The familial aggregation of atopic diseases and depression or anxiety in children
Conclusions and Clinical RelevanceAtopic diseases and depression or anxiety tend to occur together in families, therefore when treating for one disease the physician should consider comorbidity in both the individual and the individual's siblings. We did not find evidence to support a genetic explanation for comorbidity and further exploration is needed to disentangle the environmental and epigenetic reasons for familial aggregation.This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - March 7, 2018 Category: Allergy & Immunology Authors: Bronwyn K Brew, Cecilia Lundholm, Tong Gong, Henrik Larsson, Catarina Almqvist Tags: Original Article ‐Epidemiology of Allergic Disease Source Type: research
Step ‐down of inhaled corticosteroids in non‐eosinophilic asthma: A prospective trial in real life
Clinical&Experimental Allergy, EarlyView. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - March 6, 2018 Category: Allergy & Immunology Source Type: research
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Clinical&Experimental Allergy, Ahead of Print. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - March 6, 2018 Category: Allergy & Immunology Source Type: research
2S protein Ara h 7.0201 has unique epitopes compared to other Ara h 7 isoforms and is comparable to 2S proteins Ara h 2 and 6 in basophil degranulation capacity
Conclusion & clinical relevanceThe majority of peanut‐allergic patients are sensitized to isoform Ara h 7.0201, which is functionally as active as Ara h 2.0201 and 6.01. Unique epitopes are most likely located in the C‐terminus or an allergenic loop region which is a known allergenic epitope region for Ara h 2.0201 and 6.01. Due to its unique epitopes and allergenicity, it is an interesting candidate to improve the diagnostic accuracy for peanut allergy.This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - March 1, 2018 Category: Allergy & Immunology Authors: S.M. Hayen, A.M. Ehlers, C.F. den Hartog Jager, J. Garssen, E.F. Knol, A.C. Knulst, W. Suer, L.E.M Willemsen, H.G. Otten Tags: Original Article ‐Allergens Source Type: research
Effects of personal air pollution exposure on asthma symptoms, lung function and airway inflammation
Conclusions and clinical relevanceWe did not find compelling evidence that air pollution exposure impacts on day‐to‐day clinical control in an unselected asthma population, but further studies are required in larger populations with higher exposure levels. Women may be more susceptible than men to the effects of air pollution, an observation which requires confirmation in future studies.This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - March 1, 2018 Category: Allergy & Immunology Authors: Lucy Chambers, Joanne Finch, Karen Edwards, Antoine Jeanjean, Roland Leigh, Sherif Gonem Tags: Original Article ‐Asthma and Rhinitis Source Type: research
Complex Association Patterns for Inflammatory Mediators in Induced Sputum from Subjects with Asthma
ConclusionsSputum cytokines, chemokines and growth factors were increased in severe asthma, primarily with increased neutrophils. Factor analysis identified complex inflammatory protein interactions, suggesting airway inflammation in asthma is characterized by overlapping immune pathways. Thus, focus on a single specific inflammatory mediator or pathway may limit understanding the complexity of inflammation underlying airway changes in asthma and selection of appropriate therapy.This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - March 1, 2018 Category: Allergy & Immunology Authors: A T Hastie, C Steele, C W Dunaway, W C Moore, B M Rector, E Ampleford, H Li, L C Denlinger, N Jarjour, D A Meyers, E.R. Bleecker, Tags: Original Article ‐Asthma and Rhinitis Source Type: research
Novel innate and adaptive lymphocytes: the new players in the pathogenesis of inflammatory upper airway diseases
This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - March 1, 2018 Category: Allergy & Immunology Authors: Yang Liu, Yin Yao, Zhi ‐Chao Wang, Qing Ning, Zheng Liu Tags: Unsolicited Review Source Type: research
Dental Follicle Mesenchymal Stem Cells Downregulate Th2 Mediated Immune Response in Asthmatic Patients Mononuclear Cells
ConclusionDFSCs suppressed allergen‐induced Th2‐cell polarization in favor of Th1 responses and attenuated antigen‐presenting cell co‐stimulatory activities. These studies suggest that DFSC‐based cell therapy may provide pro‐tolerogenic immunomodulation relevant to allergic diseases such as asthma.This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - March 1, 2018 Category: Allergy & Immunology Authors: Deniz Gen ç, Noushin Zibandeh, Ercan Nain, Muazzez Gökalp, Ahmet Oğuzhan Özen, Mehmet Kamil Göker, Tunç Akkoç Tags: Original Article ‐Asthma and Rhinitis Source Type: research
Component ‐resolved diagnostics demonstrates that most peanut‐allergic individuals could potentially introduce tree nuts to their diet
Clinical&Experimental Allergy, EarlyView. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - February 28, 2018 Category: Allergy & Immunology Source Type: research
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Clinical&Experimental Allergy, Ahead of Print. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - February 28, 2018 Category: Allergy & Immunology Source Type: research
Clinical reactivity of celery cultivars in allergic patients: Role of Api g 1
Conclusions and Clinical RelevanceTaken together, the data from this study suggest that cultivar Anita is better tolerated in celery‐allergic patients than “Prinz.” Differences in the protein expression profile between the cultivars, particularly the different content of Api g 1, could cause the different allergenicity. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - February 28, 2018 Category: Allergy & Immunology Authors: S. D ölle, S. Welter, E. Ruppel, K. Lehmann, D. Schwarz, E. Jensen‐Jarolim, P. Zieglmayer, P. Franken, M. Worm Tags: ORIGINAL ARTICLE Source Type: research
Component ‐resolved diagnostics demonstrates that most peanut‐allergic individuals could potentially introduce tree nuts to their diet
Conclusions and clinical relevancePR‐10‐sensitizations were frequent and strong regardless of peanut allergy status. Component‐resolved diagnostics can be employed to demonstrate to patients that sensitization to seed storage proteins of tree nuts is uncommon. Several tree nuts could potentially be reintroduced to the diet. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - February 28, 2018 Category: Allergy & Immunology Authors: R. Uotila, A. K. Kukkonen, W. M. Blom, B. Remington, J. Westerhout, A. S. Pelkonen, M. J. M äkelä Tags: ORIGINAL ARTICLE Source Type: research
Development and validation of the Cholinergic Urticaria Quality ‐of‐Life Questionnaire (CholU‐QoL)
Conclusions and Clinical RelevanceThe CholU‐QoL is the first disease‐specific QoL instrument for CholU and also the first specific QoL measure in the field of chronic inducible urticarias. It may serve as a valuable tool for clinical trials and improve routine patient management. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - February 28, 2018 Category: Allergy & Immunology Authors: J. Ruft, A. Asady, P. Staubach, T. Casale, G. Sussmann, T. Zuberbier, M. Maurer, K. Weller, S. Altrichter Tags: ORIGINAL ARTICLE Source Type: research
