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Structural and functional characterization of salmon STAT1, STAT2 and IRF9 homologs sheds light on interferon signaling in teleosts
Publication date: Available online 7 October 2014 Source:FEBS Open Bio Author(s): Mehrdad Sobhkhez , Astrid Skjesol , Ernst Thomassen , Linn Greiner Tollersrud , Dimitar B. Iliev , Baojian Sun , Børre Robertsen , Jorunn B. Jørgensen Mammalian IRF9 and STAT2, together with STAT1, form the ISGF3 transcription factor complex, which is critical for type I interferon (IFN)-induced signaling, while IFNγ stimulation is mediated by homodimeric STAT1 protein. Teleost fish are known to possess most JAK and STAT family members, however, description of their functional activity in lower vertebrates is still scarce. In t...
Source: FEBS Open Bio - October 12, 2014 Category: Molecular Biology Source Type: research