Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The zinc-finger proteins WOC and ROW play distinct functions within the HP1c transcription complex
In this study we show that WOC and ROW are required for chromatin binding of both Dsk2 and HP1c. However, while impairing chromatin binding strongly destabilizes HP1c, it does not affect Dsk2 stability. We also show that WOC, but not ROW, is required for nuclear localization of Dsk2. Moreover, WOC and Dsk2 co-immunoprecitate upon ROW depletion. These results suggest that WOC and Dsk2 interact to form a subcomplex that mediates nuclear translocation of Dsk2. We also show that ROW mediates chromatin binding of the WOC/Dsk2 subcomplex, as well as of HP1c. Altogether these observations favor a model by which the interaction wi...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - January 30, 2020 Category: Genetics & Stem Cells Source Type: research

The world of asRNAs in Gram-negative and Gram-positive bacteria
Publication date: Available online 11 January 2020Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Maxence Lejars, Eliane HajnsdorfAbstractBacteria exhibit an amazing diversity of mechanisms controlling gene expression to both maintain essential functions and modulate accessory functions in response to environmental cues. Over the years, it has become clear that bacterial regulation of gene expression is still far from fully understood. This review focuses on antisense RNAs (asRNAs), a class of RNA regulators defined by their location in cis and their perfect complementarity with their tar...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - January 28, 2020 Category: Genetics & Stem Cells Source Type: research

The functional role of the C-terminal tail of the human ribosomal protein uS19
Publication date: Available online 25 January 2020Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Konstantin Bulygin, Alexey Malygin, Alexander Gopanenko, Dmitri Graifer, Galina KarpovaAbstractThe eukaryotic ribosomal protein uS19 has a C-terminal tail that is absent in its bacterial homologue. This tail has been shown to be involved in the formation of the decoding site of human ribosomes. We studied here the previously unexplored functional significance of the 15 C-terminal amino acid residues of human uS19 for the assembly of ribosomes and translation using HEK293-based cell cultures c...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - January 26, 2020 Category: Genetics & Stem Cells Source Type: research

Antisense RNA world in bacteria
Publication date: Available online 11 January 2020Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Maxence Lejars, Eliane HajnsdorfAbstractBacteria exhibit an amazing diversity of mechanisms controlling gene expression to both maintain essential functions and modulate accessory functions in response to environmental cues. Over the years, it has become clear that bacterial regulation of gene expression is still far from fully understood. This review focuses on antisense RNAs (asRNAs), a class of RNA regulators defined by their location in cis and their perfect complementarity with their tar...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - January 12, 2020 Category: Genetics & Stem Cells Source Type: research

Prion protein transcription is auto-regulated through dynamic interactions with G-quadruplex motifs in its own promoter
Publication date: Available online 10 January 2020Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Prashant Pradhan, Ankit Srivastava, Jasdeep Singh, Banhi Biswas, Akanksha Saini, Ibrar Siddique, Pooja Kumari, Md. Asim Khan, Akhilesh Mishra, Pramod Kumar Yadav, Shivani Kumar, Neel Sarovar Bhavesh, Prasanna Venkatraman, Perumal Vivekanandan, Bishwajit KunduAbstractCellular prion protein (PrP) misfolds into an aberrant and infectious scrapie form (PrPSc) that lead to fatal transmissible spongiform encephalopathies (TSEs). Association of prions with G-quadruplex (GQ) forming nucleic acid moti...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - January 11, 2020 Category: Genetics & Stem Cells Source Type: research

DEKTV and YVG motifs in the Lsm domain are important for the activity of Scd6, a conserved translation repressor protein
Publication date: Available online 9 January 2020Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Sabnam Parbin, Gayatri Mohanan, Shirish Gole, Monmita Bhar, Purusharth I. RajyaguruAbstractScd6 is a conserved RGG-motif protein which represses translation by binding eIF4G through its RGG-motif. Lsm and FDF are two other conserved domains present in the protein, however the role of both these domains is unclear. We provide evidence in this report that the Lsm domain is important for the role of Scd6 in translation. Mutant of Scd6 lacking the Lsm domain does not cause overexpression growth de...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - January 11, 2020 Category: Genetics & Stem Cells Source Type: research

Editorial Board
Publication date: January 2020Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, Volume 1863, Issue 1Author(s): (Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms)
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - January 9, 2020 Category: Genetics & Stem Cells Source Type: research

Activating transcription factor 6 (ATF6) negatively regulates Polo-like kinase 4 expression via recruiting C/EBPβ to the upstream-promoter during ER stress
Publication date: Available online 9 January 2020Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Tao Shen, Yan Li, Zhiguang Chen, Shuang Liang, Yu Qiu, Lin Zhu, Gen Ba, Guangwei Lu, Lian QiuAbstractPolo-like kinase 4 (PLK4) is a member of the serine/threonine protein kinase family involved in cell-cycle regulation and cellular response to stresses. However, the alteration of PLK4 in response to endoplasmic reticulum (ER) stress has not been well described. In the present study, we focused on the regulation of PLK4 regulation in response to ER stress. PLK4 expression was dramatically reduc...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - January 9, 2020 Category: Genetics & Stem Cells Source Type: research

Molecular mechanisms underlying eicosapentaenoic acid inhibition of HDAC1 and DNMT expression and activity in carcinoma cells
Publication date: Available online 8 January 2020Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Veronica Ceccarelli, Simona Ronchetti, Maria Cristina Marchetti, Mario Calvitti, Carlo Riccardi, Francesco Grignani, Alba VecchiniAbstractDNA methylation and histone acetylation, the most studied epigenetic changes, drive and maintain cancer phenotypes. DNA methyltransferase (DNMT) dysregulation promoted localized hypermethylation in CpG rich regions while upregulated histone deacetylases (HDAC) deacetylated histone tails. Both changes led to close chromatin conformation, suppressing transcrip...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - January 8, 2020 Category: Genetics & Stem Cells Source Type: research

URH49 exports mRNA by remodeling complex formation and mediating the NXF1-dependent pathway
Publication date: Available online 7 January 2020Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Ken-ichi Fujita, Tomohiro Yamazaki, Kotaro Harada, Shigeto Seno, Hideo Matsuda, Seiji MasudaAbstractThe TREX complex integrates information from nuclear mRNA processing events to ensure the timely export of mRNA to the cytoplasm. In humans, UAP56 and its paralog URH49 form distinct complexes, the TREX complex and the AREX complex, respectively, which cooperatively regulate the expression of a specific set of mRNA species on a genome wide scale. The difference in the complex formation between U...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - January 8, 2020 Category: Genetics & Stem Cells Source Type: research

G-quadruplex deconvolution with physiological mimicry enhances primary screening: Optimizing the FRET Melt2 assay
Publication date: Available online 28 December 2019Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Rhianna K. Morgan, Alexandra Psaras, Quinea Lassiter, Kelsey Raymer, Tracy A. BrooksAbstractNon-B-DNA G-quadruplex (G4) structures have shown promise as molecular targets. Modulating G4 stability for oncogenic transcriptional control is a promising avenue for the development of novel therapeutics. Extracellularly, G4 stabilization can be mediated by alkali cations, modifying water content, or with molecular crowding. Intracellularly, G4 formation is mediated by negative superhelicity and tra...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - December 30, 2019 Category: Genetics & Stem Cells Source Type: research

Regulatory RNA at the crossroads of carbon and nitrogen metabolism in photosynthetic cyanobacteria
Publication date: Available online 26 December 2019Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Alicia M. Muro-Pastor, Wolfgang R. HessAbstractCyanobacteria are photosynthetic bacteria that populate widely different habitats. Accordingly, cyanobacteria exhibit a wide spectrum of lifestyles, physiologies, and morphologies and possess genome sizes and gene numbers which may vary by up to a factor of ten within the phylum. Consequently, large differences exist between individual species in the size and complexity of their regulatory networks. Several non-coding RNAs have been identified t...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - December 26, 2019 Category: Genetics & Stem Cells Source Type: research

Glucocorticoids uncover a critical role for ASH2L on BCL-X expression regulation in leukemia cells
We report here that the trithorax protein ASH2L, considered one of the core subunits of H3K4-specific MLL/SET methyltransferase complexes, contributes to anti-apoptotic BCL-XL over-expression and cell survival in patient-derived myeloid leukemia cells. We find that the unliganded glucocorticoid receptor (uGR) and ASH2L interact in a common protein complex through a chromatin looping determined by uGR and ASH2L binding to BCL2L1 specific +58 HRE and promoter region, respectively. Upon addition of dexamethasone, GR and ASH2L recruitment is reduced, BCL-XL expression diminishes and apoptosis is induced consequently. Overall, ...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - December 21, 2019 Category: Genetics & Stem Cells Source Type: research

Profiling torpor-responsive microRNAs in muscles of the hibernating primate Microcebus murinus
This study identifies unique miRNA signatures and ‘biomarkers of torpor’ that provide us with primate-specific insights on torpor at high body temperatures that can be exploited for human biomedical concerns.Graphical abstract (Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms)
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - December 11, 2019 Category: Genetics & Stem Cells Source Type: research

Which came first, the transcriptional regulator or its target genes? An evolutionary perspective into the construction of eukaryotic regulons
This article is part of a Special Issue entitled: Transcriptional Profiles and Regulatory Gene Networks edited by Dr. Dr. Federico Manuel Giorgi and Dr. Shaun Mahony. (Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms)
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - December 9, 2019 Category: Genetics & Stem Cells Source Type: research