Exogenous IL ‐19 attenuates acute ischemic injury and improves survival in male mice with myocardial infarction
Conclusions and ImplicationsIL ‐19 attenuated acute ischemic injury and improved survival of mice with MI, and the mechanisms involved induction of HO‐1, M2 macrophage polarization, angiogenesis, and STAT3 activation. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - November 20, 2018 Category: Drugs & Pharmacology Authors: Weishuai An,
Yongsheng Yu,
Yuefan Zhang,
Zhigang Zhang,
Yunhua Yu,
Xianxian Zhao Tags: RESEARCH PAPER Source Type: research
Characterization of kinetics of human cytochrome P450s involved in bioactivation of flucloxacillin: inhibition of CYP3A ‐catalyzed hydroxylation by sulfaphenazole
Conclusions and implicationsThe combined results show that the 5 ’‐hydroxylation of FLX is primarily catalysed by CYP3A4, CYP3A7 and CYP2C9. The large variability of the hepatic expression of these enzymes could affect the formation of 5’‐hydroxymethylfucloxacillin, which may determine the differences in susceptibility to flucloxacillin‐induced liver in jury. Additionally, the strong inhibition in CYP3A‐catalyzed flucloxacillin metabolism by sulfaphenazole suggest that unanticipated drug‐drug interactions could occur with coadministered drugs. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - November 17, 2018 Category: Drugs & Pharmacology Authors: Stefan J Dekker,
Floor Dohmen,
Nico P E Vermeulen,
Jan N M Commandeur Tags: RESEARCH PAPER Source Type: research
Issue Information
British Journal of Pharmacology, Volume 175, Issue 23, Page 4283-4284, December 2018. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - November 16, 2018 Category: Drugs & Pharmacology Tags: ISSUE INFORMATION Source Type: research
Regulation of heterologously expressed 5 ‐HT1B receptors coupling to K channels in AtT‐20 cells
Conclusions and ImplicationsIn AtT ‐20 cells, 5‐HT1B receptors undergo rapid and reversible desensitization at concentrations of agonist similar to those required to activate the receptor. Desensitization is incomplete, and the continued signalling of the receptor in the presence of the agonist may lead to cellular adaptations. Finally, 5 ‐HT1B receptor activation causes significant heterologous desensitization, which may lead to a reduced effectiveness of unrelated drugsin vivo. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - November 16, 2018 Category: Drugs & Pharmacology Authors: Marika Heblinski,
Christopher Bladen,
Mark Connor Tags: RESEARCH PAPER Source Type: research
Harnessing stem cells and biomaterials to promote neural repair
With the limited capacity for self ‐repair in the adult central nervous system, efforts to stimulate quiescent stem cell populations within discrete brain regions, as well as harness the potential of stem cell transplants, offers significant hope for neural repair. These new cells are capable of providing trophic cues to support re sidual host populations and/or replace those cells lost to the primary insult. However, issues with low level adult neurogenesis, cell survival, directed differentiation, and inadequate reinnervation of host tissue have impeded the full potential of these therapeutic approaches and their clini...
Source: British Journal of Pharmacology - November 16, 2018 Category: Drugs & Pharmacology Authors: K F Bruggeman,
N Moriarty,
E Dowd,
D R Nisbet,
C L Parish Tags: REVIEW ARTICLE Source Type: research
The involvement of microglia in Alzheimer's disease: a new dog in the fight.
First described clinically in 1906, Alzheimer's disease (AD) is the most common neurodegenerative disease and form of dementia worldwide. Despite its prevalence, only five therapies are currently approved for AD, all dealing with the symptoms rather than the underlying causes of the disease. A multitude of experimental evidence has suggested that the once thought inconsequential process of neuroinflammation does, in fact, contribute to the AD pathogenesis. One such central nervous system (CNS) cell type critical to this process are microglia. Plastic in nature with varied roles, microglia are emerging as key contributors t...
Source: British Journal of Pharmacology - November 16, 2018 Category: Drugs & Pharmacology Authors: Zachery Moore,
Juliet M Taylor,
Peter J Crack Tags: REVIEW ARTICLE THEMED ISSUE Source Type: research
Issue Information
British Journal of Pharmacology, Volume 175, Issue 23, Page 4283-4284, December 2018. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - November 16, 2018 Category: Drugs & Pharmacology Tags: ISSUE INFORMATION Source Type: research
Regulation of heterologously expressed 5 ‐HT1B receptors coupling to K channels in AtT‐20 cells
Conclusions and ImplicationsIn AtT ‐20 cells, 5‐HT1B receptors undergo rapid and reversible desensitization at concentrations of agonist similar to those required to activate the receptor. Desensitization is incomplete, and the continued signalling of the receptor in the presence of the agonist may lead to cellular adaptations. Finally, 5 ‐HT1B receptor activation causes significant heterologous desensitization, which may lead to a reduced effectiveness of unrelated drugsin vivo. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - November 16, 2018 Category: Drugs & Pharmacology Authors: Marika Heblinski,
Christopher Bladen,
Mark Connor Tags: RESEARCH PAPER Source Type: research
Harnessing stem cells and biomaterials to promote neural repair
With the limited capacity for self ‐repair in the adult central nervous system, efforts to stimulate quiescent stem cell populations within discrete brain regions, as well as harness the potential of stem cell transplants, offers significant hope for neural repair. These new cells are capable of providing trophic cues to support re sidual host populations and/or replace those cells lost to the primary insult. However, issues with low level adult neurogenesis, cell survival, directed differentiation, and inadequate reinnervation of host tissue have impeded the full potential of these therapeutic approaches and their clini...
Source: British Journal of Pharmacology - November 16, 2018 Category: Drugs & Pharmacology Authors: K F Bruggeman,
N Moriarty,
E Dowd,
D R Nisbet,
C L Parish Tags: REVIEW ARTICLE Source Type: research
The involvement of microglia in Alzheimer's disease: a new dog in the fight.
First described clinically in 1906, Alzheimer's disease (AD) is the most common neurodegenerative disease and form of dementia worldwide. Despite its prevalence, only five therapies are currently approved for AD, all dealing with the symptoms rather than the underlying causes of the disease. A multitude of experimental evidence has suggested that the once thought inconsequential process of neuroinflammation does, in fact, contribute to the AD pathogenesis. One such central nervous system (CNS) cell type critical to this process are microglia. Plastic in nature with varied roles, microglia are emerging as key contributors t...
Source: British Journal of Pharmacology - November 16, 2018 Category: Drugs & Pharmacology Authors: Zachery Moore,
Juliet M Taylor,
Peter J Crack Tags: REVIEW ARTICLE THEMED ISSUE Source Type: research
Pharmacological modulation of mitochondrial ion channels
The field of mitochondrial ion channels has undergone a rapid development during the last three decades, due to the molecular identification of some of the channels residing in the outer and inner membranes. Relevant information about the function of these channels in physiological and pathological settings was gained thanks to genetic models for a few, mitochondria ‐specific channels. However, many ion channels have multiple localization within the cell hampering a clear‐cut determination of their function by pharmacological means. The present review summarizes our current knowledge about the ins and outs of mitochond...
Source: British Journal of Pharmacology - November 15, 2018 Category: Drugs & Pharmacology Authors: Luigi Leanza,
Vanessa Checchetto,
Lucia Biasutto,
Andrea Rossa,
Roberto Costa,
Magdalena Bachmann,
Mario Zoratti,
Ildiko Szabo Tags: REVIEW ARTICLE THEMED ISSUE Source Type: research
