Clinical and Experimental Immunology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Th17, synchronically increased with Tregs and Bregs, promoted by tumour cells via cell ‐contact in primary hepatic carcinoma
Clinical&Experimental Immunology, EarlyView. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - January 26, 2018 Category: Allergy & Immunology Source Type: research

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Clinical&Experimental Immunology, Ahead of Print. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - January 26, 2018 Category: Allergy & Immunology Source Type: research

Th17, synchronically increased with Tregs and Bregs, promoted by tumour cells via cell ‐contact in primary hepatic carcinoma
In this study, numerous experiments were undertaken to elucidate the interaction of Th17 and Treg/Breg cells involved in PHC. Our work demonstrated that an increased Th17 was detected in the peripheral circulation and in tumour tissues in PHC patients. In addition, increases in peripheral blood Th17 corresponded with tumour–node–metastasis (TNM) stage progression. Also, further studies indicated that Th17 cells were promoted by tumour cells in the PHC tumour microenvironment through both contact‐dependent and ‐independent mechanisms, but cell‐contact played the major important role in promoting the production and...
Source: Clinical and Experimental Immunology - January 26, 2018 Category: Allergy & Immunology Authors: W. Wang, Z. Wang, Y. Qin, G. Tang, G. Cai, Y. Liu, J. Zhang, P. Zhang, Q. Shen, L. Shen, W. Yu Tags: Original Article Source Type: research

Activated leukocyte cell adhesion molecule (ALCAM/CD166) regulates T cell responses in a murine model of food allergy
This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - January 24, 2018 Category: Allergy & Immunology Authors: Yun Seon Kim, Mi Na Kim, Kyung Eun Lee, Jung Yeon Hong, Mi Seon Oh, Soo Yeon Kim, Kyung Won Kim, Myung Hyun Sohn Tags: Original Article Source Type: research

The adjuvant system AS01 up ‐regulates neutrophil CD14 expression and neutrophil‐associated antigen transport in the local lymphatic network
This study reports an increase in CD14 expression on lymphatic neutrophils following vaccination with AS01 that directly correlates with increased neutrophil‐associated antigen uptake capacity. Significant and transient increases in CD14 expression on systemic neutrophils were also observed following primary and boost vaccination with HBsAg‐AS01, however was not observed following additional encounter with HBsAg‐alone or HBsAg‐alum. This study reveals a potential role for local and systemic neutrophils in the in vivo immune response induced by the adjuvant AS01. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - January 23, 2018 Category: Allergy & Immunology Authors: M. R. Neeland, W. Shi, C. Collignon, E. N. T. Meeusen, A. M. Didierlaurent, M. J. de Veer Tags: Original Article Source Type: research

Bronchiolitis obliterans syndrome is associated with increased p ‐glycoprotein expression and loss of glucocorticoid receptor from steroid resistant pro‐inflammatory CD8+T cells
This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - January 21, 2018 Category: Allergy & Immunology Authors: Greg Hodge, Sandra Hodge, Phan Tien Nguyen, Aeneas Yeo, Parama Sarkar, Arash Badiei, Holmes ‐Liew CL, Paul N. Reynolds, Mark Holmes Tags: Original Article Source Type: research

Immunomodulatory activity of glycodelin: implications in allograft rejection
Clinical&Experimental Immunology, EarlyView. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - January 18, 2018 Category: Allergy & Immunology Source Type: research

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Clinical&Experimental Immunology, Ahead of Print. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - January 18, 2018 Category: Allergy & Immunology Source Type: research

Differential serum cytokine profile in patients with systemic lupus erythematosus and posterior reversible encephalopathy syndrome
Clinical&Experimental Immunology, EarlyView. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - January 16, 2018 Category: Allergy & Immunology Source Type: research

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Clinical&Experimental Immunology, Ahead of Print. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - January 16, 2018 Category: Allergy & Immunology Source Type: research

Genetics of immune ‐mediated inflammatory diseases
This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - January 12, 2018 Category: Allergy & Immunology Authors: Trixy David, Stephanie Ling, Anne Barton Tags: Review Source Type: research

LAIR ‐1 shedding from human fibroblast‐like synoviocytes in rheumatoid arthritis following TNF‐α stimulation
This study examined the expression of the inhibitory receptor, leukocyte‐associated immunoglobulin (Ig)‐like receptor‐1 (LAIR‐1) in fibroblast‐like synoviocytes (FLS) in rheumatoid arthritis (RA) patients to investigate its potential role in the modulation of inflammatory cytokines, metalloproteinases (MMPs), and invasiveness of synoviocytes. LAIR‐1 expression in synovial tissues from RA patients, osteoarthritis patients, and healthy donors was analyzed by immunohistochemistry. The membrane‐bound form (mLAIR‐1) was detected by flow cytometry. Factors involved in inflammation and MMP activity in FLS were ana...
Source: Clinical and Experimental Immunology - January 12, 2018 Category: Allergy & Immunology Authors: Yuan Zhang, Song Wang, Haiying Dong, Xin Yi, Jinxue zhang, Xueqin Liu, Ran Zhuang, Yong Ding Tags: Original Article Source Type: research

Repository corticotrophin injection exerts direct acute effects on human B cell gene expression distinct from the actions of glucocorticoids
Summary Repository corticotrophin injection (RCI, H.P Acthar® gel) has been approved for use in the management of multiple autoimmune and inflammatory diseases for more than a half‐century, but its mechanism of action is not well understood. We used RNA‐Seq methods to define RCI‐regulated mRNAs in cultured human B cells under conditions of activation by interleukin (IL)‐4 and CD40 ligand. Following IL‐4/CD40L activation and RCI treatment we found up‐regulation of 115 unique mRNA transcripts and down‐regulation of 80 unique mRNAs. The effect on these RNA levels was dose‐dependent for RCI and was distinct fr...
Source: Clinical and Experimental Immunology - January 12, 2018 Category: Allergy & Immunology Authors: A. L. Benko, C. A. McAloose, P. M. Becker, D. Wright, T. Sunyer, Y. I. Kawasawa, N. J. Olsen, W. J. Kovacs Tags: Original Article Source Type: research

Characterization of ectopic lymphoid structures in different types of acute renal allograft rejection
Conclusion: ELSs with an activated phenotype are predominantly found in aTCMRI where T cells co‐localize with B cells. These findings suggest a direct pathway of B cell allo‐activation at the graft site during T cell mediated rejection. This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - January 10, 2018 Category: Allergy & Immunology Authors: Kitty de Leur, Marian C. Clahsen ‐van Groningen, Thierry P.P. van den Bosch, Gretchen N. de Graav, Dennis A. Hesselink, Janneke N. Samsom, Carla C. Baan, Karin Boer Tags: Original Article Source Type: research

Issue Information
(Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - January 8, 2018 Category: Allergy & Immunology Tags: Issue Information Source Type: research