Advances in Structural Biology and the Application to Biological Filament Systems
BioEssays, EarlyView. (Source: BioEssays)
Source: BioEssays - February 27, 2018 Category: Molecular Biology Source Type: research
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BioEssays, Ahead of Print. (Source: BioEssays)
Source: BioEssays - February 27, 2018 Category: Molecular Biology Source Type: research
PROTACs: An Emerging Targeting Technique for Protein Degradation in Drug Discovery
Proteolysis‐targeting chimeric molecules (PROTACs) represent an emerging technique that is receiving much attention for therapeutic intervention. The mechanism is based on the inhibition of protein function by hijacking a ubiquitin E3 ligase for protein degradation. The hetero‐bifunctional PROTACs contain a ligand for recruiting an E3 ligase, a linker, and another ligand to bind with the protein targeted for degradation. Thus, PROTACs have profound potential to eliminate “undruggable” protein targets, such as transcription factors and non‐enzymatic proteins, which are not limited to physiological substrates of th...
Source: BioEssays - February 24, 2018 Category: Molecular Biology Authors: Shanshan Gu, Danrui Cui, Xiaoyu Chen, Xiufang Xiong, Yongchao Zhao Tags: Prospects & Overviews Source Type: research
PROTACs: An Emerging Targeting Technique for Protein Degradation in Drug Discovery
BioEssays, EarlyView. (Source: BioEssays)
Source: BioEssays - February 23, 2018 Category: Molecular Biology Source Type: research
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BioEssays, Ahead of Print. (Source: BioEssays)
Source: BioEssays - February 23, 2018 Category: Molecular Biology Source Type: research
BioEssays 3 ∕2018
BioEssays,Volume 40, Issue 3, March 2018. (Source: BioEssays)
Source: BioEssays - February 21, 2018 Category: Molecular Biology Source Type: research
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BioEssays,Volume 40, Issue 3, March 2018. (Source: BioEssays)
Source: BioEssays - February 21, 2018 Category: Molecular Biology Source Type: research
BioEssays 3 ∕2018
(Source: BioEssays)
Source: BioEssays - February 21, 2018 Category: Molecular Biology Tags: Masthead Source Type: research
BioEssays 3 ∕2018
Biomolecules often undergo conformational changes, which are the driving mechanism for their molecular function. As discussed in article 1700078 by Voith von Voithenberg and Lamb, these intramolecular changes and their dynamics can be investigated using single pair Förster resonance energy transfer (spFRET). Confocal and total internal reflection fluorescence microscopy used for spFRET experiments can extract kinetic timescales of the dynamics in the range of nanoseconds to seconds. (PDB: 2YH0, 2YH1, 2KHO, 4B9Q, 1RP3, 1IW7) (Source: BioEssays)
Source: BioEssays - February 21, 2018 Category: Molecular Biology Tags: Inside Front Cover Source Type: research
BioEssays 3 ∕2018
Initial production of hydrogen peroxide (H2O2) and other reactive oxygen species was not a result of increased O2 levels in the atmosphere but rather was a crucial consequence of early Earth's weakly oxic microenvironments. However, as discussed in article 1700158 by Taverne et al., Earth's oxygen cycle did coincide with the evolution of major redox pathways (NOX, Nrf‐2 and HIF pathways) that were preserved throughout time and played a major role in Metazoan diversification and longevity. [Cover design: isontwerp.nl, Eindhoven, The Netherlands] (Source: BioEssays)
Source: BioEssays - February 21, 2018 Category: Molecular Biology Tags: Cover Picture Source Type: research
Oncogenesis as a Selective Force: Adaptive Evolution in the Face of a Transmissible Cancer
BioEssays, September 2018. (Source: BioEssays)
Source: BioEssays - February 15, 2018 Category: Molecular Biology Authors: Tracey Russell
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Thomas Madsen
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Fr édéric Thomas
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Nynke Raven
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Rodrigo Hamede
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Beata Ujvari Source Type: research
