Nitric oxide as a multimodal transmitter in the brain: discovery and current status
Nitric oxide (NO) operates throughout the brain as an intercellular messenger, initiating its varied physiological effects by activating specialized guanylyl cyclase ‐coupled receptors, resulting in the formation of cGMP. In line with the widespread expression of this pathway, NO participates in numerous different brain functions. This review gives an account of the discovery of NO as a signalling molecule in the brain, experiments that originated in the searc h for a mysterious cGMP‐stimulating factor released from central neurones when their NMDA receptors were stimulated, and summarises the subsequent key steps that...
Source: British Journal of Pharmacology - November 6, 2018 Category: Drugs & Pharmacology Authors: John Garthwaite Tags: REVIEW ARTICLE THEMED ISSUE Source Type: research
Nitric Oxide Synthase Enzymology in the Twenty Years After the Nobel Prize
This review briefly summarizes what was known about NO synthase (NOS) enzymology at the time of the Nobel prize award in 1998, and then discusses from the Author's perspective some of the advances in NOS enzymologic research over the subsequent twenty years, focused on five aspects: The maturation process of NOS enzymes and its regulation; the mechanism of NO synthesis; the redox roles played by the 6R ‐tetrahydrobiopterin cofactor; the role of protein conformational behavior in enabling NOS electron transfer and its regulation by NOS structural elements and calmodulin; and the catalytic cycling pathways of NOS enzymes, ...
Source: British Journal of Pharmacology - November 6, 2018 Category: Drugs & Pharmacology Authors: Dennis J Stuehr,
Mohammad Mahfuzul Haque Tags: REVIEW ARTICLE THEMED ISSUE Source Type: research
Understanding the tumour micro ‐environment communication network from an NOS2/COX2 perspective
Recent findings suggest that co ‐expression of NOS2 and COX2 is a strong prognostic indicator in triple‐negative breast cancer patients. These two key inflammation‐associated enzymes are responsible for the biosynthesis of NO and PGE2, respectively, and can exert their effect in both an autocrine and paracrine manner. Impairment of their physiological regulation leads to critical changes in both intra ‐tumoural and intercellular communication with the immune system and their adaptation to the hypoxic tumour micro‐environment. Recent studies have also established a key role of NOS2–COX2 in causing metabolic shif...
Source: British Journal of Pharmacology - November 6, 2018 Category: Drugs & Pharmacology Authors: Debashree Basudhar,
Gaurav Bharadwaj,
Veena Somasundaram,
Robert Y S Cheng,
Lisa A Ridnour,
Mayumi Fujita,
Stephen J Lockett,
Stephen K Anderson,
Daniel W McVicar,
David A Wink Tags: REVIEW ARTICLE THEMED ISSUE Source Type: research
Nociceptin/Orphanin FQ (N/OFQ) conjugated to ATTO594: a novel fluorescent probe for the N/OFQ (NOP) receptor
Conclusions and ImplicationsIn the absence of validated NOP receptor antibodies and issues surrounding the use of radiolabels (especially in low expression systems), these data indicate the utility of N/OFQATTO594 to study a wide range of N/OFQ ‐driven cellular responses. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - November 6, 2018 Category: Drugs & Pharmacology Authors: M F Bird,
R Guerrini,
J M Willets,
J P Thompson,
G Cal ó,
D G Lambert Tags: RESEARCH PAPER Source Type: research
Understanding the tumour micro ‐environment communication network from an NOS2/COX2 perspective
Recent findings suggest that co ‐expression of NOS2 and COX2 is a strong prognostic indicator in triple‐negative breast cancer patients. These two key inflammation‐associated enzymes are responsible for the biosynthesis of NO and PGE2, respectively, and can exert their effect in both an autocrine and paracrine manner. Impairment of their physiological regulation leads to critical changes in both intra ‐tumoural and intercellular communication with the immune system and their adaptation to the hypoxic tumour micro‐environment. Recent studies have also established a key role of NOS2–COX2 in causing metabolic shif...
Source: British Journal of Pharmacology - November 6, 2018 Category: Drugs & Pharmacology Authors: Debashree Basudhar,
Gaurav Bharadwaj,
Veena Somasundaram,
Robert Y S Cheng,
Lisa A Ridnour,
Mayumi Fujita,
Stephen J Lockett,
Stephen K Anderson,
Daniel W McVicar,
David A Wink Tags: REVIEW ARTICLE THEMED ISSUE Source Type: research
Nociceptin/Orphanin FQ (N/OFQ) conjugated to ATTO594: a novel fluorescent probe for the N/OFQ (NOP) receptor
Conclusions and ImplicationsIn the absence of validated NOP receptor antibodies and issues surrounding the use of radiolabels (especially in low expression systems), these data indicate the utility of N/OFQATTO594 to study a wide range of N/OFQ ‐driven cellular responses. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - November 6, 2018 Category: Drugs & Pharmacology Authors: M F Bird,
R Guerrini,
J M Willets,
J P Thompson,
G Cal ó,
D G Lambert Tags: RESEARCH PAPER Source Type: research
Nitric Oxide Synthase Enzymology in the Twenty Years After the Nobel Prize
This review briefly summarizes what was known about NO synthase (NOS) enzymology at the time of the Nobel prize award in 1998, and then discusses from the Author's perspective some of the advances in NOS enzymologic research over the subsequent twenty years, focused on five aspects: The maturation process of NOS enzymes and its regulation; the mechanism of NO synthesis; the redox roles played by the 6R ‐tetrahydrobiopterin cofactor; the role of protein conformational behavior in enabling NOS electron transfer and its regulation by NOS structural elements and calmodulin; and the catalytic cycling pathways of NOS enzymes, ...
Source: British Journal of Pharmacology - November 6, 2018 Category: Drugs & Pharmacology Authors: Dennis J Stuehr,
Mohammad Mahfuzul Haque Tags: REVIEW ARTICLE THEMED ISSUE Source Type: research
Nitric oxide as a multimodal transmitter in the brain: discovery and current status
Nitric oxide (NO) operates throughout the brain as an intercellular messenger, initiating its varied physiological effects by activating specialized guanylyl cyclase ‐coupled receptors, resulting in the formation of cGMP. In line with the widespread expression of this pathway, NO participates in numerous different brain functions. This review gives an account of the discovery of NO as a signalling molecule in the brain, experiments that originated in the searc h for a mysterious cGMP‐stimulating factor released from central neurones when their NMDA receptors were stimulated, and summarises the subsequent key steps that...
Source: British Journal of Pharmacology - November 6, 2018 Category: Drugs & Pharmacology Authors: John Garthwaite Tags: REVIEW ARTICLE THEMED ISSUE Source Type: research
Nicotinic ACh receptor α7 inhibits PDGF‐induced migration of vascular smooth muscle cells by activating mitochondrial deacetylase sirtuin 3
British Journal of Pharmacology, EarlyView. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - November 5, 2018 Category: Drugs & Pharmacology Authors: Dong ‐Jie Li,
Jie Tong,
Fei‐Yan Zeng,
Mengqi Guo,
Yong‐Hua Li,
Hongbo Wang,
Pei Wang Source Type: research
Estradiol influences on dopamine release from the nucleus accumbens shell: Sex differences and the role of selective estradiol receptor subtypes
British Journal of Pharmacology,Volume 0, Issue ja, -Not available-. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - November 1, 2018 Category: Drugs & Pharmacology Authors: Katie E Yoest,
Jennifer A Cummings,
Jill B Becker Source Type: research
Prostaglandin ‐cytokine crosstalk in chronic inflammation
British Journal of Pharmacology,Volume 0, Issue ja, -Not available-. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - November 1, 2018 Category: Drugs & Pharmacology Authors: Chengcan Yao,
Shuh Narumiya Source Type: research
Estradiol influences on dopamine release from the nucleus accumbens shell: Sex differences and the role of selective estradiol receptor subtypes
British Journal of Pharmacology,Volume 0, Issue ja, -Not available-. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - November 1, 2018 Category: Drugs & Pharmacology Authors: Katie E Yoest,
Jennifer A Cummings,
Jill B Becker Source Type: research
Prostaglandin ‐cytokine crosstalk in chronic inflammation
British Journal of Pharmacology,Volume 0, Issue ja, -Not available-. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - October 31, 2018 Category: Drugs & Pharmacology Authors: Chengcan Yao,
Shuh Narumiya Source Type: research
