Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The m6A‑methylase complex and mRNA export
Publication date: Available online 2 October 2018Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Simon Lesbirel, Stuart A. WilsonAbstractDuring synthesis, mRNA undergoes a number of modifications such as capping, splicing and polyadenylation. These processes are coupled with the orderly deposition of the TREX complex on the mRNA and subsequent recruitment of the NXF1-P15 heterodimer which stimulates the nuclear export of mature mRNAs. mRNAs also undergo a number of internal modifications, the most common of which is the N6‑methyladenosine (m6A) modification. In this review we discuss th...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - October 5, 2018 Category: Genetics & Stem Cells Source Type: research

Transcription factor Zbtb38 downregulates the expression of anti-inflammatory IL1r2 in mouse model of rheumatoid arthritis
Publication date: Available online 15 September 2018Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Tímea Ocskó, Dániel M. Tóth, Gyula Hoffmann, Vilmos Tubak, Tibor T. Glant, Tibor A. RauchAbstractDNA methylation is a decisive regulator of gene expression. Differentially methylated promoters were described in rheumatoid arthritis (RA), but we do not know how these epimutations can trigger a proinflammatory cytokine milieu. B cell-focused DNA methylome studies identified a group of genes that had undergone disease-associated changes in a murine model of RA. An arthritis-specific epimut...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - September 17, 2018 Category: Genetics & Stem Cells Source Type: research

G-quadruplex structures at the promoter of HOXC10 regulate its expression
In this report, we revealed that the HOXC10 promoter contains multiple G-tracts in its negative strand and has high potential of forming G-quadruplex structures. In circular dichroism studies, synthesized oligonucleotides based on the G-rich region of 241–297 base pairs upstream of the HOXC10 transcription start site showed molar ellipticity at specific wavelengths characteristic of G-quadruplex structures. Analyses of these oligonucleotides by native polyacrylamide gel electrophoresis, gel-shift assay, immunostaining and replication stop assay revealed formation of multiple types of G-quadruplex structures in presence o...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - September 15, 2018 Category: Genetics & Stem Cells Source Type: research

Pro-inflammatory cytokines IL-6 and CCL2 suppress expression of circadian gene Period2 in mammary epithelial cells
Publication date: Available online 13 September 2018Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Chan-Wei Yu, Kuo-Chih Cheng, Ling-Chih Chen, Meng-Xuan Lin, Yi-Cheng Chang, Wendy W. Hwang-VersluesAbstractChronic inflammation is known to contribute to tumor initiation and cancer progression. In breast tissue, the core circadian gene Period (PER)2 plays a critical role in mammary gland development and possesses tumor suppressor function. Interleukin (IL)-6 and C-C motif chemokine ligand (CCL) 2 are among the most abundant cytokines in the inflammatory microenvironment. We found that acut...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - September 15, 2018 Category: Genetics & Stem Cells Source Type: research

Comprehensive analysis of chromatin signature and transcriptome uncovers functional lncRNAs expressed in nephron progenitor cells
In conclusion, we identified a lncRNA, Gm29418, in nephron progenitor cells that has an enhancer-like function on a key regulatory gene, Six2. (Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms)
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - September 15, 2018 Category: Genetics & Stem Cells Source Type: research