Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Epigenetic regulation of carnitine palmitoyltransferase 1 (Cpt1a) by high fat diet
The objective of this study was to uncover how diet mediates the transcriptional regulation of Cpt1a. Pregnant Sprague Dawley rats were exposed to either a high-fat (HF) or low-fat control diet during gestation and lactation. At weaning, male offspring received either a HF or control diet, creating 4 groups: lifelong control diet (C/C; n = 12), perinatal HF diet (HF/C; n = 9), post-weaning HF diet (C/HF; n = 10), and lifelong HF diet (HF/HF; n = 10). Only HF/HF animals had higher hepatic Cpt1a mRNA expression than C/C. Epigenetic analysis revealed reduced DNA methylation (DNAMe) and increased histone 3 lysi...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - December 31, 2018 Category: Genetics & Stem Cells Source Type: research

Role of long non-coding RNAs in metabolic control
This article is part of a Special Issue entitled: ncRNA in control of gene expression edited by Kotb Abdelmohsen. (Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms)
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - December 27, 2018 Category: Genetics & Stem Cells Source Type: research

Post-transcriptional regulation by cytosine-5 methylation of RNA
Publication date: Available online 27 December 2018Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Raquel García-Vílchez, Ana Sevilla, Sandra BlancoAbstractThe recent advent of high-throughput sequencing technologies coupled with RNA modifications detection methods has allowed the detection of RNA modifications at single nucleotide resolution giving a more comprehensive landscape of post-transcriptional gene regulation pathways. In this review, we focus on the occurrence of 5-methylcytosine (m5C) in the transcriptome. We summarise the main findings of the molecular role in post-transcri...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - December 27, 2018 Category: Genetics & Stem Cells Source Type: research

Reviewer Acknowledgement list
Publication date: January 2019Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, Volume 1862, Issue 1Author(s): (Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms)
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - December 27, 2018 Category: Genetics & Stem Cells Source Type: research

Editorial Board
Publication date: January 2019Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, Volume 1862, Issue 1Author(s): (Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms)
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - December 27, 2018 Category: Genetics & Stem Cells Source Type: research

The synergy between RSC, Nap1 and adjacent nucleosome in nucleosome remodeling
Publication date: Available online 26 December 2018Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Kuan-Wei Hsu, Sih-Yao Chow, Bo-Yu Su, Yi-Han Lu, Cyuan-Ji Chen, Wen-Ling Chen, Ming-Yuan Cheng, Hsiu-Fang FanAbstractEukaryotes have evolved a specific strategy to package DNA. The nucleosome is a 147-base-pair DNA segment wrapped around histone core proteins that plays important roles regulating DNA-dependent biosynthesis and gene expression. Chromatin remodeling complexes (RSC, Remodel the Structure of Chromatin) hydrolyze ATP to perturb DNA-histone contacts, leading to nucleosome sliding ...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - December 26, 2018 Category: Genetics & Stem Cells Source Type: research

RNA ribose methylation (2′-O-methylation): Occurrence, biosynthesis and biological functions
Publication date: Available online 17 December 2018Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Lilia Ayadi, Adeline Galvanin, Florian Pichot, Virginie Marchand, Yuri MotorinAbstractMethylation of riboses at 2′-OH group is one of the most common RNA modifications found in number of cellular RNAs from almost any species which belong to all three life domains. This modification was extensively studied for decades in rRNAs and tRNAs, but recent data revealed the presence of 2′-O-methyl groups also in low abundant RNAs, like mRNAs.Ribose methylation is formed in RNA by two alternative ...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - December 18, 2018 Category: Genetics & Stem Cells Source Type: research

Regulation of asymmetries in the kinetics and protein numbers of bacterial gene expression
Publication date: Available online 14 December 2018Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Sofia Startceva, Vinodh K. Kandavalli, Ari Visa, Andre S. RibeiroAbstractGenetic circuits change the status quo of cellular processes when their protein numbers cross thresholds. We investigate the regulation of RNA and protein threshold crossing propensities in Escherichia coli. From in vivo single RNA time-lapse microscopy data from multiple promoters, mutants, induction schemes and media, we study the asymmetry and tailedness (quantified by the skewness and kurtosis, respectively) of the ...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - December 15, 2018 Category: Genetics & Stem Cells Source Type: research

m6A modification of non-coding RNA and the control of mammalian gene expression
This article is part of a Special Issue entitled: mRNA modifications in gene expression control edited by Dr. Soller Matthias and Dr. Fray Rupert. (Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms)
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - December 12, 2018 Category: Genetics & Stem Cells Source Type: research

Modulation of vitamin D signaling by the pioneer factor CEBPA
In conclusion, CEBPA supports vitamin D signaling concerning actions of the innate immune system, but uses the antagonism with PU.1 for suppressing possible overreactions of adaptive immunity. (Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms)
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - December 11, 2018 Category: Genetics & Stem Cells Source Type: research

The role of RNA adenosine demethylases in the control of gene expression
This article is part of a Special Issue entitled: mRNA modifications in gene expression control edited by Dr. Soller Matthias and Dr. Fray Rupert. (Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms)
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - December 11, 2018 Category: Genetics & Stem Cells Source Type: research

The mammalian mitochondrial epitranscriptome
This article is part of a Special Issue entitled: mRNA modifications in gene expression control edited by Dr. Soller Matthias and Dr. Fray Rupert. (Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms)
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - December 5, 2018 Category: Genetics & Stem Cells Source Type: research

The emerging impact of tRNA modifications in the brain and nervous system
This article is part of a Special Issue entitled: mRNA modifications in gene expression control edited by Dr. Soller Matthias and Dr. Fray Rupert. (Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms)
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - December 5, 2018 Category: Genetics & Stem Cells Source Type: research

A positive feedback regulation of Heme oxygenase 1 by CELF1 in cardiac myoblast cells
Publication date: Available online 30 November 2018Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Yang Liu, Huiwen Wang, Jun Wang, Bin Wei, Xinyi Zhang, Mengqi Zhang, Dong Cao, Jiang Dai, Zhen Wang, Eric Nyirimigabo, Guangju JiAbstractAs an RNA binding protein, CUG-BP Elav-like family (CELF) has been shown to be critical for heart biological functions. However, no reports have revealed the function of CELF1 in hypertrophic cardiomyopathy (HCM). Hinted by RNA immunoprecipitation-sequencing (RIP-seq) data, the influence of the CELF protein on heme oxygenase-1 (HO-1) expression was tested b...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - December 1, 2018 Category: Genetics & Stem Cells Source Type: research

Coregulatory long non-coding RNA and protein-coding genes in serum starved cells
Publication date: Available online 29 November 2018Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Fan Wang, Rui Liang, Benjamin Soibam, Jin Yang, Yu LiuAbstractSerum starvation is widely used in cell biology to trigger cell cycle arrest, apoptosis, autophagy, and metabolic adaptations. Serum starvation-related molecular events have been well characterized at protein level but not at transcript level: how long non-coding RNAs contribute to the regulation of protein-coding genes is largely unknown. Here, we captured the lncRNA transcriptome in serum starved mouse embryonic fibroblasts and ...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - November 30, 2018 Category: Genetics & Stem Cells Source Type: research