Co ‐inhibitory profile and cytotoxicity of CD57+PD‐1– T cells in end‐stage renal disease patients

In conclusion, alloantigen‐activated CD4+CD57+PD‐1– T cells exhibited a less proliferative but more cytotoxic profile than their CD57– counterparts. Their cytotoxic capacity can be inhibited partly by belatacept and was not associated with development of rejection after kidney transplantation. We show that CD4+CD57+PD‐1‐ T cells show a more senescent, but a potentially more cytotoxic profile than their CD57‐ counterpart. This cytotoxic potential can be partly inhibited by belatacept in both groups and this inhibition was not associated with the development of rejection after kidney transplantation.
Source: Clinical and Experimental Immunology - Category: Allergy & Immunology Authors: Tags: Original Article Source Type: research