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Antimutagenic and Synergistic Cytotoxic Effect of Cisplatin and Honey Bee Venom on 4T1 Invasive Mammary Carcinoma Cell Line.
Conclusions: The MTT assay demonstrated that HBV and cisplatin could cause cell death in a dose-dependent manner. The cytotoxic effect of cisplatin also promoted by HBV. Ames test outcomes indicated that HBV could act as a significant mutagenic agent. The antimutagenic activity of HBV was increased considerably in the presence of S9 mix. Therefore, our findings have revealed that HBV can enhance the cytotoxic effect of cisplatin drug and its cancer-preventing effects. PMID: 30838042 [PubMed] (Source: Advances in Pharmacological Sciences)
Source: Advances in Pharmacological Sciences - March 8, 2019 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research

Antipathogenic Potential of a Polyherbal Wound-Care Formulation (Herboheal) against Certain Wound-Infective Gram-Negative Bacteria.
This study investigated antipathogenic efficacy of a polyherbal wound-healing formulation Herboheal against three multidrug-resistant strains of gram-negative bacterial pathogens associated with wound infections. Herboheal was evaluated for its quorum-modulatory potential against three different human-pathogenic bacteria, first in vitro through the broth dilution assay and then in vivo in the model host Caenorhabditis elegans. Herboheal at ≥0.1% v/v was able to inhibit (19-55%) in vitro production of quorum sensing-regulated pigments in all these bacteria and seemed to interfere with bacterial quorum sensing by acting as...
Source: Advances in Pharmacological Sciences - March 7, 2019 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research

In Vitro Antimicrobial Activity Screening of Ethanol Extract of Lavandula stoechas and Investigation of Its Biochemical Composition.
Authors: Canlı K, Yetgin A, Benek A, Bozyel ME, Murat Altuner E Abstract The aim of this study was to test antimicrobial activity of ethanol extract of Lavandula stoechas against 22 bacteria and 1 yeast. Also, biochemical composition of the extract was investigated. A wide range of Gram-positive, Gram-negative microorganisms, and multidrug resistant bacteria were selected to test the antimicrobial activity. As a result, the extract is observed to contain fenchone (bicyclo[2.2.1]heptan-2-one, 1,3,3-trimethyl-, (1R)-) and camphor (+)-2-bornanone) as major components and showed antimicrobial activity against...
Source: Advances in Pharmacological Sciences - February 15, 2019 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research

Nutraceuticals Inspiring the Current Therapy for Lifestyle Diseases.
Authors: Chanda S, Tiwari RK, Kumar A, Singh K Abstract Nutraceuticals are the pharmaceutically blended products that possess both nutritional as well as the medicinal value. Such a product is designed to improve the physical health, fight against day-to-day challenges such as stress, increase longevity, etc. Nowadays, emphasis is given to those herbs which are used as food and medicine due to its greater acceptance. Due to dynamic action, the popularity of nutraceuticals among people as well as healthcare providers has been increased over medicines and health supplements. This review documents herbs with ...
Source: Advances in Pharmacological Sciences - February 15, 2019 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research

Neuroprotection in Glaucoma: Old and New Promising Treatments.
Authors: Rusciano D, Pezzino S, Mutolo MG, Giannotti R, Librando A, Pescosolido N Abstract Glaucoma is a major global cause of blindness, but the molecular mechanisms responsible for the neurodegenerative damage are not clear. Undoubtedly, the high intraocular pressure (IOP) and the secondary ischemic and mechanical damage of the optic nerve have a crucial role in retinal ganglion cell (RGC) death. Several studies specifically analyzed the events that lead to nerve fiber layer thinning, showing the importance of both intra- and extracellular factors. In parallel, many neuroprotective substances have been t...
Source: Advances in Pharmacological Sciences - February 9, 2019 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research

Oleander Stem and Root Standardized Extracts Mitigate Acute Hyperglycaemia by Limiting Systemic Oxidative Stress Response in Diabetic Mice.
Authors: Dey P, Saha MR, Roy Choudhuri S, Sarkar I, Halder B, Poddar-Sarkar M, Sen A, Chaudhuri TK Abstract The extracts of different parts of Nerium oleander L. are used as antidiabetic remedy in the traditional medicinal systems of different parts of the world. Despite these uses in ethnomedicinal system, the antihyperglycemic potentials of oleander stem (NOSE) and root (NORE) extracts have not been pharmacologically evaluated. Therefore, we aimed at evaluating the antidiabetic ethnomedicinal claims of NOSE and NORE, primarily focusing on glucose homeostasis and associated metabolic implications. Alloxan...
Source: Advances in Pharmacological Sciences - February 9, 2019 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research

Total Phenolic Content and Antioxidant and Antibacterial Activities of Pereskia bleo.
Authors: Johari MA, Khong HY Abstract Different solvent extracts of Pereskia bleo leaves were evaluated for total phenolic content (TPC) and antioxidant activities based on the Folin-Ciocalteu test and DPPH scavenging activities. The antibacterial activities against four bacteria, namely, Gram-positive bacteria: Streptococcus pyogenes ATCC 19615 (SP) and Staphylococcus aureus ATCC 29737 (SA) and Gram-negative bacteria: Escherichia coli ATCC 10536 (EC) and Pseudomonas aeruginosa ATCC 9027 (PA), were also performed based on the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MB...
Source: Advances in Pharmacological Sciences - February 6, 2019 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research

Depression as a Neuroendocrine Disorder: Emerging Neuropsychopharmacological Approaches beyond Monoamines.
Authors: Chávez-Castillo M, Núñez V, Nava M, Ortega Á, Rojas M, Bermúdez V, Rojas-Quintero J Abstract Depression is currently recognized as a crucial problem in everyday clinical practice, in light of ever-increasing rates of prevalence, as well as disability, morbidity, and mortality related to this disorder. Currently available antidepressant drugs are notoriously problematic, with suboptimal remission rates and troubling side-effect profiles. Their mechanisms of action focus on the monoamine hypothesis for depression, which centers on the disruption of serotonergic, noradrenergic, and dopaminergic ...
Source: Advances in Pharmacological Sciences - February 6, 2019 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research

Evaluation of Novel 3-Hydroxyflavone Analogues as HDAC Inhibitors against Colorectal Cancer.
Authors: Biswas S, Reddy ND, Jayashree BS, Rao CM Abstract Alteration of epigenetic enzymes is associated with the pathophysiology of colon cancer with an overexpression of histone deacetylase 8 (HDAC8) enzyme in this tissue. Numerous reports suggest that targeting HDAC8 is a viable strategy for developing new anticancer drugs. Flavonols provide a rich source of molecules that are effective against cancer; however, their clinical use is limited. The present study investigated the potential of quercetin and synthetic 3-hydroxyflavone analogues to inhibit HDAC8 enzyme and evaluated their anticancer property....
Source: Advances in Pharmacological Sciences - January 30, 2019 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research

Tenofovir Disoproxil Fumarate Is Associated with a Set-Point Variation in the Calcium-Parathyroid Hormone-Vitamin D Axis: Results from a German Cohort.
Discussion: Higher levels of PTH seem to be needed to maintain normal calcium levels in PLWH on TDF-containing ART compared to non-TDF-containing ART. Optimal concentrations for 25-hydroxy vitamin D and calcium might therefore be different in people using TDF than expected from general populations but also people living with HIV with non-TDF-containing antiretroviral therapy. This might require different supplementation strategies but warrants further investigation. PMID: 30687401 [PubMed] (Source: Advances in Pharmacological Sciences)
Source: Advances in Pharmacological Sciences - January 30, 2019 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research

Therapeutic Properties of Stingless Bee Honey in Comparison with European Bee Honey.
Authors: Zulkhairi Amin FA, Sabri S, Mohammad SM, Ismail M, Chan KW, Ismail N, Norhaizan ME, Zawawi N Abstract Both honeybees (Apis spp.) and stingless bees (Trigona spp.) produce honeys with high nutritional and therapeutics value. Until recently, the information regarding potential health benefits of stingless bee honey (SBH) in medical databases is still scarce as compared to the common European bee honey (EBH) which is well known for their properties as therapeutic agents. Although there have been very few reports on SBH, empirically these products would have similar therapeutic quality as the EBH. In ...
Source: Advances in Pharmacological Sciences - January 30, 2019 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research

Phenolic Rich Fractions from Mycelium and Fruiting Body of Ganoderma lucidum Inhibit Bacterial Pathogens Mediated by Generation of Reactive Oxygen Species and Protein Leakage and Modulate Hypoxic Stress in HEK 293 Cell Line.
Authors: Mishra J, Joshi A, Rajput R, Singh K, Bansal A, Misra K Abstract Ganoderma lucidum (G. lucidum) fungus (Family Ganodermataceae) is widely used as a traditional medicine in China, Japan, and many Asian countries on account of its numerous medicinal properties such as antioxidant, anticancer, antimicrobial, energy enhancing, and immunostimulatory. This broad spectrum of therapeutic effects exhibited by G. lucidum is ascribed to its abundance in several classes of chemical constituents, namely, carbohydrates, flavonoids, minerals, phenolics, proteins, and steroids which possess substantial bioactivit...
Source: Advances in Pharmacological Sciences - January 19, 2019 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research

Niosome: A Promising Nanocarrier for Natural Drug Delivery through Blood-Brain Barrier.
Authors: Gharbavi M, Amani J, Kheiri-Manjili H, Danafar H, Sharafi A Abstract Niosomes (the nonionic surfactant vesicles), considered as novel drug delivery systems, can improve the solubility and stability of natural pharmaceutical molecules. They are established to provide targeting and controlled release of natural pharmaceutical compounds. Many factors can influence on niosome construction such as the preparation method, type and amount of surfactant, drug entrapment, temperature of lipids hydration, and the packing factor. The present review discusses about the most important features of niosomes such...
Source: Advances in Pharmacological Sciences - January 19, 2019 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research

Indigofera suffruticosa Mill. (Anil): Plant Profile, Phytochemistry, and Pharmacology Review.
Authors: Campos JKL, Araújo TFDS, Brito TGDS, da Silva APS, da Cunha RX, Martins MB, da Silva NH, Dos Santos BS, da Silva CA, Lima VLM Abstract Indigoferasuffruticosa Mill. (Fabaceae) is known as anil or anileira and also with other names, due to the production of a blue pigment, which is commonly used for yarn dyeing. It is distributed in some states of Brazil (Pernambuco, Paraíba, Mato Grosso, São Paulo, Bahia, Pará, and others) and is used in the popular medicine as a febrifuge, antispasmodic, diuretic, abortive, analgesic, purgative, or soothing agent against stomach and urinary problems, jaundice,...
Source: Advances in Pharmacological Sciences - January 13, 2019 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research

Use of Flavonoids and Cinnamates, the Main Photoprotectors with Natural Origin.
Authors: Nunes AR, Vieira ÍGP, Queiroz DB, Leal ALAB, Maia Morais S, Muniz DF, Calixto-Junior JT, Coutinho HDM Abstract Many pathological problems are initiated by ultraviolet radiation (UVR), such as skin cancer, the most commonly diagnosed cancer worldwide. The UVA (320-400 nm) and UVB (290-320 nm) wavelengths may cause effects such as photoaging, DNA damage, and a series of cellular alterations. The UVA radiation can damage the DNA, oxidize the lipids, and produce dangerous free radicals, which can cause inflammation, modify the gene expression in response to stress, and weaken the skin immune resp...
Source: Advances in Pharmacological Sciences - January 10, 2019 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research