Hepatitis B status in hemodialysis patients
CONCLUSION: Despite the benefit of dosing of anti-HBc and anti-HBs before admission to dialysis, economic constraints have reduced the screening to only HBsAg. Since occult HBV infection has already been demonstrated in hemodialysis patients, the measure of anti-HBc should be encouraged.RESUMO CONTEXTO: Pacientes cronicamente em di álise apresentam alta prevalência de infecção por vírus da hepatite B. Apesar de práticas de controle de infecção, vigilância de marcadores sorológicos e vacinação contra a hepatite B, ainda há surtos da doença em centros de diálise. OBJETIVO: Este estudo tem como objetivo aval...
Source: Arquivos de Gastroenterologia - November 9, 2017 Category: Gastroenterology Source Type: research
Variceal bleeding: update of recommendations from the brazilian association of hepatology
ABSTRACT Since the publication of the Brazilian Association of Hepatology recommendations for the prevention and treatment of variceal bleeding in 2010, new evidence-based data were reported in the literature. This has changed our current management for portal hypertension. This review updates the previous recommendations. It takes the new prognostic staging of cirrhosis into account allowing tailored treatment for advanced fibrosis, compensated or decompensated cirrhosis. An organizing panel of five experts reviewed all recommendations according to available data, which were subsequently scrutinized by all members of the ...
Source: Arquivos de Gastroenterologia - November 9, 2017 Category: Gastroenterology Source Type: research
Psychometric property of fatigue severity scale and correlation with depression and quality of life in cirrhotics
CONCLUSION: FSS showed good psychometric performance in the evaluation of fatigue in patients with cirrhosis. Fatigue presented a strong correlation with depressive symptomatology and quality of life.RESUMO CONTEXTO: A fadiga é uma queixa comum em pacientes cirróticos e pode ser considerada um sintoma debilitante com impacto negativo na qualidade de vida. A investigação sobre a sua etiologia e tratamento tem sido dificultada pela falta de medidas relevantes e reprodutíveis da fadiga. OBJETIVO: Avaliar as proprieda des psicométricas da Escala de Gravidade da Fadiga (FSS) em pacientes cirróticos e correlacionar c...
Source: Arquivos de Gastroenterologia - November 9, 2017 Category: Gastroenterology Source Type: research
Alcohol dependence in gastroenterology outpatient on a public hospital
CONCLUSION: The present study demonstrated a high prevalence of alcohol dependence in the gastroenterology outpatient clinic, being predominantly associated with male gender and smoking. It is worth noting that approximately half of the dependents were not identified as such in the medical appointment, evidencing the importance of the diagnostic approach in the alcoholic outpatient.RESUMO CONTEXTO: O alcoolismo e a doen ça hepática alcoólica são considerados problemas de saúde de relevância mundial. OBJETIVO: Avaliar a prevalência de dependência alcoólica, os fatores de risco associados e a concordância entr...
Source: Arquivos de Gastroenterologia - November 9, 2017 Category: Gastroenterology Source Type: research
Importance of measuring levels of infliximab in patients treating inflammatory bowel disease in a brazilian cohort
CONCLUSION: In conclusion, only a third of the patients had adequate infliximab levels and 36% presented with subtherapeutic levels at the end of the induction phase. Therapy optimization occurred based in about 46% of the samples results, demonstrating the importance of having this tool to help the clinical handling of patients with inflammatory bowel diseases ongoing biologic therapy.RESUMO CONTE ÚDO: Doença de Crohn e retocolite ulcerativa são doenças inflamatórias intestinais crônicas. Nelas, ocorre aumento da produção de fator de necrose tumoral alfa (TNF- α ). Pacientes que falham no tratamento convencional...
Source: Arquivos de Gastroenterologia - November 9, 2017 Category: Gastroenterology Source Type: research
Safety profile of anti-tnf therapy in crohn’s disease management: a brazilian single-center direct retrospective comparison between infliximab and adalimumab
CONCLUSION: Adverse events were found in approximately two thirds of Crohn ’ s disease patients under anti-TNF therapy, and there were no significant differences between infliximab or adalimumab.RESUMO CONTEXTO: A utiliza ção de inibidores do fator de necrose tumoral (TNF) alfa no manejo da doença de Crohn é cada vez mais frequente. Tanto o infliximabe quanto o adalimumabe são considerados medicamentos efetivos no controle da doença. Entretanto, por serem potentes imunossupressores, podem causar efeitos adverso s importantes, principalmente infecções. OBJETIVO: O objetivo primário deste estudo foi analisar a...
Source: Arquivos de Gastroenterologia - November 9, 2017 Category: Gastroenterology Source Type: research
Adalimumab for ulcerative colitis: results of a brazilian multicenter observational study
CONCLUSION: Adalimumab was effective in the treatment of moderate-to-severe ulcerative colitis. Clinical remission was observed in approximately 40% of the patients at weeks 8 and 26, and in almost a quarter of the patients after 1 year of follow up.RESUMO CONTEXTO: O adalimumabe é um anticorpo monoclonal, inibidor do TNF alfa, que tem eficácia comprovada na indução e manutenção da remissão na retocolite ulcerativa inespecífica moderada à severa. Há escassez de dados sobre o uso do adalimumabe na retocolite ulcerativa inespecífica em pacientes latino-americanos. OBJETIVO: Analisar as taxas de remissão clíni...
Source: Arquivos de Gastroenterologia - November 9, 2017 Category: Gastroenterology Source Type: research
Adenoma detection rate evaluation and quality of colonoscopy in the center-west region of brazil
CONCLUSION: The ADR values found for the population of the studied region were compatible with internationally established goals. Continuous evaluation of the ADR may yield interventions aimed at improving quality standards for colonoscopy and promote better prevention of colorectal cancer.RESUMO CONTEXTO: O c âncer colorretal é o terceiro câncer mais incidente em homens e o segundo em mulheres em todo o mundo. Peculiaridades de sua evolução permitem medidas de prevenção secundária através da colonoscopia, com alta capacidade diagnóstica e terapêutica. Nesse contexto os indicadores de qualidade se tornam imp...
Source: Arquivos de Gastroenterologia - November 9, 2017 Category: Gastroenterology Source Type: research
Characterization of the mucin phenotype can predict gastric cancer recurrence after endoscopic mucosal resection
CONCLUSION: The mixed phenotype of early gastric adenocarcinoma is associated with a higher probability of local recurrence after endoscopic mucosal resection.RESUMO CONTEXTO: A ressec ção endoscópica da mucosa é tratamento aceito para o tratamento do câncer gástrico precoce em casos selecionados. Os critérios histopatológicos favoráveis à ressecção endoscópica curativa são adenocarcinomas intramucosos, bem diferenciados, com margens lateral e profunda livres, ausên cia de ulceração ou de embolização angiolinfática. Taxas de recorrência local próximas a 5% têm sido descritas mesmo quando se cumprem...
Source: Arquivos de Gastroenterologia - November 9, 2017 Category: Gastroenterology Source Type: research
Low prevalence of barrett’s esophagus in a risk area for esophageal cancer in south of brazil
CONCLUSION: GERD patients had a risk 30-folds greater to present columnar lined esophagus than patients without GERD symptoms. Long segments of columnar lined esophagus, had a risk eight-folds higher to have Barrett ’ s esophagus than short segments. Barrett ’ s esophagus overall prevalence was 0.7%. In GERD patients, the prevalence was 2.7%. Long Barrett ’ s esophagus represented globally 0.3% and 1.1% in GERD patients.RESUMO CONTEXTO: Es ôfago de Barrett, complicação da doença do refluxo gastroesofágico (DRGE), é lesão precursora do adenocarcinoma esofágico. O adenocarcinoma esofágico apresenta incidên...
Source: Arquivos de Gastroenterologia - November 9, 2017 Category: Gastroenterology Source Type: research
Flow mediated dilation and carotid intima media thickness in patients with chronic gastritis associated with helicobacter pylori infection
CONCLUSION: The levels of fl ow-mediated dilation, carotid intima media thickness and sICAM-1 were higher among patients with positive H. pylori infection. Patients with chronic gastritis associated with H. pylori infection are at risk of endothelial dysfunction due to fl ow-mediated dilation and carotid intima media thickness abnormalities and increased level of sICAM-1 and sVCAM-1.RESUMO CONTEXTO: A disfun ção endotelial é um dos estágios iniciais de doenças vasculares. OBJETIVO: O objetivo deste estudo foi investigar os marcadores de disfunção endotelial em pacientes com gastrite crônica associada com infe...
Source: Arquivos de Gastroenterologia - November 9, 2017 Category: Gastroenterology Source Type: research
Evaluation of human leukocyte antigen class i and ii antigens in helicobacter pylori-positive pediatric patients with active gastritis and duodenal ulcer
CONCLUSION: It was determined that HLA-B*51 plays a critical role in H. pylori infection.RESUMO CONTEXTO: Determinada como sendo a primeira bact éria cancerígena, o Helicobacter pylori (H. pylori) é um patógeno localizado no estômago em mais da metade da população mundial. Alguns estudos anteriores têm encontrado uma relação entre câncer gástrico e antígenos de histocompatibilidade de tecido dependendo das regiões. OBJETIVO: O presente estudo teve como objetivo determinar a distribuição em nosso centro do antígeno leucocitário humano (HLA) de classe I e antígenos classe II em pacientes pediátricos ...
Source: Arquivos de Gastroenterologia - November 9, 2017 Category: Gastroenterology Source Type: research
Comparative study on gastrostomy and orally nutrition of children and adolescents with tetraparesis cerebral palsy
CONCLUSION: Comparing the groups, the tetraparesis cerebral palsy patients fed orally have a greater impairment of their nutritional status, even though they have higher intakes of protein and fiber than those patients fed by gastrostomy, demonstrating a consistent argument for the use of gastrostomy.RESUMO CONTEXTO: A alimenta ção por gastrostomia é indicada para crianças com dificuldades de alimentação devido à paralisia cerebral tetraespástica, embora não haja conclusões definitivas sobre a colocação da alimentação por gastrostomia. OBJETIVO: Comparar o estado nutricional e dieta de crianças e adolesc...
Source: Arquivos de Gastroenterologia - November 9, 2017 Category: Gastroenterology Source Type: research
Primary sclerosing cholangitis in children and adolescents
CONCLUSION: Primary sclerosing cholangitis is a rare disease in childhood and adolescence and its initial diagnosis may be de layed or overlooked due to asymptomatic or unspecific clinical manifestations. The association with inflammatory bowel disease is common. Prognosis may be unfavorable as the disease progresses and hepatic transplant is the definitive treatment.RESUMO CONTEXTO: A colangite esclerosante prim ária é uma doença rara, mas sua prevalência tem sido subestimada em crianças e adolescentes, tanto pela variedade de apresentação clínica quanto pela dificuldade diagnóstica neste período. OBJETIVO: Av...
Source: Arquivos de Gastroenterologia - November 9, 2017 Category: Gastroenterology Source Type: research
Histological features of eosinophilic esophagitis in children and adolescents
CONCLUSION: In the absence of hypereosinophilia, other histological features are present in eosinophilic esophagitis and may contribute to diagnosis. Eosinophilic infiltrate is focal, therefore multiple biopsies are needed for diagnosis.RESUMO CONTEXTO: Esofagite eosinof ílica é uma doença emergente caracterizada por infiltrado eosinofílico esofágico não responsivo a inibidores de bomba de prótons. OBJETIVO: Caracterizar os achados histopatológicos de uma coorte de crianças e adolescentes com diagnóstico de esofagite eosinofílica. MÉTODOS: Estudo tran sversal conduzido em hospital terciário. Biópsias de ...
Source: Arquivos de Gastroenterologia - November 9, 2017 Category: Gastroenterology Source Type: research
