shi Chen, Xiaochen Liu, Peng Zhang, Jaroslaw P. Maciejewski, Stephen Nimer, Gaofeng Wang, Weiping Yuan, Feng-Chun Yang, Mingjiang Xu As a dioxygenase, Ten-eleven translocation 2 (TET2) catalyzes subsequent steps of 5-methylcytosine (5mC) oxidation. Tet2 plays a critical role in the self-renewal, proliferation, and differentiation of hematopoietic stem cells, but it...
Source: Genomics, Proteomics and Bioinformatics - June 14, 2018 Category: Bioinformatics Source Type: research
Reversible RNA Modification N1-methyladenosine (m1A) in mRNA and tRNA
Publication date: Available online 14 June 2018 Source:Genomics, Proteomics & Bioinformatics Author(s): Chi Zhang, Guifang Jia More than 100 modifications have been found in RNA. Analogous to epigenetic DNA methylation, epitranscriptomic modifications can be written, read, and erased by a complex network of proteins. Apart from N 6-methyladenosine (m6A), N 1-methyladenosine (m1A) has been found as a reversible modification in tRNA and mRNA. m1A occurs at positions 9, 14, and 58 of tRNA, with m1A58 being critical for tRNA stability. Other than the hundreds of m1A sites in mRNA and long non-coding RNA transcripts...
Source: Genomics, Proteomics and Bioinformatics - June 14, 2018 Category: Bioinformatics Source Type: research
