Application and prospect of toxicity quality markers of Chinese materia medica based on metabolomics

Publication date: April 2018Source: Chinese Herbal Medicines, Volume 10, Issue 2Author(s): Peng-jie Zhang, Ya-mei Li, Ya-ni Zhang, Wei Huang, Yu-bo Li, Yan-jun Zhang, Chang-xiao LiuAbstractIn view of the problem that the quality evaluation indicators divorced from effectiveness and safety in Chinese materia medica (CMM), Prof. Chang-xiao Liu et al have put forward a concept of quality markers (Q-markers) of CMM, which provided a new thought for improving the CMM quality control method. The toxicity Q-markers of CMM are described as follows, the early toxicity prediction of CMM, the discovery, formation and susceptibility research of toxicity Q-markers of CMM. Metabolomics is a systematic biology approach, closely related to the toxicity phenotype of organism, has unique advantages in toxicity Q-markers research. The toxicity Q-markers of CMM are explained from the following four aspects in this review: 1) the establishment of toxicity prediction model of CMM, which is based on metabolomics, pattern recognition, and other techniques; 2) the discovery of toxicity Q-markers of CMM based on metabolomic, which is meaning that the toxicity Q-markers are interpreted regarding to the chemical composition analysis of CMM, preliminary screening and verification of the toxicity Q-markers and toxicity mechanism research; 3) the research on the formation of toxicity Q-markers based on metabolomics, which is described from biosynthetic pathway analysis and the secondary metabolites analys...

Source: Chinese Herbal Medicines - July 10, 2018 Category: Complementary Medicine Source Type: research