Inhibition of metabolic disorders in vivo and in vitro by main constituent of Coreopsis tinctoria
ConclusionThe results revealed that EAEC ameliorates IR in rats, and marein has the potential to improve IR by ameliorating glucose metabolism disorders. (Source: Chinese Herbal Medicines)
Source: Chinese Herbal Medicines - July 10, 2018 Category: Complementary Medicine Source Type: research
Salidroside shows a particular pharmacokinetic property in model rats of myocardial ischemia
ConclusionThe particular PK properties of salidroside in ischemic model rats were presented in our study for the first time, suggesting that myocardial ischemia greatly affected pharmacokinetics exposure of the orally administrated salidroside after a single or multiple doses. (Source: Chinese Herbal Medicines)
Source: Chinese Herbal Medicines - July 10, 2018 Category: Complementary Medicine Source Type: research
Protective effects of combination of Xuesaitong and aspirin on cerebral ischemia and reperfusion injury in rats
ConclusionThe combination of XST and aspirin significantly inhibited oxidative stress and inflammation in serum, cerebral cortex, and hippocampus of MCAO/R rats. The combination of XST and aspirin exerted more protective effects than XST or aspirin treatment alone. The combination of XST and aspirin might provide the synergistic therapeutic effects on CIRI, and deserve further clinical investigation. (Source: Chinese Herbal Medicines)
Source: Chinese Herbal Medicines - July 10, 2018 Category: Complementary Medicine Source Type: research
Identification and quality analysis of Panax notoginseng and Panax vietnamensis var. fuscidicus through integrated DNA barcoding and HPLC
ConclusionITS2 is a rapid and efficient method to identify P. notoginseng and P. vietnamensis var. fuscidicus. HPLC analysis indicated that pharmacological action might be different between P. notoginseng and P. vietnamensis var. fuscidicus. (Source: Chinese Herbal Medicines)
Source: Chinese Herbal Medicines - July 10, 2018 Category: Complementary Medicine Source Type: research
Molecular mechanism of quercitrin on osteogenic differentiation and adipogenic differentiation of rat bone marrow stromal stem cells (rBMSCs)
ConclusionThis study suggested that quercitrin not only stimulated osteogenic differentiation but also inhibited adipogenic differentiation of rBMSCs, which was associated with the up-regulation of Runx2, BMP-2, and OSX mRNA expression and the down-regulation of PPARγ, C/EBPα, and aP2 mRNA expression. (Source: Chinese Herbal Medicines)
Source: Chinese Herbal Medicines - July 10, 2018 Category: Complementary Medicine Source Type: research
Protection of Shuxuetong combined with aspirin against cerebral ischemia/reperfusion injury through ameliorating coagulation and fibrinolysis system
ConclusionSXT combined with aspirin can effectively inhibit platelet activation, regulate the maximum concentration of platelets, and improve coagulation function and fibrinolysis system. (Source: Chinese Herbal Medicines)
Source: Chinese Herbal Medicines - July 10, 2018 Category: Complementary Medicine Source Type: research
Effect of high exposure of chlorogenic acid on lipid accumulation and oxidative stress in oleic acid-treated HepG2 cells
ConclusionOur results suggest that high concentrations of CGA ameliorated OA-induced oxidative damage and IR likely by inhibiting the expression of CYP2E1 and CYP4A, and promoted lipid accumulation by inducing the expression of SREBP-1c and PNPLA3 in the tested cells. (Source: Chinese Herbal Medicines)
Source: Chinese Herbal Medicines - July 10, 2018 Category: Complementary Medicine Source Type: research
Comparative brain pharmacokinetic study of Jiaotai pills in normal and insomnic rats using brain microdialysis combinated with LC–MS/MS
ConclusionThe LC-MS/MS method combinated with microdialysis is useful in the brain pharmacokinetic study of five protoberberine-type alkaloids. The results indicated that the rates of analytes absorption in insomnic rats were significantly higher than those in normal rats. Besides, the protoberberine-type alkaloids could bring a direct effect on the neuron in the hippocampus. (Source: Chinese Herbal Medicines)
Source: Chinese Herbal Medicines - July 10, 2018 Category: Complementary Medicine Source Type: research
Hederacolchiside A1 suppresses proliferation of tumor cells by inducing apoptosis through modulating PI3K/Akt/mTOR signaling pathway
ConclusionThese data indicated that hederacolchiside A1 suppressed the proliferation of human tumor cells by inducing apoptosis through modulating the PI3K/Akt/mTOR signaling pathway. (Source: Chinese Herbal Medicines)
Source: Chinese Herbal Medicines - July 10, 2018 Category: Complementary Medicine Source Type: research
Chemical constituents from Kalanchoe hybrida and their cytotoxicity
ConclusionThe results indicated that these principles should be responsible for the bioactivity of corresponding partial fractions. The potential constituents could be further investigated to explore the new natural lead drugs. (Source: Chinese Herbal Medicines)
Source: Chinese Herbal Medicines - July 10, 2018 Category: Complementary Medicine Source Type: research
Scientific understanding of toxicity and safety of Chinese medicines
Publication date: April 2018Source: Chinese Herbal Medicines, Volume 10, Issue 2Author(s): Chang-xiao Liu (Source: Chinese Herbal Medicines)
Source: Chinese Herbal Medicines - July 10, 2018 Category: Complementary Medicine Source Type: research
Application and prospect of toxicity quality markers of Chinese materia medica based on metabolomics
Publication date: April 2018Source: Chinese Herbal Medicines, Volume 10, Issue 2Author(s): Peng-jie Zhang, Ya-mei Li, Ya-ni Zhang, Wei Huang, Yu-bo Li, Yan-jun Zhang, Chang-xiao LiuAbstractIn view of the problem that the quality evaluation indicators divorced from effectiveness and safety in Chinese materia medica (CMM), Prof. Chang-xiao Liu et al have put forward a concept of quality markers (Q-markers) of CMM, which provided a new thought for improving the CMM quality control method. The toxicity Q-markers of CMM are described as follows, the early toxicity prediction of CMM, the discovery, formation and susceptibility ...
Source: Chinese Herbal Medicines - July 10, 2018 Category: Complementary Medicine Source Type: research
Extrinsic harmful residues in Chinese herbal medicines: types, detection, and safety evaluation
Publication date: April 2018Source: Chinese Herbal Medicines, Volume 10, Issue 2Author(s): Cong-min Liu, Jia-an Qin, Xiao-wen Dou, Mei-hua Yang, Xiao-bo SunAbstractChinese herbal medicines (CHMs) are playing important roles in the treatment of diseases and human health care throughout the world. However, the extrinsic harmful residues have been threatening the therapies by destroying CHMs qualtiy which hinders the international trades of CHMs. This review summarized the extrinsic harmful residues contaminating CHMs in types, detection methods, national and international regulations, and made safety evaluations according to...
Source: Chinese Herbal Medicines - July 10, 2018 Category: Complementary Medicine Source Type: research
Synergistic effect and different toxicities of adjuvant components of Realgar–Indigo Naturalis formula
ConclusionBased on the collective experimental results presented here, it can be concluded that the toxicity of RIF is the result of the soluble arsenic in Realgar and that the I. naturalis and S. miltiorrhiza in the RIF exert completely opposite effects on the toxicity of Realgar. This maybe an intelligent explanation for the compatibility of this formula, and this RIF study may therefore be viewed as a classic case of traditional Chinese medicine research on compatibility. (Source: Chinese Herbal Medicines)
Source: Chinese Herbal Medicines - July 10, 2018 Category: Complementary Medicine Source Type: research
Deep in shadows: Epigenetic and epigenomic regulations of medicinal plants
Publication date: Available online 4 May 2018Source: Chinese Herbal MedicinesAuthor(s): Da-Cheng Hao, Pei-Gen XiaoAbstractAround 60% of the extant plants have medicinal and health-promoting values. Genuine medicinal material (geoherb) is produced in particular geographic regions, that is defined ecological environment and cultivation pipeline. The clinical efficacy of a geoherb is superior to that of the same medicinal plant growing in other regions. The special medicinal features of a plant are determined by its genome, while the proper ecological conditions have major effects on the formation of a geoherb, which is at le...
Source: Chinese Herbal Medicines - July 10, 2018 Category: Complementary Medicine Source Type: research
