THERAPIES FOR CROHN'S DISEASE: a clinical update
ABSTRACT The main objectives of clinical therapy in Crohn's disease are clinical and endoscopic remission without the use of corticosteroids for long periods of time, prevention of hospitalization and surgery, and improvement of quality of life. The main limitation of drug therapy is the loss of response over the long term, which makes incorporation of new drugs to the therapeutic arsenal necessary. This review analyses the main drugs currently used in clinical treatment of Crohn's disease.RESUMO Os principais objetivos da terapia clínica na doença de Crohn são a remissão clínica e endoscópica por tempo prolongado, s...
Source: Arquivos de Gastroenterologia - July 19, 2016 Category: Gastroenterology Source Type: research
RELIABILITY OF THE FATIGUE SEVERITY SCALE IN CIRRHOTIC AND CORRELATION WITH DEPRESSION AND QUALITY OF LIFE: preliminary assessment
Conclusion The Fatigue Severity Scale showed satisfactory reliability in evaluation of fatigue in cirrhotic and can be used as a tool for this purpose. Fatigue is related to depression and quality of life in the physical aspects domains, pain, general health and social aspects.RESUMO Contexto A fadiga é uma queixa comum em indivíduos com doença hepática e pode ser considerado um sintoma incapacitante, afetando sua qualidade de vida e saúde mental. A versão brasileira da Fatigue Severity Scale mostrou sensibilidade para avaliar a fadiga em algumas populações, mas ainda não foi testada no indivíduo cirrótico. Ob...
Source: Arquivos de Gastroenterologia - July 19, 2016 Category: Gastroenterology Source Type: research
SAFETY OF MANNITOL USE IN BOWEL PREPARATION: a prospective assessment of intestinal methane (CH4) levels during colonoscopy after mannitol and sodium phosphate (NaP) bowel cleansing
Conclusion - This is the largest study to assess the safety of mannitol for bowel preparation, considering methane measurements. Our results indicate that mannitol use is as safe as NaP, and gas exchange was efficient in reducing methane concentrations.RESUMO Contexto - Preparo adequado é fundamental para garantia de boa qualidade em colonoscopia. Apesar de relatos de explosão do cólon durante colonoscopia, secundários à produção de metano e hidrogênio pela fermentação bacteriana, acredita-se que a troca gasosa durante o procedimento diminua a concentração existente de metano, permitindo a utilização com s...
Source: Arquivos de Gastroenterologia - July 19, 2016 Category: Gastroenterology Source Type: research
ENDOSCOPIC GASTRIC SUBMUCOSAL DISSECTION: experimental comparative protocol between standard technique and Hybrid-Knife(r)
Conclusion - The hybrid-knife technique is an acceptable alternative to submucosal dissection, showing no difference compared to the standard technique taking into consideration the procedure, the presence of complications and the quality of the resected specimen.RESUMO Contexto O tratamento endoscópico de tumores gastrointestinais superficiais é realizado rotineiramente, no entanto as vantagens e deficiências da dissecção submucosa com jato de pressão ainda é debatido. Objetivo - Visando comparar esta técnica com dissecção submucosa convencional, um estudo foi realizado em suínos. Métodos - Áreas da muco...
Source: Arquivos de Gastroenterologia - July 19, 2016 Category: Gastroenterology Source Type: research
SEQUENCE SIMILARITY BETWEEN THYROID SELF-PROTEIN AND HEPATITIS C VIRUS POLYPROTEIN: possible triggering mechanism of autoimmune thyroiditis
Conclusion - Bioinformatics data, suggest a possible pathogenic link between hepatitis C virus and autoimmune thyroid disease. Through of molecular mimicry is observed that sequences similarities between viral polyproteins and self-proteins thyroid could be a mechanism of induction of crossover immune response to self-antigens, with a breakdown of self-tolerance, resulting in autoimmune thyroid disease.RESUMO Contexto - A exposição a antígenos virais que compartilham sequência de aminoácidos semelhantes a auto-antígenos pode provocar doenças auto-imunes em indivíduos predispostos geneticamente, e a teoria do mim...
Source: Arquivos de Gastroenterologia - July 19, 2016 Category: Gastroenterology Source Type: research
Hiv and hepatitis c virus coinfection. who is this patient today?
Conclusion - Clinicians should recognize that coinfected and monoinfected individuals are different groups regarding the traditional and HIV-related risk factors and should be managed and screened individually in order to prevent cardiovascular and renal complications.RESUMO Contexto - O aumento da sobrevida após a introdução da terapia antirretroviral nos pacientes vivendo com HIV tem como consequência o aparecimento de doenças emergentes nestes pacientes, como a hepatite pelo vírus C, doenças renais e cardiovasculares. Objetivo - O presente estudo tem como objetivo investigar as diferenças entre monoinfectad...
Source: Arquivos de Gastroenterologia - July 19, 2016 Category: Gastroenterology Source Type: research
Prevalence of occult hepatitis b infection in iranian cancer patients before chemotherapy treatment
Conclusion Screening of occult HBV infection by HBsAg, HBV DNA and anti HB core antibody should be suggested as a routine investigation in cancer patients before receiving chemotherapy.RESUMO Contexto A infecção oculta da hepatite B caracteriza-se por antígeno de superfície da hepatite B (AgHBs) negativo com vírus detectável da hepatite B (HBV) -DNA, com ou sem anticorpo de núcleo da hepatite B (anti-HBc). A reativação do HBV em indivíduos sob terapia imunossupressora é crítica, originando a infecção oculta pelo VHB. Objetivo Este estudo teve como objetivo determinar a prevalência de infecção oculta pelo...
Source: Arquivos de Gastroenterologia - July 19, 2016 Category: Gastroenterology Source Type: research
IS RESECTION OF HEPATOCELLULAR CARCINOMA IN THE ERA OF LIVER TRANSPLANTATION WORTHWILE? A single center experience
Conclusion - Resection, for selected cases, is a potentially curative treatment with acceptable morbidity and mortality and, in a context of a long waiting list for transplant, plays an important role for the treatment of hepatocellular carcinoma.RESUMO Contexto - A ressecção do carcinoma hepatocelular é um procedimento terapêutico potencialmente curativo que pode ser realizado imediatamente após sua indicação, sem a necessidade de longo tempo de espera e com custos mais baixos quando comparado com o transplante hepático, sendo uma boa alternativa em pacientes com função hepática preservada. Objetivo - Aval...
Source: Arquivos de Gastroenterologia - July 19, 2016 Category: Gastroenterology Source Type: research
NEOADJUVANT THERAPY AND SURGERY FOR RECTAL CANCER. Comparative study between partial and complete pathological response
Conclusion In this study, the only factor associated with complete remission of rectal adenocarcinoma was the time between neoadjuvant therapy and surgery. This group of patients had less affected lymph nodes, less angiolymphatic and perineural involvement, a longer overall and disease-free survival, but no significant statistical difference was observed in local recurrence and distant metastasis. Although the complete pathologic remission was associated with better prognosis, this not implied in the cure of the disease for all patients.RESUMO Contexto A abordagem do câncer retal extra-peritoneal localmente avançado imp...
Source: Arquivos de Gastroenterologia - July 19, 2016 Category: Gastroenterology Source Type: research
Microbiological analysis of bile in patients with benign and malignant biliopancreatic diseases and its consequences
Conclusion Bactibilia was found in 12 samples and Escherichia coli and Klebsiella sp were most often identified in patients with benign diseases, as well as Streptococcus sp and Klebsiella sp in cancer patients. There was a trend of higher postoperative infectious complication incidence in patients with bactibilia.RESUMO Contexto Bacteriobilia pode produzir várias consequências para a saúde humana. Objetivo Avaliar a microbiologia da bile de pacientes com doenças biliopancreáticas para identificar bactérias e possíveis consequências. Métodos Estudo retrospectivo microbiológico. Trinta amostras de bile de paci...
Source: Arquivos de Gastroenterologia - July 19, 2016 Category: Gastroenterology Source Type: research
Recurrence rate of helicobacter pylori in patients with peptic ulcer five years or more after successful eradication
Conclusion The recurrence of H. pylori in patients with peptic ulcer can occur in the long-term - even if the infection had been successfully eradicated and the patients had remained free of recurrence in the first years of follow-up.RESUMO Contexto A infecção por Helicobacter pylori é altamente prevalente no mundo, especialmente nos países em desenvolvimento, e sua presença na mucosa gastroduodenal está associada com o desenvolvimento de úlcera péptica e outras patologias. A erradicação do H. pylori melhora a histologia da mucosa em pacientes com úlcera péptica. Objetivo Determinar se a recorrência da infec...
Source: Arquivos de Gastroenterologia - July 19, 2016 Category: Gastroenterology Source Type: research
Translation and validation of the brazilian portuguese version of the gastrointestinal symptom rating scale (gsrs) questionnaire
Conclusion - The GSRS was translated and validated into Brazilian Portuguese, with appropriate internal consistency and reliability and is available to be used in assessments of bowel function.RESUMO Contexto - O funcionamento intestinal é um dos parâmetros amplamente avaliado em estudos intervencionais e longitudinais, pois está associado à manutenção da saúde. A avaliação do funcionamento intestinal tem sido realizada por diferentes questionários, mas são poucas as alternativas validadas em português. Objetivo - O objetivo deste trabalho foi traduzir e validar para a língua portuguesa (Brasil) o questio...
Source: Arquivos de Gastroenterologia - July 19, 2016 Category: Gastroenterology Source Type: research
Reliability of barr, leech, and blethyn score in using of plain radiography in determining fecal impaction in children with and without constipation
Conclusion - Barr, Blethyn and Leech scores were significantly higher in children with abdominal pain and constipation in contrast to children with abdominal pain and without constipation. Sensitivity of Leech score was more than Barr and Blethyn scoring systems. Specificity of Blethyn score was more than Barr and Leech score.RESUMO Contexto - Diversos métodos de pontuação utilizando a radiografia simples foram desenvolvidos para a avaliação de retenção fecal em crianças. Há controvérsias sobre a especificidade e sensibilidade destes sistemas de pontuação. Objetivo - O objetivo deste estudo foi avaliar os ...
Source: Arquivos de Gastroenterologia - July 19, 2016 Category: Gastroenterology Source Type: research
Videofluoroscopic evaluation of swallows in anorexia nervosa
Conclusion There seems to be no important alterations of swallowing in subjects with anorexia nervosa, although the results suggest that pharyngeal transit has shorter duration than that seen in healthy volunteers and the hyoid movement duration is longer in patients than in healthy volunteers. Fast pharyngeal transit may be the cause of bolus transit perception in patients with anorexia nervosa.RESUMO Contexto Existem alguns estudos na literatura sobre o comportamento alimentar e da mastigação em pacientes com distúrbios da alimentação, no entanto não é conhecido se há alterações na dinâmica da deglutição e...
Source: Arquivos de Gastroenterologia - July 19, 2016 Category: Gastroenterology Source Type: research
Combined 24-hours esophageal ph monitoring and multichannel intraluminal impedance for comparison of gastroesophageal reflux in children with typical versus atypical symptoms of gastroesophageal reflux disease
Conclusion - Symptom index was significantly higher in atypical symptoms compared to typical symptoms. Higher number of acid reflux was found in children with atypical symptoms of reflux. Longer duration of bolus clearance was found in group with atypical symptoms of reflux.RESUMO Contexto - O refluxo gastroesofágico é a doença esofágica mais comum em Pediatria. Objetivo - O objetivo deste estudo foi comparar parâmetros de refluxo em pacientes com sintomas típicos e atípicos de refluxo gastroesofágico na população pediátrica usando impedância intraluminal multicanal e monitoramento 24 horas do pH esofágic...
Source: Arquivos de Gastroenterologia - July 19, 2016 Category: Gastroenterology Source Type: research
