Clinical and Experimental Immunology Clinical and Experimental Immunology RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Soluble TAM receptor tyrosine kinases in rheumatoid arthritis: correlation with disease activity and bone destruction
Clinical&Experimental Immunology,Volume 192, Issue 1, Page 95-103, April 2018. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - November 17, 2017 Category: Allergy & Immunology Source Type: research

---
Clinical&Experimental Immunology,Volume 192, Issue 1, Page 95-103, April 2018. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - November 17, 2017 Category: Allergy & Immunology Source Type: research

Genetic immunization with mouse thyrotrophin hormone receptor plasmid breaks self ‐tolerance for a murine model of autoimmune thyroid disease and Graves' orbitopathy
In this study, we report on the development of a bona fide murine model of autoimmune Graves' disease induced with homologous mouse TSHR A‐subunit plasmid. Autoimmune thyroid disease in the self‐antigen model was accompanied by GO and characterized by histopathology of hyperplastic glands with large thyroid follicular cells. Examination of orbital tissues showed significant inflammation in extra‐ocular muscle with accumulation of T cells and macrophages together with substantial deposition of adipose tissue. Notably, increased levels of brown adipose tissue were present in the orbital tissue of animals undergoing exp...
Source: Clinical and Experimental Immunology - November 17, 2017 Category: Allergy & Immunology Authors: A. Schl üter, M. Horstmann, S. Diaz‐Cano, S. Plöhn, K. Stähr, S. Mattheis, M. Oeverhaus, S. Lang, U. Flögel, U. Berchner‐Pfannschmidt, A. Eckstein, J. P. Banga Tags: Original Article Source Type: research

Immune Checkpoint Inhibitors: New strategies to checkmate cancer
This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - November 15, 2017 Category: Allergy & Immunology Authors: Ruairi A. M. Wilson, T. R. Jeffry Evans, Alasdair R. Fraser, Robert J. B. Nibbs Tags: Review Source Type: research

TXNDC5 Contributes to Rheumatoid Arthritis by Down ‐regulating IGFBP1 Expression
This study investigated whether TXNDC5 contributes to RA via the insulin signaling pathway. In the study, RA synovial fibroblast‐like cells (RASFs) transfected with an anti‐TXNDC5 small interfering RNA (siRNA) were analyzed with an Insulin Signaling Pathway RT2 Profiler PCR Array and an Insulin Resistance RT2 Profiler PCR Array. The PCR arrays detected significantly increased expression of insulin‐like growth factor binding protein 1 (IGFBP1) in RASFs with suppressed TXNDC5 expression. The result was verified using real‐time PCR and western blot analyses. Significantly elevated IGFBP1 expression and decreased IL‐...
Source: Clinical and Experimental Immunology - November 13, 2017 Category: Allergy & Immunology Authors: Jian Li, Bing Xu, Changsun Wu, Xinfeng Yan, Lei Zhang, Xiaotian Chang Tags: Original Article Source Type: research

TXNDC5 contributes to rheumatoid arthritis by down ‐regulating IGFBP1 expression
Clinical&Experimental Immunology,Volume 192, Issue 1, Page 82-94, April 2018. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - November 13, 2017 Category: Allergy & Immunology Source Type: research

---
Clinical&Experimental Immunology,Volume 192, Issue 1, Page 82-94, April 2018. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - November 13, 2017 Category: Allergy & Immunology Source Type: research

Preoperative methylprednisolone increases plasma Pentraxin 3 early after total knee arthroplasty: a randomized, double ‐blind, placebo‐controlled trial
In conclusion, preoperative MP 125 mg increased circulating PTX3 and reduced the general inflammatory response (CRP) early after TKA, but did not affect other complement markers. This study evaluated the inflammatory marker Pentraxin‐3 and other complement marker changes after preoperative intravenous administration of methylprednisolone (MP) early after total knee arthroplasty. MP resulted in an increase in circulating Pentraxin‐3 compared to saline from baseline to 24 hours postoperatively, while MP reduced the systemic inflammatory response (CRP) 24 and 48 hours postoperatively. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - November 9, 2017 Category: Allergy & Immunology Authors: V. Lindberg ‐Larsen, H. Kehlet, K. Pilely, J. Bagger, M. L. Rovsing, P. Garred Tags: Original Article Source Type: research

Co ‐inhibitory profile and cytotoxicity of CD57+PD‐1– T cells in end‐stage renal disease patients
In conclusion, alloantigen‐activated CD4+CD57+PD‐1– T cells exhibited a less proliferative but more cytotoxic profile than their CD57– counterparts. Their cytotoxic capacity can be inhibited partly by belatacept and was not associated with development of rejection after kidney transplantation. We show that CD4+CD57+PD‐1‐ T cells show a more senescent, but a potentially more cytotoxic profile than their CD57‐ counterpart. This cytotoxic potential can be partly inhibited by belatacept in both groups and this inhibition was not associated with the development of rejection after kidney transplantation. (Source: ...
Source: Clinical and Experimental Immunology - November 9, 2017 Category: Allergy & Immunology Authors: R. Kraaijeveld, G. N. de Graav, M. Dieterich, N. H. R. Litjens, D. A. Hesselink, C. C. Baan Tags: Original Article Source Type: research

Bronchiectasis and deteriorating lung function in agammaglobulinaemia despite immunoglobulin replacement therapy
Summary Immunoglobulin replacement therapy enhances survival and reduces infection risk in patients with agammaglobulinaemia. We hypothesized that despite regular immunoglobulin therapy, some patients will experience ongoing respiratory infections and develop progressive bronchiectasis with deteriorating lung function. One hundred and thirty‐nine (70%) of 199 patients aged 1–80 years from nine cities in the United Kingdom with agammaglobulinaemia currently listed on the UK Primary Immune Deficiency (UKPID) registry were recruited into this retrospective case study and their clinical and laboratory features analysed; 94...
Source: Clinical and Experimental Immunology - November 3, 2017 Category: Allergy & Immunology Authors: A. Stubbs, C. Bangs, B. Shillitoe, J. D. Edgar, S. O. Burns, M. Thomas, H. Alachkar, M. Buckland, E. McDermott, G. Arumugakani, M. S. Jolles, R. Herriot, P. D. Arkwright Tags: Original Article Source Type: research

Whole genome microarray expression analysis in blood identifies pathways linked to signs and symptoms of a patient with hypercalprotectinaemia and hyperzincaemia
Summary A child, 2 years with the ‘hypercalprotectinaemia with hyperzincaemia’ clinical syndrome, presented with atypical symptoms and signs, notably persistent fever of approximately 38°C, thrombocythaemia of > 700 × 109/l and a predominance of persistent intestinal symptoms. In an effort to find a cure by identifying the dysregulated pathways we analysed whole‐genome mRNA expression by the Affymetrix HG U133 Plus 2·0 array in blood on three occasions 3–5 months apart. Major up‐regulation was demonstrated for the Janus kinase/signal transducer and activators of transcription (JAK/STAT) pathway including...
Source: Clinical and Experimental Immunology - November 3, 2017 Category: Allergy & Immunology Authors: H. S. Isaksson, S. A. Farkas, P. M üller, D. Gustafsson, T. K. Nilsson Tags: Original Article Source Type: research

In ‐vitro effect of pembrolizumab on different T regulatory cell subsets
This study suggests that pembrolizumab does not affect Treg or change their phenotype or function but rather blocks signaling via PD‐1/PD‐L1 axis in activated T cells. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - November 3, 2017 Category: Allergy & Immunology Authors: S. M. Toor, A. S. Syed Khaja, I. Alkurd, E. Elkord Tags: Original Article Source Type: research

Intestinal anti ‐transglutaminase2 IgA deposits in children at risk for coeliac disease: data from the Prevent CD study
This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - November 1, 2017 Category: Allergy & Immunology Authors: Melissa Borrelli, Mariantonia Maglio, Ilma R Korponay ‐Szabó, Viktória Vass, M. Luisa Mearin, Caroline Meijer, Hagit Niv‐Drori, Carmen Ribes‐Koninckx, María Roca, Raanan Shamir, Riccardo Troncone, Renata Auricchio Tags: Original Article Source Type: research

Activation of plasmacytoid dendritic cells by apoptotic particles — mechanism for the loss of immunologic tolerance in Sjögren's syndrome
This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - November 1, 2017 Category: Allergy & Immunology Authors: Mari Ainola, Pauliina Porola, Yuya Takakubo, Beata Przybyla, Vesa ‐Petteri Kouri, Tuomas Aleksi Tolvanen, Arno Hänninen, Dan Christian Nordström Tags: Original Article Source Type: research

Clinical and functional significance of STEAP4 ‐splice variant in CD14+ monocytes in patients with rheumatoid arthritis
This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - October 28, 2017 Category: Allergy & Immunology Authors: Hiroshi Ebe, Isao Matsumoto, Hoshimi Kawaguchi, Izumi Kurata, Yuki Tanaka, Asuka Inoue, Yuya Kondo, Hiroto Tsuboi, Takayuki Sumida Tags: Original Article Source Type: research