Ex Vivo Culture of Cells Derived From Circulating Tumour Cell Xenograft to support Small Cell Lung Cancer Research and Experimental Therapeutics
Conclusion and ImplicationsShort term cultures of CDX provide a tractable platform to screen new treatments, identify predictive and pharmacodynamic biomarkers and interrogate mechanisms of resistance to better understand progression of this recalcitrant tumour. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - November 14, 2018 Category: Drugs & Pharmacology Authors: Alice Lallo,
Sakshi Gulati,
Maximilian W Schenk,
Garima Khandelwal,
Ulrika Warpman Berglund,
Ioannis S Pateras,
Christopher P E Chester,
Therese M Pham,
Christina Kalderen,
Kristopher K Frese,
Vassilis G Gorgoulis,
Crispin Miller,
Fiona Blackh Tags: RESEARCH PAPER Source Type: research
Sex bias in preclinical research and an exploration of how to change the status quo
There has been a revolution within clinical trials to include females in the research pipeline. However, there has been limited change in the preclinical arena; yet the research here lays the ground work for the subsequent clinical trials. Sex bias has been highlighted as one of the contributing factors to the poor translation and replicability issues undermining preclinical research. There have been multiple calls for action and the funders of biomedical research are actively pushing the inclusion of sex as a biological variable. Here we consider the current standard practice within the preclinical research setting, why t...
Source: British Journal of Pharmacology - November 12, 2018 Category: Drugs & Pharmacology Authors: Natasha A Karp,
Neil Reavey Tags: REVIEW ARTICLE THEMED ISSUE Source Type: research
Histamine Receptors and Cancer Pharmacology: An Update
In the present review we will discuss the recent advances in the understanding of the role of histamine and histamine receptors in cancer biology. The controversial role of the histaminergic system in different neoplasias including gastric, colorectal, oesophageal, oral, pancreatic, liver, lung, skin, blood and breast cancers will be reviewed. The expression of histamine receptor subtypes, with special emphasis in histamine H4 receptor (H4R), in different cell lines and human tumours, the signal transduction pathways and the associated biological responses as well as thein vivo treatment of experimental tumours with pharma...
Source: British Journal of Pharmacology - November 10, 2018 Category: Drugs & Pharmacology Authors: Noelia A Massari,
Melisa B Nicoud,
Vanina A Medina Tags: REVIEW ARTICLE THEMED ISSUE Source Type: research
Th1 type immune responses to Porphyromonas gingivalis antigens exacerbate Angiotensin II dependent hypertension and vascular dysfunction.
Conclusion and ImplicationsThese studies support the concept that Th1 immune responses induced by bacterial antigens such asP. gingivalis can increase sensitivity to sub ‐pressor pro‐hypertensive insults such as low dose Angiotensin II, therefore providing a mechanistic link between chronic infection such as periodontitis and hypertension. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - November 10, 2018 Category: Drugs & Pharmacology Authors: Marta Cze śnikiewicz‐Guzik,
Ryszard Nosalski,
Tomasz P Mikolajczyk,
Francesca Vidler,
Tomasz Dohnal,
Elzbieta Dembowska,
Delyth Graham,
David G Harrison,
Tomasz J Guzik Tags: RESEARCH PAPER THEMED ISSUE Source Type: research
Mitochondrial protective effect of neferine through the modulation of Nrf2 signalling in ischemic stroke
Conclusions and implicationsThe data in this study demonstrated that Nef might have therapeutic potential for ischemic stroke and may exert its protective role through mitochondrial protection. In addition, this protection might be attributed to the modulation of Nrf2 signalling. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - November 10, 2018 Category: Drugs & Pharmacology Authors: Chuanhong Wu,
Jianxin Chen,
Ruocong Yang,
Feipeng Duan,
Shaojing Li,
Xiuping Chen Tags: RESEARCH PAPER Source Type: research
SIRT1 represses PKC ‐zeta activity via regulating interplay of acetylation and phosphorylation in cardiac hypertrophy
Conclusions and ImplicationsSIRT1 is an endogenous negative regulator for PKC ‐zeta and mediates its activity via regulating the acetylation and phosphorylation in the pathogenesis of cardiac hypertrophy. Targeting SIRT1‐PKC‐zeta signaling axis may suggest a novel therapeutic approach against cardiac hypertrophy. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - November 10, 2018 Category: Drugs & Pharmacology Authors: Jingyan Li,
Junying Huang,
Jing Lu,
Zhen Guo,
Zhuoming Li,
Hui Gao,
Panxia Wang,
Wenwei Luo,
Sidong Cai,
Yuehuai Hu,
Kaiteng Guo,
Luping Wang,
Zhenzhen Li,
Minghui Wang,
Xiaolei Zhang,
Peiqing Liu Tags: RESEARCH PAPER Source Type: research
Histamine Receptors and Cancer Pharmacology: An Update
In the present review we will discuss the recent advances in the understanding of the role of histamine and histamine receptors in cancer biology. The controversial role of the histaminergic system in different neoplasias including gastric, colorectal, oesophageal, oral, pancreatic, liver, lung, skin, blood and breast cancers will be reviewed. The expression of histamine receptor subtypes, with special emphasis in histamine H4 receptor (H4R), in different cell lines and human tumours, the signal transduction pathways and the associated biological responses as well as thein vivo treatment of experimental tumours with pharma...
Source: British Journal of Pharmacology - November 10, 2018 Category: Drugs & Pharmacology Authors: Noelia A Massari,
Melisa B Nicoud,
Vanina A Medina Tags: REVIEW ARTICLE THEMED ISSUE Source Type: research
Th1 type immune responses to Porphyromonas gingivalis antigens exacerbate Angiotensin II dependent hypertension and vascular dysfunction.
Conclusion and ImplicationsThese studies support the concept that Th1 immune responses induced by bacterial antigens such asP. gingivalis can increase sensitivity to sub ‐pressor pro‐hypertensive insults such as low dose Angiotensin II, therefore providing a mechanistic link between chronic infection such as periodontitis and hypertension. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - November 10, 2018 Category: Drugs & Pharmacology Authors: Marta Cze śnikiewicz‐Guzik,
Ryszard Nosalski,
Tomasz P Mikolajczyk,
Francesca Vidler,
Tomasz Dohnal,
Elzbieta Dembowska,
Delyth Graham,
David G Harrison,
Tomasz J Guzik Tags: RESEARCH PAPER THEMED ISSUE Source Type: research
Mitochondrial protective effect of neferine through the modulation of Nrf2 signalling in ischemic stroke
Conclusions and implicationsThe data in this study demonstrated that Nef might have therapeutic potential for ischemic stroke and may exert its protective role through mitochondrial protection. In addition, this protection might be attributed to the modulation of Nrf2 signalling. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - November 10, 2018 Category: Drugs & Pharmacology Authors: Chuanhong Wu,
Jianxin Chen,
Ruocong Yang,
Feipeng Duan,
Shaojing Li,
Xiuping Chen Tags: RESEARCH PAPER Source Type: research
SIRT1 represses PKC ‐zeta activity via regulating interplay of acetylation and phosphorylation in cardiac hypertrophy
Conclusions and ImplicationsSIRT1 is an endogenous negative regulator for PKC ‐zeta and mediates its activity via regulating the acetylation and phosphorylation in the pathogenesis of cardiac hypertrophy. Targeting SIRT1‐PKC‐zeta signaling axis may suggest a novel therapeutic approach against cardiac hypertrophy. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - November 10, 2018 Category: Drugs & Pharmacology Authors: Jingyan Li,
Junying Huang,
Jing Lu,
Zhen Guo,
Zhuoming Li,
Hui Gao,
Panxia Wang,
Wenwei Luo,
Sidong Cai,
Yuehuai Hu,
Kaiteng Guo,
Luping Wang,
Zhenzhen Li,
Minghui Wang,
Xiaolei Zhang,
Peiqing Liu Tags: RESEARCH PAPER Source Type: research
Immune cells in the tumour: new routes of retinoids for chemoprevention and chemotherapeutics
Retinoids, vitamin A and its natural and synthetic analogues have various functions, including being involved in cell proliferation and differentiation and participating in the formation of vertebrate morphology. In addition, they may activate certain tumour suppressor genes that then act as tumour inhibitors. In the past decades, retinoids have been regarded as promising chemotherapeutic and chemopreventive agents; however, their mechanisms are still not fully understood. Immune cells that participate in or are associated with the immune response play vital roles in the initiation and development of many cancers. Interest...
Source: British Journal of Pharmacology - November 8, 2018 Category: Drugs & Pharmacology Authors: Li Jiang,
Rong Dong,
Meidan Ying,
Qiaojun He,
Ji Cao,
Bo Yang Tags: REVIEW ARTICLE Source Type: research
Different mechanisms involved in liraglutide and glucagon ‐like peptide‐1 vasodilatation in rat mesenteric small arteries
Conclusion and ImplicationsOur findings suggest that a GLP ‐1 receptor‐dependent mechanism is involved in liraglutide relaxation in branched arteries in normoglycemic conditions, while GLP‐1 inhibition of vascular superoxide levels contributes to GLP‐1 receptor‐independent potentiation of endothelium‐dependent vasodilatation in hyperglycemia. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - November 7, 2018 Category: Drugs & Pharmacology Authors: Maj Bangshaab,
Alejandro Gutierrez,
Khiem Dinh Huynh,
Jakob Sch öllhammer Knudsen,
Daniel Dias Rufino Arcanjo,
Asbjørn G Petersen,
Jørgen Rungby,
Michael Gejl,
Ulf Simonsen Tags: RESEARCH PAPER Source Type: research
