Implementation of Standardized Clinical Processes for TPMT Testing in a Diverse Multidisciplinary Population: Challenges and Lessons Learned
Clinical and Translational Science,Volume 11, Issue 2, Page 175-181, March 2018. (Source: Clinical and Translational Science)
Source: Clinical and Translational Science - January 19, 2018 Category: Biomedical Science Source Type: research
A Preclinical Population Pharmacokinetic Model for Anti ‐CD20/CD3 T‐Cell‐Dependent Bispecific Antibodies
Clinical and Translational Science, EarlyView. (Source: Clinical and Translational Science)
Source: Clinical and Translational Science - January 19, 2018 Category: Biomedical Science Source Type: research
Implementation of Standardized Clinical Processes for TPMT Testing in a Diverse Multidisciplinary Population: Challenges and Lessons Learned
Clinical and Translational Science,Volume 11, Issue 2, Page 175-181, March 2018. (Source: Clinical and Translational Science)
Source: Clinical and Translational Science - January 19, 2018 Category: Biomedical Science Source Type: research
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Clinical and Translational Science, Ahead of Print. (Source: Clinical and Translational Science)
Source: Clinical and Translational Science - January 19, 2018 Category: Biomedical Science Source Type: research
Implementation of Standardized Clinical Processes for TPMT Testing in a Diverse Multidisciplinary Population: Challenges and Lessons Learned
Abstract
Although thiopurine S‐methyltransferase (TPMT) genotyping to guide thiopurine dosing is common in the pediatric cancer population, limited data exist on TPMT testing implementation in diverse, multidisciplinary settings. We established TPMT testing (genotype and enzyme) with clinical decision support, provider/patient education, and pharmacist consultations in a tertiary medical center and collected data over 3 years. During this time, 834 patients underwent 873 TPMT tests (147 (17%) genotype, 726 (83%) enzyme). TPMT tests were most commonly ordered for gastroenterology, rheumatology, dermatology, and hematology...
Source: Clinical and Translational Science - January 19, 2018 Category: Biomedical Science Authors: Kristin W. Weitzel, D. Max Smith, Amanda R. Elsey, Benjamin Q. Duong, Benjamin Burkley, Michael Clare ‐Salzler, Yan Gong, Tara A. Higgins, Benjamin Kong, Taimour Langaee, Caitrin W. McDonough, Benjamin J. Staley, Teresa T. Vo, Dyson T. Wake, Larisa H. C Tags: ARTICLE Source Type: research
Erratum to “Phase I Studies of Acebilustat: Pharmacokinetics, Pharmacodynamics, Food Effect, and CYP3A Induction”
(Source: Clinical and Translational Science)
Source: Clinical and Translational Science - January 9, 2018 Category: Biomedical Science Tags: ERRATUM Source Type: research
Issue Information
(Source: Clinical and Translational Science)
Source: Clinical and Translational Science - January 9, 2018 Category: Biomedical Science Tags: ISSUE INFORMATION Source Type: research
Developing Pharmacogenomic Reports: Insights from Patients and Clinicians
Clinical and Translational Science, EarlyView. (Source: Clinical and Translational Science)
Source: Clinical and Translational Science - January 8, 2018 Category: Biomedical Science Source Type: research
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Clinical and Translational Science, Ahead of Print. (Source: Clinical and Translational Science)
Source: Clinical and Translational Science - January 8, 2018 Category: Biomedical Science Source Type: research
Developing Pharmacogenomic Reports: Insights from Patients and Clinicians
Abstract
Increasingly, for a variety of indications, patients have their genomes sequenced and actionable results returned. A subset of returned results is pharmacogenomic (PGx) variants involved in the metabolism or action of medications. Although the impact of these variants on health is well‐documented, little research exists on how to communicate these findings to patients and clinicians. We conducted semistructured interviews with end users to understand how best to communicate PGx results. Overall, patients and clinicians had similar opinions regarding report content, delivery, and application. Unique concerns spec...
Source: Clinical and Translational Science - January 8, 2018 Category: Biomedical Science Authors: Laney K. Jones, Alanna Kulchak Rahm, Michael R. Gionfriddo, Janet L. Williams, Audrey L. Fan, Rebecca A. Pulk, Eric A. Wright, Marc S. Williams Tags: ARTICLE Source Type: research
Big Data Toolsets to Pharmacometrics: Application of Machine Learning for Time ‐to‐Event Analysis
In conclusion, ML‐based methods provide a powerful tool for time‐to‐event analysis, with a built‐in capacity for high‐dimensional data and better performance when the predictor variables assume nonlinear relationships in the hazard function. (Source: Clinical and Translational Science)
Source: Clinical and Translational Science - January 1, 2018 Category: Biomedical Science Authors: Xiajing Gong, Meng Hu, Liang Zhao Tags: ARTICLE Source Type: research
2017 Reviewer Acknowledgment
(Source: Clinical and Translational Science)
Source: Clinical and Translational Science - January 1, 2018 Category: Biomedical Science Tags: REVIEWER ACKNOWLEDGMENT Source Type: research
Initial Clinical Experience with AZD5718, a Novel Once Daily Oral 5 ‐Lipoxygenase Activating Protein Inhibitor
Abstract
We evaluated safety, tolerability, pharmacokinetics, and pharmacodynamics of AZD5718, a novel 5‐lipooxygenase activating protein (FLAP) inhibitor, in a randomized, single‐blind, placebo‐controlled, first‐in‐human (FIH) study consisting of single and multiple ascending dosing (SAD and MAD) for 10 days in healthy subjects. Target engagement was measured by ex vivo calcium ionophore stimulated leukotriene B (LTB4) production in whole blood and endogenous leukotriene E (LTE4) in urine. No clinically relevant safety and tolerability findings were observed. The AZD5718 was rapidly absorbed and plasma concentra...
Source: Clinical and Translational Science - January 1, 2018 Category: Biomedical Science Authors: Hans Ericsson, Karin Nelander, Maria Lagerstrom ‐Fermer, Clare Balendran, Maria Bhat, Ligia Chialda, Li‐Ming Gan, Maria Heijer, Magnus Kjaer, John Lambert, Eva‐Lotte Lindstedt, Gun‐Britt Forsberg, Carl Whatling, Stanko Skrtic Tags: ARTICLE Source Type: research
