Birth order and paediatric allergic disease: A nationwide longitudinal survey
ConclusionThe influence of birth order depended on the type of allergic disease and the childhood period. Childhood is unique in terms of physical and immunological development, and the immune response to the post‐natal environment in childhood appears to be heterogeneous. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - February 27, 2018 Category: Allergy & Immunology Authors: T. Kikkawa, T. Yorifuji, Y. Fujii, M. Yashiro, A. Okada, M. Ikeda, H. Doi, H. Tsukahara Tags: ORIGINAL ARTICLE Source Type: research
Alternaria alternata challenge at the nasal mucosa results in eosinophilic inflammation and increased susceptibility to influenza virus infection
Conclusions and Clinical RelevanceRepetitive administration of A. alternata resulted in inflammation of the nasal mucosae and unanticipated morbidity and mortality in response to subsequent challenge with influenza virus. Interestingly, and in contrast to findings in the lower airways, eosinophils recruited to the nasal passages provided no protection against lethal infection. As increased susceptibility to influenza virus among individuals with rhinitis has been the subject of several clinical reports, this model may be used for further exploration of these observations.This article is protected by copyright. All rights r...
Source: Clinical and Experimental Allergy - February 23, 2018 Category: Allergy & Immunology Authors: Michelle Ma, Jamie L. Redes, Caroline M. Percopo, Kirk M. Druey, Helene F. Rosenberg Tags: Original Article ‐Basic Mechanisms in Allergic Disease Source Type: research
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Clinical&Experimental Allergy, Ahead of Print. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - February 22, 2018 Category: Allergy & Immunology Source Type: research
The Blomia tropicalis allergen Blo t 7 stimulates innate immune signalling pathways through TLR2
Conclusions & Clinical RelevanceThrough its propensity to transport fatty acids/lipids and to stimulate TLR2 signalling pathways in airway epithelial cells, Blo t 7 can represent a key allergen for the initiation of the B. tropicalis‐induced airway inflammation. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - February 22, 2018 Category: Allergy & Immunology Authors: T. Soongrung, K. Mongkorntanyatip, T. Peepim, A. Buaklin, M. Le Mignon, N. Malainual, E. Nony, A. Jacquet Tags: ORIGINAL ARTICLE Source Type: research
Effects of human rhinovirus on epithelial barrier integrity and function in children with asthma
Clinical&Experimental Allergy, EarlyView. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - February 20, 2018 Category: Allergy & Immunology Source Type: research
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Clinical&Experimental Allergy, Ahead of Print. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - February 20, 2018 Category: Allergy & Immunology Source Type: research
Interleukin ‐17A and vascular remodelling in severe asthma; lack of evidence for a direct role
Conclusions & Clinical RelevanceOur results shed light on the role of IL‐17A in vascular remodelling, most likely through stimulating the synthesis of other angiogenic factors. Knowledge of these pathways may aid in the identification of new therapeutic targets. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - February 20, 2018 Category: Allergy & Immunology Authors: A. Panariti, C. J. Baglole, V. Sanchez, D. H. Eidelman, S. Hussain, R. Olivenstein, J. G. Martin, Q. Hamid Tags: ORIGINAL ARTICLE Source Type: research
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Clinical&Experimental Allergy, Ahead of Print. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - February 19, 2018 Category: Allergy & Immunology Source Type: research
Uncontrolled asthmatics have increased FceRI+ and TGF ‐β–positive MCTC mast cells and collagen VI in the alveolar parenchyma
ConclusionsPatients with uncontrolled atopic asthma have an altered pro‐fibrotic MCTC phenotype in the alveolar parenchyma that is associated with alveolar collagen VI. The present data thus support distal lung mast cell and matrix changes as histopathological features of asthma that may be of particular clinical relevance in patients who have remaining symptoms despite conventional inhaler therapy. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - February 15, 2018 Category: Allergy & Immunology Authors: C. K. Andersson, M. Weitoft, K. Rydell ‐Törmänen, L. Bjermer, G. Westergren‐Thorsson, J. S. Erjefält Tags: ORIGINAL ARTICLE Source Type: research
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Clinical&Experimental Allergy, Ahead of Print. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - February 14, 2018 Category: Allergy & Immunology Source Type: research
Short chain fatty acids induce tissue plasminogen activator in airway epithelial cells via GPR41 & 43
Conclusions & Clinical RelevanceSCFAs were shown to induce airway epithelial cell expression of t‐PA via GPR41 and GPR43. Topical delivery of potent compounds that activate these receptors may have value by reducing fibrin deposition and shrinking nasal polyp growth.This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - February 12, 2018 Category: Allergy & Immunology Authors: Yoshimasa Imoto, Atsushi Kato, Tetsuji Takabayashi, Masafumi Sakashita, James E. Norton, Lydia A. Suh, Roderick G. Carter, Ava R Weibman, Kathryn E. Hulse, Whitney Stevens, Kathleen E. Harris, Anju T. Peters, Leslie C. Grammer, Bruce K. Tan, Kevin Welch, Tags: Original Article ‐Basic Mechanisms in Allergic Disease Source Type: research
The effects of a CCR3 inhibitor, AXP1275, on allergen ‐induced airway responses in adults with mild‐to‐moderate atopic asthma
Clinical&Experimental Allergy,Volume 48, Issue 4, Page 445-451, April 2018. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - February 9, 2018 Category: Allergy & Immunology Source Type: research
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Clinical&Experimental Allergy, Ahead of Print. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - February 8, 2018 Category: Allergy & Immunology Source Type: research
