How Polycomb ‐Mediated Cell Memory Deals With a Changing Environment
BioEssays, EarlyView. (Source: BioEssays)
Source: BioEssays - March 9, 2018 Category: Molecular Biology Source Type: research
Integrity of IKK/NF ‐κB Shields Thymic Stroma That Suppresses Susceptibility to Autoimmunity, Fungal Infection, and Carcinogenesis
BioEssays, EarlyView. (Source: BioEssays)
Source: BioEssays - March 9, 2018 Category: Molecular Biology Source Type: research
---
BioEssays, Ahead of Print. (Source: BioEssays)
Source: BioEssays - March 9, 2018 Category: Molecular Biology Source Type: research
How Polycomb ‐Mediated Cell Memory Deals With a Changing Environment
Cells and tissues are continuously exposed to a changing microenvironment, hence the necessity of a flexible modulation of gene expression that in complex organism have been achieved through specialized chromatin mechanisms. Chromatin‐based cell memory enables cells to maintain their identity by fixing lineage specific transcriptional programs, ensuring their faithful transmission through cell division; in particular PcG‐based memory system evolved to maintain the silenced state of developmental and cell cycle genes. In evolution the complexity of this system have increased, particularly in vertebrates, indicating comb...
Source: BioEssays - March 9, 2018 Category: Molecular Biology Authors: Federica Marasca, Beatrice Bodega, Valerio Orlando Tags: Prospects & Overviews Source Type: research
Integrity of IKK/NF ‐κB Shields Thymic Stroma That Suppresses Susceptibility to Autoimmunity, Fungal Infection, and Carcinogenesis
A pathogenic connection between autoreactive T cells, fungal infection, and carcinogenesis has been demonstrated in studies of human autoimmune polyendocrinopathy‐candidiasis‐ectodermal dystrophy (APECED) as well as in a mouse model in which kinase‐dead Ikkα knock‐in mice develop impaired central tolerance, autoreactive T cell–mediated autoimmunity, chronic fungal infection, and esophageal squamous cell carcinoma, which recapitulates APECED. IκB kinase α (IKKα) is one subunit of the IKK complex required for NF‐κB activation. IKK/NF‐κB is essential for central tolerance establishment by regulating the de...
Source: BioEssays - March 9, 2018 Category: Molecular Biology Authors: Feng Zhu, Yinling Hu Tags: Insights & Perspectives Source Type: research
Lipoprotein Transport: Greasing the Machines of Outer Membrane Biogenesis
BioEssays, EarlyView. (Source: BioEssays)
Source: BioEssays - March 7, 2018 Category: Molecular Biology Source Type: research
Microbial Diversity in the Eukaryotic SAR Clade: Illuminating the Darkness Between Morphology and Molecular Data
BioEssays, EarlyView. (Source: BioEssays)
Source: BioEssays - March 7, 2018 Category: Molecular Biology Source Type: research
---
BioEssays, Ahead of Print. (Source: BioEssays)
Source: BioEssays - March 7, 2018 Category: Molecular Biology Source Type: research
Microbial Diversity in the Eukaryotic SAR Clade: Illuminating the Darkness Between Morphology and Molecular Data
Despite their diversity and ecological importance, many areas of the SAR—Stramenopila, Alveolata, and Rhizaria—clade are poorly understood as the majority (90%) of SAR species lack molecular data and only 5% of species are from well‐sampled families. Here, we review and summarize the state of knowledge about the three major clades of SAR, describing the diversity within each clade and identifying synapomorphies when possible. We also assess the “dark area” of SAR: the morphologically described species that are missing molecular data. The majority of molecular data for SAR lineages are characterized from marine sa...
Source: BioEssays - March 7, 2018 Category: Molecular Biology Authors: Jean ‐David Grattepanche, Laura M. Walker, Brittany M. Ott, Daniela L. Paim Pinto, Charles F. Delwiche, Christopher E. Lane, Laura A. Katz Tags: Prospects & Overviews Source Type: research
Active Sleep Promotes Functional Connectivity in Developing Sensorimotor Networks
BioEssays, September 2018. (Source: BioEssays)
Source: BioEssays - March 6, 2018 Category: Molecular Biology Authors: Carlos Del Rio ‐Bermudez
,
Mark S. Blumberg Source Type: research
Active Sleep Promotes Functional Connectivity in Developing Sensorimotor Networks
BioEssays, EarlyView. (Source: BioEssays)
Source: BioEssays - March 6, 2018 Category: Molecular Biology Source Type: research
The Rise of the Cartwheel: Seeding the Centriole Organelle
BioEssays, EarlyView. (Source: BioEssays)
Source: BioEssays - March 6, 2018 Category: Molecular Biology Source Type: research
