Alternaria alternata challenge at the nasal mucosa results in eosinophilic inflammation and increased susceptibility to influenza virus infection

Conclusions and Clinical RelevanceRepetitive administration of A. alternata resulted in inflammation of the nasal mucosae and unanticipated morbidity and mortality in response to subsequent challenge with influenza virus. Interestingly, and in contrast to findings in the lower airways, eosinophils recruited to the nasal passages provided no protection against lethal infection. As increased susceptibility to influenza virus among individuals with rhinitis has been the subject of several clinical reports, this model may be used for further exploration of these observations.This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - Category: Allergy & Immunology Authors: Tags: Original Article ‐Basic Mechanisms in Allergic Disease Source Type: research