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Clinical and Translational Science, Ahead of Print. (Source: Clinical and Translational Science)
Source: Clinical and Translational Science - December 19, 2017 Category: Biomedical Science Source Type: research
Reverse Translation of US Food and Drug Administration Reviews of Oncology New Molecular Entities Approved in 2011 –2017: Lessons Learned for Anticancer Drug Development
(Source: Clinical and Translational Science)
Source: Clinical and Translational Science - December 19, 2017 Category: Biomedical Science Authors: Stephanie Faucette, Santosh Wagh, Ashit Trivedi, Karthik Venkatakrishnan, Neeraj Gupta Tags: REVIEW Source Type: research
S ‐Nitrosohemoglobin Levels and Patient Outcome After Transfusion During Pediatric Bypass Surgery
Clinical and Translational Science,Volume 11, Issue 2, Page 237-243, March 2018. (Source: Clinical and Translational Science)
Source: Clinical and Translational Science - December 12, 2017 Category: Biomedical Science Source Type: research
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Clinical and Translational Science, Ahead of Print. (Source: Clinical and Translational Science)
Source: Clinical and Translational Science - December 12, 2017 Category: Biomedical Science Source Type: research
S ‐Nitrosohemoglobin Levels and Patient Outcome After Transfusion During Pediatric Bypass Surgery
Abstract
Banked blood exhibits impairments in nitric oxide (NO)‐based oxygen delivery capability, reflected in rapid depletion of S‐nitrosohemoglobin (SNO‐Hb). We hypothesized that transfusion of even freshly‐stored blood used in pediatric heart surgery would reduce SNO‐Hb levels and worsen outcome. In a retrospective review (n = 29), the percent of estimated blood volume (% eBV) replaced by transfusion directly correlated with ventilator time and inversely correlated with kidney function; similar results were obtained in a prospective arm (n = 20). In addition, an inverse association was identified between SNO...
Source: Clinical and Translational Science - December 12, 2017 Category: Biomedical Science Authors: Faisal Matto, Peter C. Kouretas, Richard Smith, Jacob Ostrowsky, Anthony J. Cina, Douglas T. Hess, Jonathan S. Stamler, James D. Reynolds Tags: ARTICLE Source Type: research
Pharmacogenetic Analysis of the Model ‐Based Pharmacokinetics of Five Anti‐HIV Drugs: How Does This Influence the Effect of Aging?
Clinical and Translational Science,Volume 11, Issue 2, Page 226-236, March 2018. (Source: Clinical and Translational Science)
Source: Clinical and Translational Science - December 3, 2017 Category: Biomedical Science Source Type: research
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Clinical and Translational Science, Ahead of Print. (Source: Clinical and Translational Science)
Source: Clinical and Translational Science - December 3, 2017 Category: Biomedical Science Source Type: research
Pharmacogenetic Analysis of the Model ‐Based Pharmacokinetics of Five Anti‐HIV Drugs: How Does This Influence the Effect of Aging?
Abstract
Analysis of aging and pharmacogenetics (PGx) on antiretroviral pharmacokinetics (PKs) could inform precision dosing for older human HIV‐infected patients. Seventy‐four participants receiving either atazanavir/ritonavir (ATV/RTV) or efavirenz (EFV) with tenofovir/emtricitabine (TFV/FTC) provided PK and PGx information. Aging‐PGx‐PK association and interaction analyses were conducted using one‐way analysis of variance (ANOVA), multiple linear regression, and Random Forest ensemble methods. Our analyses associated unbound ATV disposition with multidrug resistance protein (MRP)4, RTV with P‐glycoprotein (P...
Source: Clinical and Translational Science - December 3, 2017 Category: Biomedical Science Authors: Jingxian Chen, Farida S. Akhtari, Michael J. Wagner, Oscar Suzuki, Tim Wiltshire, Alison A. Motsinger ‐Reif, Julie B. Dumond Tags: ARTICLE Source Type: research
Diagnostic Testing for Zika: Observing Rapid Translation During a Public Health Emergency
Clinical and Translational Science,Volume 11, Issue 2, Page 103-105, March 2018. (Source: Clinical and Translational Science)
Source: Clinical and Translational Science - December 1, 2017 Category: Biomedical Science Source Type: research
Translational Development of Microbiome ‐Based Therapeutics: Kinetics of E. coli Nissle and Engineered Strains in Humans and Nonhuman Primates
Clinical and Translational Science,Volume 11, Issue 2, Page 200-207, March 2018. (Source: Clinical and Translational Science)
Source: Clinical and Translational Science - December 1, 2017 Category: Biomedical Science Source Type: research
Diagnostic Testing for Zika: Observing Rapid Translation During a Public Health Emergency
Clinical and Translational Science,Volume 11, Issue 2, Page 103-105, March 2018. (Source: Clinical and Translational Science)
Source: Clinical and Translational Science - December 1, 2017 Category: Biomedical Science Source Type: research
Translational Development of Microbiome ‐Based Therapeutics: Kinetics of E. coli Nissle and Engineered Strains in Humans and Nonhuman Primates
Clinical and Translational Science,Volume 11, Issue 2, Page 200-207, March 2018. (Source: Clinical and Translational Science)
Source: Clinical and Translational Science - December 1, 2017 Category: Biomedical Science Source Type: research
