Clinical Implementation of Pharmacogenetic Testing in a Hospital of the Spanish National Health System: Strategy and Experience Over 3 Years
Abstract
In 2014, we established a pharmacogenetics unit with the intention of facilitating the integration of pharmacogenetic testing into clinical practice. This unit was centered around two main ideas: i) individualization of clinical recommendations, and ii) preemptive genotyping in risk populations. Our unit is based on the design and validation of a single nucleotide polymorphism (SNP) microarray, which has allowed testing of 180 SNPs associated with drug response (PharmArray), and clinical consultation regarding the results. Herein, we report our experience in integrating pharmacogenetic testing into our hospital an...
Source: Clinical and Translational Science - November 28, 2017 Category: Biomedical Science Authors: Alberto M. Borobia, Irene Dapia, Hoi Y. Tong, Pedro Arias, Mario Mu ñoz, Jair Tenorio, Rafael Hernández, Irene García García, Gema Gordo, Elena Ramírez, Jesús Frías, Pablo Lapunzina, Antonio J. Carcas Tags: ARTICLE Source Type: research
Reverse Translation in Advancing Pharmacotherapy in Pediatric Rheumatology: A Logical Approach in Rare Diseases with Limited Resources
(Source: Clinical and Translational Science)
Source: Clinical and Translational Science - November 28, 2017 Category: Biomedical Science Authors: Mara L. Becker, Ryan S. Funk Tags: COMMENTARY Source Type: research
Inflammatory and Physiological Consequences of Debridement of Fibrous Tissue after Volumetric Muscle Loss Injury
Abstract
Volumetric muscle loss (VML) injuries present chronic loss of muscle fibers followed by expansive fibrotic tissue deposition. Regenerative medicine therapies are under development to promote regeneration. However, mitigation of the expansive fibrous tissue is required for integration with the remaining muscle. Using a porcine VML model, delayed debridement of injury fibrosis was performed 3 months post‐VML and observed for an additional 4 weeks. A second group underwent the initial VML and was observed for 4 weeks, allowing comparison of initial fibrosis formation and debrided groups. The following salient obser...
Source: Clinical and Translational Science - November 28, 2017 Category: Biomedical Science Authors: Benjamin T. Corona, Jessica C. Rivera, Sarah M. Greising Tags: ARTICLE Source Type: research
Model ‐Based Meta‐Analysis for Multiple Myeloma: A Quantitative Drug‐Independent Framework for Efficient Decisions in Oncology Drug Development
Clinical and Translational Science,Volume 11, Issue 2, Page 218-225, March 2018. (Source: Clinical and Translational Science)
Source: Clinical and Translational Science - November 23, 2017 Category: Biomedical Science Source Type: research
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Clinical and Translational Science, Ahead of Print. (Source: Clinical and Translational Science)
Source: Clinical and Translational Science - November 23, 2017 Category: Biomedical Science Source Type: research
Model ‐Based Meta‐Analysis for Multiple Myeloma: A Quantitative Drug‐Independent Framework for Efficient Decisions in Oncology Drug Development
Abstract
The failure rate for phase III trials in oncology is high; quantitative predictive approaches are needed. We developed a model‐based meta‐analysis (MBMA) framework to predict progression‐free survival (PFS) from overall response rates (ORR) in relapsed/refractory multiple myeloma (RRMM), using data from seven phase III trials. A Bayesian analysis was used to predict the probability of technical success (PTS) for achieving desired phase III PFS targets based on phase II ORR data. The model demonstrated a strongly correlated (R2 = 0.84) linear relationship between ORR and median PFS. As a representative applic...
Source: Clinical and Translational Science - November 23, 2017 Category: Biomedical Science Authors: Zhaoyang Teng, Neeraj Gupta, Zhaowei Hua, Guohui Liu, Vivek Samnotra, Karthik Venkatakrishnan, Richard Labotka Tags: ARTICLE Source Type: research
Navigating the Clinical Translation of Medical Devices: The Case of Radiofrequency Ablation
(Source: Clinical and Translational Science)
Source: Clinical and Translational Science - November 18, 2017 Category: Biomedical Science Authors: Abdel Armaiz Flores, Marianna L. Oppenheimer Velez, Scott M. Thompson, Anthony J. Windebank, Alexandra J. Greenberg ‐Worisek Tags: COMMENTARY Source Type: research
Genome ‐wide and Phenome‐wide Approaches to Understand Variable Drug Actions in Electronic Health Records
Clinical and Translational Science, Page 112-122, March 2018. (Source: Clinical and Translational Science)
Source: Clinical and Translational Science - November 17, 2017 Category: Biomedical Science Source Type: research
Genome ‐wide and Phenome‐wide Approaches to Understand Variable Drug Actions in Electronic Health Records
Clinical and Translational Science,Volume 11, Issue 2, Page 112-122, March 2018. (Source: Clinical and Translational Science)
Source: Clinical and Translational Science - November 17, 2017 Category: Biomedical Science Source Type: research
Genome ‐wide and Phenome‐wide Approaches to Understand Variable Drug Actions in Electronic Health Records
Clinical and Translational Science, Page 112-122, March 2018. (Source: Clinical and Translational Science)
Source: Clinical and Translational Science - November 17, 2017 Category: Biomedical Science Source Type: research
Genome ‐wide and Phenome‐wide Approaches to Understand Variable Drug Actions in Electronic Health Records
Clinical and Translational Science,Volume 11, Issue 2, Page 112-122, March 2018. (Source: Clinical and Translational Science)
Source: Clinical and Translational Science - November 17, 2017 Category: Biomedical Science Source Type: research
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Clinical and Translational Science, Ahead of Print. (Source: Clinical and Translational Science)
Source: Clinical and Translational Science - November 17, 2017 Category: Biomedical Science Source Type: research
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Clinical and Translational Science, March 2018. (Source: Clinical and Translational Science)
Source: Clinical and Translational Science - November 17, 2017 Category: Biomedical Science Source Type: research
