Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Specificity of MLL1 and TET3 CXXC domains towards naturally occurring cytosine modifications
Publication date: Available online 22 October 2018Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Anna Stroynowska-Czerwińska, Anna Piasecka, Matthias BochtlerAbstractCXXC domains have traditionally been considered as CpG specific DNA binding domains that are repelled by cytosine modifications. This view has recently been challenged by the demonstration that CXXC domain of TET3 has relaxed sequence specificity and binds with the highest affinity to symmetric DNA duplex containing 5caCpG. Here, we present a comparative analysis of the MLL1-CXXC and TET3-CXXC sequence specificity and toler...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - October 22, 2018 Category: Genetics & Stem Cells Source Type: research

Repression of yeast RNA polymerase III by stress leads to degradation of its largest subunit, C160
Publication date: Available online 19 October 2018Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Ewa Leśniewska, Małgorzata Cieśla, Magdalena BogutaAbstractRespiratory growth and various stress conditions repress RNA polymerase III (Pol III) transcription in Saccharomyces cerevisiae. Here we report a degradation of the largest Pol III catalytic subunit, C160 as a consequence of Pol III transcription repression. We observed C160 degradation in response to transfer of yeast from fermentation to respiration conditions, as well as treatment with rapamycin or inhibition of nucleotide biosy...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - October 20, 2018 Category: Genetics & Stem Cells Source Type: research

m6A-mediated translation regulation
Publication date: Available online 17 October 2018Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Kate D. Meyer (Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms)
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - October 18, 2018 Category: Genetics & Stem Cells Source Type: research

Editorial Board
Publication date: November 2018Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, Volume 1861, Issue 11Author(s): (Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms)
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - October 18, 2018 Category: Genetics & Stem Cells Source Type: research

DNA Demethylation by DNMT3A and DNMT3B in vitro and of Methylated Episomal DNA in Transiently Transfected Cells
In this study, we have used LC-MS/MS to track down the fate of the methyl group removed from 5mC on DNA by mouse DNMT3B in vitro and found that it becomes covalently linked to the DNA methylation catalytic cysteine of the enzyme. We also show that Ca2+ homeostasis-dependent but TET1/TET2/TET3/TDG-independent demethylation of methylated episomal DNA by mouse DNMT3A or DNMT3B can occur in transfected human HEK 293 and mouse embryonic stem (ES) cells. Based on these results, we present a tentative working model of Ca2+ and redox conditions-dependent active DNA demethylation by DNMTs. Our study substantiates the potential role...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - October 17, 2018 Category: Genetics & Stem Cells Source Type: research

Human ALKBH3-induced m1A demethylation increases the CSF-1 mRNA stability in breast and ovarian cancer cells
Publication date: Available online 17 October 2018Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Ho-Hyung Woo, Setsuko K. ChambersAbstractIn ovarian and breast cancers, the actions of the cytokine CSF-1 lead to poor prognosis. CSF-1 expression can be regulated post-transcriptionally. RNA methylation is another layer of posttranscriptional regulation. The methylation of N1 atom of adenine (m1A) results in a conformational change of RNA which regulates translational efficiency. Our study indicates that the m1A is also involved in the CSF-1 mRNA decay. The alteration of ALKBH3 expression, a...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - October 17, 2018 Category: Genetics & Stem Cells Source Type: research

Regulation of ATM and ATR by SMARCAL1 and BRG1
Publication date: Available online 11 October 2018Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Ramesh Sethy, Radhakrishnan Rakesh, Ketki Patne, Vijendra Arya, Tapan Sharma, Dominic Thangminlen Haokip, Reshma Kumari, Rohini MuthuswamiAbstractThe G2/M checkpoint is activated on DNA damage by the ATM and ATR kinases that are regulated by post-translational modifications. In this paper, the transcriptional co-regulation of ATM and ATR by SMARCAL1 and BRG1, both members of the ATP-dependent chromatin remodeling protein family, is described. SMARCAL1 and BRG1 co-localize on the promoters of ...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - October 12, 2018 Category: Genetics & Stem Cells Source Type: research

Angiotensin II induced CSF1 transcription is mediated by a crosstalk between different epigenetic factors in vascular endothelial cells
In conclusion, our data unveil a novel epigenetic mechanism whereby a BRG1-centered complex mediates transcriptional activation of CSF1 by Ang II in vascular endothelial cells. (Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms)
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - October 12, 2018 Category: Genetics & Stem Cells Source Type: research

The expression of CKLFSF2B is regulated by GATA1 and CREB in the Leydig cells, which modulates testicular steroidogenesis
Publication date: Available online 12 October 2018Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Sudeep Kumar, Hana Kang, Eunsook Park, Hee-Sae Park, Keesook LeeAbstractCKLFSF is a protein family that serves as a functional bridge between chemokines and members of the transmembrane 4 superfamily (TM4SF). In the course of evolution, CKLFSF2 has evolved as two isoforms, namely CKLFSF2A and CKLFSF2B, in mice. CKLFSF2A, also known as CMTM2A and ARR19, is expressed in the testis and is important for testicular steroidogenesis. CKLFSF2B is also known to be highly expressed in the testis. In th...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - October 12, 2018 Category: Genetics & Stem Cells Source Type: research

mRNA cap regulation in mammalian cell function and fate
This article is part of a Special Issue entitled: mRNA modifications in gene expression control edited by Dr. Soller Matthias and Dr. Fray Rupert. (Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms)
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - October 10, 2018 Category: Genetics & Stem Cells Source Type: research

Myt1 and Myt1l transcription factors limit proliferation in GBM cells by repressing YAP1 expression
Publication date: Available online 10 October 2018Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Tiffany A. Melhuish, Izabela Kowalczyk, Arkadi Manukyan, Ying Zhang, Anant Shah, Roger Abounader, David WottonAbstractMyelin transcription factor 1 (Myt1) and Myt1l (Myt1-like) are zinc finger transcription factors that regulate neuronal differentiation. Reduced Myt1l expression has been implicated in glioblastoma (GBM), and the related St18 was originally identified as a potential tumor suppressor for breast cancer. We previously analyzed changes in gene expression in a human GBM cell line w...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - October 10, 2018 Category: Genetics & Stem Cells Source Type: research

Heterogeneous ribonucleoprotein F regulates YAP expression via a G-tract in 3′UTR
Publication date: Available online 10 October 2018Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Wing-Keung Chu, Li-Man Hung, Chun-Wei Hou, Jan-Kan ChenAbstractThe Yes-associated protein (YAP) is a transcription coactivator that plays crucial roles in organ size control and tumorigenesis, and was demonstrated to be inhibited by the Hippo signaling pathway. To date, the molecular mechanisms regulating the expression of YAP in human cells remain unknown. In the present study, we found that hnRNP F and hnRNP U negatively regulate YAP expression. We also showed that downregulation of YAP exp...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - October 10, 2018 Category: Genetics & Stem Cells Source Type: research

Active DNA demethylation by DNMT3A and DNMT3B in vitro and of methylated episomal DNA in transiently transfected cells
In this study, we have used LC-MS/MS to track down the fate of the methyl group removed from 5mC on DNA by mouse DNMT3B in vitro and found that it becomes covalently linked to the DNA methylation catalytic cysteine of the enzyme. We also show that Ca2+ homeostasis-dependent but TET1/TET2/TET3/TDG-independent demethylation of methylated episomal DNA by mouse DNMT3A or DNMT3B can occur in transfected human HEK 293 and mouse embryonic stem (ES) cells. Based on these results, we present a tentative working model of Ca2+ and redox conditions-dependent active DNA demethylation by DNMTs. Our study substantiates the potential role...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - October 9, 2018 Category: Genetics & Stem Cells Source Type: research

It's complicated… m6A-dependent regulation of gene expression in cancer
Publication date: Available online 5 October 2018Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Christina M. Fitzsimmons, Pedro J. BatistaAbstractCellular function relies on multiple pathways that are coordinated to ensure the proper execution of gene expression networks. Failure to coordinate the multiple programs active in the cell can have catastrophic consequences and lead to diseases such as cancer. At the post-transcriptional level, RNA modifications play important roles in the regulation of gene expression. N6-methyladenosine (m6A) is the most abundant internal messenger RNA (mRNA...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - October 6, 2018 Category: Genetics & Stem Cells Source Type: research

Editorial Board
Publication date: October 2018Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, Volume 1861, Issue 10Author(s): (Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms)
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - October 5, 2018 Category: Genetics & Stem Cells Source Type: research