The adjuvant system AS01 up ‐regulates neutrophil CD14 expression and neutrophil‐associated antigen transport in the local lymphatic network

This study reports an increase in CD14 expression on lymphatic neutrophils following vaccination with AS01 that directly correlates with increased neutrophil‐associated antigen uptake capacity. Significant and transient increases in CD14 expression on systemic neutrophils were also observed following primary and boost vaccination with HBsAg‐AS01, however was not observed following additional encounter with HBsAg‐alone or HBsAg‐alum. This study reveals a potential role for local and systemic neutrophils in the in vivo immune response induced by the adjuvant AS01.
Source: Clinical and Experimental Immunology - Category: Allergy & Immunology Authors: Tags: Original Article Source Type: research