Advancing the management of Obstructive Airways Diseases through Translational Research
This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - February 7, 2018 Category: Allergy & Immunology Authors: Celeste Porsbjerg, Asger Sverrild, Katherine J Baines, Andrew Searles, Steven Maltby, Paul S. Foster, Chris Brightling, Peter G. Gibson Tags: Invited Review Source Type: research
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Clinical&Experimental Allergy, Ahead of Print. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - February 2, 2018 Category: Allergy & Immunology Source Type: research
Distinction between rhinovirus ‐induced acute asthma and asthma‐augmented influenza infection
Conclusions and Clinical relevanceIn children with respiratory symptoms and/or fever, RV but not IFV is associated with wheeze and an asthma‐like presentation. In those with an asthma history, IFV causes more generalised and severe disease that may be better described as ‘asthma‐augmented influenza’ rather than an ‘asthma attack’. Differences in the acute conditions caused by these viruses should be considered in the design of epidemiological studies.This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - February 1, 2018 Category: Allergy & Immunology Authors: George V. Guibas, Maria Tsolia, Ioannis Christodoulou, Fotini Stripeli, Zoi Sakkou, Nikolaos G. Papadopoulos Tags: Original Article ‐Clinical Mechanisms in Allergic Disease Source Type: research
Eosinophil ‐derived exosomes contribute to asthma remodelling by activating structural lung cells
Conclusions and Clinical RelevanceEosinophil‐derived exosomes from asthmatic patients participate actively in the development of the pathological features of asthma via structural lung cells.This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - February 1, 2018 Category: Allergy & Immunology Authors: Jos é A. Cañas, Beatriz Sastre, José M. Rodrigo‐Muñoz, Mar Fernández‐Nieto, Pilar Barranco, Santiago Quirce, Joaquín Sastre, Victoria del Pozo Tags: Original Article ‐Basic Mechanisms in Allergic Disease Source Type: research
Is yoghurt an acceptable alternative to raw milk for reducing eczema and allergy in infancy?
This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - February 1, 2018 Category: Allergy & Immunology Authors: Julian Crane, Christine Barthow, Edwin A Mitchell, Thorsten V Stanley, Gordon Purdie, Judy Rowden, Janice Kang, Fiona Hood, Phillipa Barnes, Penny Fitzharris, Robyn Maude, Peter Stone, Rinki Murphy, Kristin Wickens Tags: Research Letter Source Type: research
Alum ‐adjuvanted allergoids induce functional IgE‐blocking antibodies
This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - February 1, 2018 Category: Allergy & Immunology Authors: M. Reithofer, S.L. B öll, C. Kitzmüller, F. Horak, M. Sotoudeh, B. Bohle, B. Jahn‐Schmid Tags: Research Letter Source Type: research
Important and specific role for basophils in acute allergic reactions
This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - February 1, 2018 Category: Allergy & Immunology Authors: Peter Koro šec, Bernhard F. Gibbs, Matija Rijavec PhD, Adnan Custovic, Paul J. Turner Tags: Invited Review Source Type: research
The Effects of a CCR3 Inhibitor, AXP1275, on Allergen ‐Induced Airway Responses in Adults with Mild‐to‐Moderate Atopic Asthma
Conclusions & Clinical RelevanceAXP1275 50 mg administered daily was safe and well tolerated, and there was no difference in the type, severity, or frequency of treatment‐emergent adverse events in subjects while receiving AXP1275 compared to placebo. AXP1275 increased the methacholine PC20 however the low and variable exposure to APX1275 over a short treatment period may have contributed to poor efficacy on other outcomes.This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - February 1, 2018 Category: Allergy & Immunology Authors: G.M. Gauvreau, J.M. FitzGerald, L.P. Boulet, R.M. Watson, L. Hui, H. Villineuve, T.X. Scime, A.R. Schlatman, C. Obminski, J. Kum, S. Boehme, T.W. Ly, K.B. Bacon, P.M. O'Byrne Tags: Original Article ‐Experimental Models of Allergic Disease Source Type: research
Influence of peanut matrix on stability of allergens in gastric ‐simulated digesta: 2S albumins are main contributors to the IgE‐reactivity of short digestion resistant peptides
Conclusion and Clinical RelevancePeanut grain digestion by oral and gastric phase enzymes generates mixture of products, where the major peanut allergens remain intact and their digested peptides have preserved allergenic capacity highlighting their important roles in allergic reactions to peanut.This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - February 1, 2018 Category: Allergy & Immunology Authors: Ivana Prodic, Dragana Stanic ‐Vucinic, Danijela Apostolovic, Jelena Mihailovic, Milica Radibratovic, Jelena Radosavljevic, Lidija Burazer, Milos Milcic, Katarina Smiljanic, Marianne Hage, Tanja Cirkovic Velickovic Tags: Original Article ‐Allergens Source Type: research
Environmental peanut exposure increases the risk of peanut sensitization in high risk children
ConclusionsHigher levels of environmental exposure to peanut in the first few months of life appear to increase the probability of developing school age peanut sensitization in atopic children (based on egg sensitization and parental atopy).This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - February 1, 2018 Category: Allergy & Immunology Authors: Helen A. Brough, Inger Kull, Kerry Richards, Eva Hallner, Cilla S öderhäll, Abdel Douiri, Martin Penagos, Erik Melén, Anna Bergström, Victor Turcanu, Magnus Wickman, Gideon Lack Tags: Original Article ‐Epidemiology of Allergic Disease Source Type: research
Obese Asthmatics are Characterised by Altered Adipose Tissue Macrophage Activation
This study aimed to quantify and immuno‐phenotype adipose tissue macrophages (ATMs) from obese asthmatics and obese non‐asthmatics, and to examine associations between adipose tissue, systemic and airway inflammation.
Visceral (VAT) and sub‐cutaneous (SAT) adipose tissue were collected from obese adults undergoing bariatric surgery and processed to obtain the stromovascular fraction. Pro‐ (M1) and anti‐inflammatory (M2) macrophages were quantified by flow cytometry. Cytospins of induced sputum were stained for differential cell counts. Plasma C reactive protein (CRP) and CD163 were measured by ELISA.
VAT containe...
Source: Clinical and Experimental Allergy - January 31, 2018 Category: Allergy & Immunology Authors: Hashim A Periyalil, Lisa G Wood, Timothy A Wright, Constantin Karihaloo, Malcolm R Starkey, April S Miu, Katherine J Baines, Philip M Hansbro, Peter G Gibson Tags: Original Article ‐Asthma and Rhinitis Source Type: research
Repeated vaccination with tetanus toxoid of plasma donors with pre ‐existing specific IgE transiently elevates tetanus‐specific IgE but does not induce allergic symptoms
Clinical&Experimental Allergy,Volume 48, Issue 4, Page 479-482, April 2018. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - January 31, 2018 Category: Allergy & Immunology Source Type: research
Temperature ‐controlled laminar airflow (TLA) device in the treatment of children with severe atopic eczema: Open‐label, proof‐of‐concept study
Conclusion and Clinical RelevanceAddition of TLA device to standard pharmacological treatment may be an effective add‐on to the management of difficult‐to‐control AE.This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - January 31, 2018 Category: Allergy & Immunology Authors: Claudia Gore, Robin B. Gore, Sara Fontanella, Sadia Haider, Adnan Custovic Tags: Original Article ‐Clinical Allergy Source Type: research
Step ‐down of inhaled corticosteroids in non‐eosinophilic asthma: a prospective trial in real life
Conclusions & Clinical RelevanceWithdrawing or reducing the dose of ICS is feasible in two thirds of non‐eosinophilic asthmatics irrespective of baseline asthma control. An elevated blood eosinophil count may predict the failure to stop ICS.This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - January 31, 2018 Category: Allergy & Immunology Authors: Sophie Demarche, Florence Schleich, Monique Henket, Virginie Paulus, Renaud Louis, Thierry Van Hees Tags: Original Article ‐Asthma and Rhinitis Source Type: research
Repeated vaccination with tetanus toxoid of plasma donors with pre ‐existing specific IgE transiently elevates tetanus‐specific IgE but does not induce allergic symptoms
This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - January 31, 2018 Category: Allergy & Immunology Authors: Peter ‐Paul A. Unger, Mateusz Makuch, Marja Aalbers, Ninotska I.L. Derksen, Anja ten Brinke, Rob C. Aalberse, Theo Rispens, S. Marieke van Ham Tags: Research Letter Source Type: research
