2S protein Ara h 7.0201 has unique epitopes compared to other Ara h 7 isoforms and is comparable to 2S proteins Ara h 2 and 6 in basophil degranulation capacity

Conclusion & clinical relevanceThe majority of peanut‐allergic patients are sensitized to isoform Ara h 7.0201, which is functionally as active as Ara h 2.0201 and 6.01. Unique epitopes are most likely located in the C‐terminus or an allergenic loop region which is a known allergenic epitope region for Ara h 2.0201 and 6.01. Due to its unique epitopes and allergenicity, it is an interesting candidate to improve the diagnostic accuracy for peanut allergy.This article is protected by copyright. All rights reserved.

Source: Clinical and Experimental Allergy - March 1, 2018 Category: Allergy & Immunology Authors: S.M. Hayen, A.M. Ehlers, C.F. den Hartog Jager, J. Garssen, E.F. Knol, A.C. Knulst, W. Suer, L.E.M Willemsen, H.G. Otten Tags: Original Article ‐Allergens Source Type: research